>Tge