>Tge x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xxxxxxxQAMSIPPPIS VTPVLPPPPPTISGMMPPGIDMTAPPPNTPIAPPPPQMRGPPPAVAMPPP PGMEPMNMSVSGPPGVELDDESRGKLPSLLSIKVDPPPSDMKEVKLPMAL EQALAFKTERAKQIGVEAEEM----------------------------- DNQSIPEPPPAPVISRSGLDTIYDLDDDEEEE-RVVVGAGGGGRAHQKDK RSKRKKKKKRRGRHQHKLELELQQQQKKDLETGEKESQVEIE-------- --------------xSxxxxxxxxxxxxxxxxxxxxxTNIxxxxIKKEND VETVTEAAPAIDNWKEVTPDPAISYVDFVSLDEDVAVCGEVTDENIxxxV LNNNIQTEDGASGDEEDNSLAVQERPISSAAEAMDHxQELGYIQETLGIH ELEPMYRQFARIFETFRISDPVKLDDPNDLIPKEPLKEYPPDLKKVPRLE DEYDDDDIEEDENKKQEEKTKLSKRKLKKLTRLSVAELKQLVTRPDVVEM HDVTARDPKLLVQLKAHRNTVPVPRHWCFKRK------------------ ----------------------------YLQGKRGIEKPPFDLPEFIKKT GIMEMRAALQEKEDQRTLKAKMRERARPKLGKIDIDYQKLHDAFFKWQTK PRMSIHGDLYYEGKEFETRLKEKKPGDLTDELRTALGMPTGPNAHKVPPP WLIAMQRYGPPPSYPNLKIAGLNAPIPEGCSFGYHAGGWGKPPVDENGRP LYGDVFGIQVQDLQSEPEEEEVDTAIWGELESESEEESEEEEDEDEEGGG KEDDTGLVTPVEGLITPSGITSIPAGMETPEIIELRKRKIESEMEGSVDH SLVSCAHGxxxPQHxLVSCAHGTSKPQHSLVSCAHGTSKPQHSLVSCAHG TSKPQHSLVSCTHGTSKPQHSLVSCTHGASxxxxxxxxxxxxxxxxxxSL VSCTHxxxxxxxxLVSCTHDTSKPQHSLVSCTHDTSTPxxxxxxxxxxxx xxxxxx----------------------VLPEKRMDRVGGAMMASTHIYD MTGAGAPPPAPVIRRGGLEGSGTVELALDPSELDLVDTDAMAVRYEQQIR EQQSQLQKEDLSDMLADHVARQK--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------NKRKQRQQHQDNKQAKKYKEFKF >Tpa x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------x------------------ ----------------------------YLQGKRGIEKPPFDLPEFIKKT GIMEMRAALQEKEDQRTLKAKMRERARPKLGKIDIDYQKLHDAFFKWQTK PRMSIHGDLYYEGKEFETRLKEKKPGDLTDELRTALGMPTGPNAHKVPPP WLIAMQRYGPPPSYPNLKIAGLNAPIPEGCSFGYHAGGWGKPPVDENGRP LYGDVFGIQVQDLQ--PEEEEVDTAIWGELESESEEESEEEEDEDEEGGG KEDDTGLVTPVEGLITPSGITSIPAGMETPEIIELRKRKIESEMEGSVDH SLVSCA-------------------------------------------- -------------------------------------------------- ------------------xDxxxPQHxxxxxxxx--------------xx xxxxxx----------------------VLPEKRMDRVGGAMMASTHIYD MTGAGAPPPAPVIRRGGLEGSGTVELALDPSELDLVDTDAMAVRYEQQIR EQQSQLQKEDLSDMLADHVARQK--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------NKRKQRQQHQDNKQAKKYKEFKF >Tms M------------------------------------------------- --------------------DxSxDDSNMPEQPFHERIQKQQLMIEQQRQ EELLRLQQ---------SAMAEKQQEEQERQMRQRRQEEELFRLQQEALL EKQREL-------------------------------------------- ----------------------------------------QAMSIPPPIS VTPVLPPPPPTISGMMPPGIDMTAPPPNTPIAPPPPQMRGPPPAVAMPPP PGMEPMNMSVSGPPGVELDDESRGKLPSLLSIKVDPPPSDMKEVKLPMAL EQALAFKTERAKQIGVEAEEM----------------------------- DNQSIPEPPPAPVISRSGLDTIYDLDDDEEEE-RVVVGAGGGGRAHQKDK RSKRKKKKKKRGRHQQKLELELQQQQKKDLETGEKESQVEIE-------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------YIQETLGIH ELEPMYRQFARIFETFRISDPVKLDDPNDLIPKEPLKEYPPDLKKVPRLE DEYDDDDIEEDENKKQEEKTKLSKRKLKKLTRLSVAELKQLVTRPDVVEM HDVTARDPKLLVQLKAHRNTVPVPRHWCFKRK------------------ ----------------------------YLQGKRGIEKPPFDLPEFIKKT GIMEMRAALQEKEDQRTLKAKMRERARPKLGKIDIDYQKLHDAFFKWQTK PRMSIHGDLYYEGKEFETRLKEKKPGDLTDELRTALGMPTGPNAHKVPPP WLIAMQRYGPPPSYPNLKIAGLNAPIPEGCSFGYHAGGWGKPPVDENGRP LYGDVFGIQVQDLQV----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------x >Tte M------------------------------------------------- --------------------DxSxDDSNMPEQPFHERIQKQQLMIEQQRQ EELLRLQQ---------SAMAEKQQEEQERQLRQRRQEEELFRLQQEALL EKQREL-------------------------------------------- ----------------------------------------QAMSIPPPIS VTPVLPPPPPTISGMMPPGIDMTAPPPNTPIAPPPPQMRGPPPAVAMPPP PGMEPMNMSVSGPPGVELDDESRGKLPSLLSIKVDPPPSDMKEVKLPMAL EQALAFKTERAKQIGVEAEEM----------------------------- DNQSIPEPPPAPVISRSGLDTIYDLDDDEEEE-RVVVGAGGGGRAHQKDK RSKRKKKKKRRGRHQQKLELELQQQQKKDLETGEKESQVEIE-------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------YIQETLGIH ELEPMYRQFARIFETFRISDPVKLDDPNDLIPKEPLKEYPPDLKKVPRLE DEYDDDDIEEDENKKQEEKTKLSKRKLKKLTRLSVAELKQLVTRPDVVEM HDVTARDPKLLVQLKAHRNTVPVPRHWCFKRK------------------ ----------------------------YLQGKRGIEKPPFDLPEFIKKT GIMEMRAALQEKEDQRTLKAKMRERARPKLGKIDIDYQKLHDAFFKWQTK PRMSIHGDLYYEGKEFETRLKEKKPGDLTDELRTALGMPTGPNAHKVPPP WLIAMQRYGPPPSYPNLKIAGLNAPIPEGCSFGYHAGGWGKPPVDENGRP LYGDVFGIQVQDLQSEPEEEEVDTAIWGELESESEEESEEEEDEDEEGGG KDDDTGLVTPVEGLITPSGITSIPAGMETPEIIELRKRKIESEMEGSVDH SLISCAHGx----------------------------------------- -----------------------------xxPQHSLVSCAHGTSKPQHSL VSCTHDTSIPQHSLVSCTHDTSIPQHSLVSCAHGTSTPQHSLVSCAHGTS xxxxxxxxxxxxxxxxxxxxGETPALFQVLPEKRMDRVGGAMMASTHIYD MTGAGAPPPAPVIRRGGLEGSGTVELALDPSELDLVDTDAMAVRYEQQIR EQQSQLQKEDLSDMLADHVARQK--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------NKRKQRQQHQDNKQAKKYKEFKF >Tbi -------------------------------------------------- ----------------------------MPEQPFHERIQKQQLMIEQQRQ EELLRLQQVL----DIDSAMAEKQQEEQERQLRQRRQEEELFRLQQEALL EKQREL-------------------------------------------- ----------------------------------------QAMSIPPPIS VTPVLPPPPPTISGMMPPGIDMTAPPPNTPIAPPPPQMRGPPPAVAMPPP PGMEPMNMSVSGPPGVELDDESRGKLPSLLSIKVDPPPSDMKEVKLPMAL EQALAFKTERAKQIGVEAEEM----------------------------- DNQSIPEPPPAPVISRSGLDTIYDLDDDEEEE-RVVVGAGGGGRAHQKDK RSKRKKKKKRRGRHQQKLELELQQQQKKDLETGEKESQVEIE-------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------YIQETLGIH ELEPMYRQFARIFETFRISDPVKLDDPNDLIPKEPLKEYPPDLKKVPRLE DEYDDDDIEEDENKKQEEKTKLSKRKLKKLTRLSVAELKQLVTRPDVVEM HDVTARDPKLLVQLKAHRNTVPVPRHWCFKRK------------------ ----------------------------YLQGKRGIEKPPFDLPEFIKKT GIMEMRAALQEKEDQRTLKAKMRERARPKLGKIDIDYQKLHDAFFKWQTK PRMSIHGDLYYEGKEFETRLKEKKPGDLTDELRTALGMPTGPNAHKVPPP WLIAMQRYGPPPSYPNLKIAGLNAPIPEGCSFGYHAGGWGKPPVDENGRP LYGDVFGIQVQDLQSEPEEEEVDTAIWGELESESEEESEEEEDEDEEGGG KDDDTGLVTPVEGLITPSGITSIPAGMETPEIIELRKRKIESEMEG---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------GETPALFQVLPEKRMDRVGGAMMASTHIYD MTGAGAPPPAPVIRRGGLEGSGTVELALDPSELDLVDTDAMAVRYEQQIR EQQSQLQKEDLSDMLADHVARQK--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------NKRKQRQQHQDNKQAKKYKEFKF >Tps M------------------------------------------------- --------------------DxSxDDSNMPEQPFHERIQKQQLMIEQQRQ EELLRLQQ---------SAMAEKQQEEQERQMRQRRQEEELFRLQQEALL EKQREL-------------------------------------------- -----------------------------------------AMSIPPPIS VTPVLPPPPPTISGMMPPGIDMTAPPPNTPIAPPPPQMRGPPPAVAMPPP PGMEPMNMPVSGPPGVELDDESRGKLPSLLSIKVDPPPSDMKEVKLPMAL EQALAFKTERAKQIGVEAEEM----------------------------- DNQSIPEPPPAPVISRSGLDTIYDLDDDEEEE-RVVVGAGGGGRAHQKDK RSKRKKKKKRRGRHQHKLELELQQQQKKDLETGEKESQVEIE-------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------YIQETLGIH ELEPMYRQFARIFETFRISDPVKLDDPNDLIPKEPLKEYPPDLKKVPRLE DEYDDDDIEEDENKKQEEKTKLSKRKLKKLTRLSVAELKQLVTRPDVVEM HDVTARDPKLLVQLKAHRNTVPVPRHWCFKRKVIVDVEAEEDLNSNFDFS KLRTPLFIFHYQLARPVIAIKVRQKGVQYLQGKRGIEKPPFDLPEFIKKT GIMEMRAALQEKEDQRTLKAKMRERARPKLGKIDIDYQKLHDAFFKWQTK PRMSIHGDLYYEGKEFETRLKEKKPGDLTDELRTALGMPTGPNAHKVPPP WLIAMQRYGPPPSYPNLKIAGLNAPIPEGCSFGYHAGGWGKPPVDENGRP LYGDVFGIQVQDLQAEPEEEEVDTAIWGELESESEEESEEEEDEDEEGGG KEDDTGLVTPVEGLITPSGITSIPAGMETPEIIELRKRKIESEMEG---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------GETPALFQVLPEKRMDRVGGAMMASTHIYD MTGAGAPPPAPVIRRGGLEGSGTVELALDPSELDLVDTDAMAVRYEQQIR EQQSQLQKEDLSDMLADHVARQK--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------NKRKQRQQHQDNKQAKKYKEFKF >Tdi M------------------------------------------------- --------------------DGSQDDSNMPEQPFHERIQKQQLMIEQQRQ EELLRLQQ---------SAMAEKQQEEQERQMRQRRQEEELFRLQQEALL EKQREL-------------------------------------------- ----------------------------------------QAMSIPPPIS VTPVLPPPPPTISGMMPPGIDMTAPPPNTPIAPPPPQMRGPPPAVAMPPP PGMEPMNMPVSGPPGVELDDESRGKLPSLLSIKVDPPPSDMKEVKLPMAL EQALAFKTERAKQIGVEAEEMGENSFLTILDLLTDKPKIRQDSSCATLST DNQSIPEPPPAPVISRSGLDTIYDLDDDEEEE-RVVVGVGGGGRAHQKDK RSKRKKKKKRRGRHQHKLELELQQQQKKDLETGEKESQVEIDx------- ---------Txxxxx-----------------------------xEKEND EETVTEAAPAIDNWEEVTPDPANSYVDFVSVDEDVAESGDVTDTDI---- -----------------------------------------IVKETLGIH ELEPMYRQFARIFETFRISDPVKLDDPNDLIPKEPLKEYPPDLKKVPRLE DEYDDDDIEEDENKKQEEKTKLSKRKLKKLTRLSVAELKQLVTRPDVVEM HDVTARDPKLLVQLKAHRNTVPVPRHWCFKRK------------------ ----------------------------YLQGKRGIEKPPFDLPEFIKKT GIMEMRAALQEKEDQRTLKAKMRERARPKLGKIDIDYQKLHDAFFKWQTK PRMSIHGDLYYEGKEFETRLKEKKPGDLTDELRTALGMPTGPNAHKVPPP WLIAMQRYGPPPSYPNLKIAGLNAPIPEGCSFGYHAGGWGKPPVDENGRP LYGDVFGIQVQDLQAEPEEEEVDTAIWGELESESEEESEEEEDEDEEGGG KEDDTGLVTPVEGLITPSGITSIPAGMETPEIIELRKRKIESEMEG---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------GETPALFQVLPEKRMDRVGGAMMASTHIYD MTGAGAPPPAPVIRRGGLEGSGTVELALDPSELDLVDTDAMAVRYEQQIR EQQSQLQKEDLSDMLADHVARQK--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------NKRKQRQQHQDNKQAKKYKEFKF >Tsi MxxxxxxxxFSVVAGGYCRxFDGCxPINVDGLGWACCWAAGAFPSRGSSG LALKEYLWTERRxxxxxxxxx-------MPEQPFHERIQKQQLMIEQQRQ EELLRLQQ---------SAMAEKQQEEQERQMRQRRQEEELFRLQQEALL EKQRELGRGRLYLEEKLSHLSSGKKENYLGKTTFSIPNQDPNPSPPIIGS LDYRESSTxxxxxxx------------------------xQAMSIPPPIS VTPVLPPPPPTISGMMPPGIDMTAPPPNTPIAPPPPQMRGPPPAVAMPPP PGMEPMNMPVSGPPGVELDDESRGKLPSLLSIKVDPPPSDMKEVKLPMAL EQALAFKTERAKQIGVEAEEM----------------------------- DNQSIPEPPPAPVISRSGLDTIYDLDDDExxxxRVVVGAGGGGRAHQKDK RSKRKKKKKRRGRHQHKLELELQQQQKKDLETGEKESQ------------ ----------------------------------------------KEND EETVTEAAPVIDNWEEVTPDPANSYVDFVSVDEDVAESGGVTDTDI---- -----------------------------------------IAKETLGIH ELEPMYRQFARIFETFRISDPVKLDDPNDLIPKEPLKEYPPDLKKVPRLE DEYDDDDIEEDENKKQEEKTKLSKRKLKKLTRLSVAELKQLVTRPDVVEM HDVTARDPKLLVQLKAHRNTVPVPRHWCFKRK------------------ ----------------------------YLQGKRGIEKPPFDLPEFIKKT GIMEMRAALQEKEDQRTLKAKMRERARPKLGKIDIDYQKLHDAFFKWQTK PRMSIHGDLYYEGKEFETRLKEKKPGDLTDELRTALGMPTGPNAHKVPPP WLIAMQRYGPPPSYPNLKISGLNAPIPEGCSFGYHAGGWGKPPVDENGRP LYGDVFGIQVQDLQAEPEEEEVDTAIWGELESESEEESEEEEDEDEEGGG KEDDTGLVTPVEGLITPSGITSIPAGMETPEIIELRKRKIESEMEG---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------GETPALFQVLPEKRMDRVGGAMMASTHIYD MTGAGAPPPAPVIRRGGLEGSGTVELALDPSELDLVDTDAMAVRYEQQIR EQQSQLQKEDLSDMLADHVARQK--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------NKRKQRQQHQDNKQAKKYKEFKF >Tcm x------------------------------------------------- -------------------------------------------------- ---------xxxxxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------EEEQ-RVVVGAGGGGRAHQKDK RSKRKKKKKRRGRHQHKLELELQQQQKKDLETGEKESQVEIDxSAVLLDF WEQRxxxxxT------------------------------------KEND EETVTEAAPVIDNWEEVTPDPANSYVDFVSVDEDVAESGDVTDTDI---- -----------------------------------------IAKETLGIH ELEPMYRQFARIFETFRISDPVKLDDPNDLIPKEPLKEYPPDLKKVPRLE DEYDDDDIEEDENKKQEEKTKLSKRKLKKLTRLSVAELKQLVTRPDVVEM HDVTARDPKLLVQLKAHRNTVPVPRHWCFKRK------------------ ----------------------------YLQGKRGIEKPPFDLPEFIKKT GIMEMRAALQEKEDQRTLKAKMRERARPKLGKIDIDYQKLHDAFFKWQTK PRMSIHGDLYYEGKEFETRLKEKKPGDLTDELRTALGMPTGPNAHKVPPP WLIAMQRYGPPPSYPNLKIAGLNAPIPEGCSFGYHAGGWGKPPVDENGRP LYGDVFGIQVQDLQAEPEEEEVDTAIWGELESESEEESEEEEDEDEEGGG KEDDTGLVTPVEGLITPSGITSIPAGMETPEIIELRKRKIESEMEG---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------GETPALFQVLPEKRMDRVGGAMMASTHIYD MTGAGAPPPAPVIRRGGLEGSGTVELALDPSELDLVDTDAMAVRYEQQIR EQQSQLQKEDLSDMLADHVARQK--------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------NKRKQRQQHQDNKQAKKYKEFKF >Tce M------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------xxx------------- -------------------------------------------------- ---------------------------------------x---------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------YIQETLGIH ELEPMYRQFARIFETFRISDPVKLDDPNDLIPKEPLKEYPPDLKKVPRLE DEYDDDDIEEDENKKQEEKTKLSKRKLKKLTRLSVAELKQLVTRPDVVEM HDVTARDPKLLVQLKAHRNTVPVPRHWCFKRK------------------ ----------------------------YLQGKRGIEKPPFDLPEFIKKT GIMEMRAALQEKEDQRTLKAKMRERARPKLGKIDIDYQKLHDAFFKWQTK PRMSIHGDLYYEGKEFETRLKEKKPGDLTDELRTALGMPTGPNAHKVPPP WLIAMQRYGPPPSYPNLKIAGLNAPIPEGCSFGYHAGGWGKPPVDENGRP LYGDVFGIQVQDLQAEPEDEEVDTAIWGELESESEEESEEEEDEDEEGGG KEDDTGLVTPVEGLITPSGITSIPAGMETPEIIELRKRKIESEMEGSVDY SLVSCAHA------------------------------------------ -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxGETPALFQVLPEKRMDRVGGAMMASTHIYD MTGAGAPPPAPVIRRGGLEGSGTVELALDPSELDLVDTDAMAVRYEQQIR EQQSQLQKEDLSDMLADHVARQKxxxxxxxxxxFxxxxxxxxxxxxxSLL QNKEDDLSPIEIEPRVPPGTMSRFYFPPKPLKRKGLSHPTLxxxPTFSRV FEIPSTPRNRDSDVVTLHKVYGNTLPAKATRSTNSRTAWYLTCSLERMLY WLPMNVQLSVVGQVIVDDERHLLYINTSCPHVCGDENAATQHINTFxxxx xxxxxxxQLRSSLMVIHPLKDEEGKSSPSAIGSESSTSTHVTSRLCDQNW WLEKKQSNFVLTLSPSAIILYLRLRLTLPGLYPTSHGDSRCWDSVLPPTA THVAGTLSYLPRRLTLPGLYPTxHRDSHCRDSILPPTATPVLPVLLPSTS PPFPFACPCHRxxHEKVYTRSSSKSHTSLNTTLPSFKxxxDKRTWTSRRN IFSTYQRMELGxxxxxxxxxxxxNLRSQ------------------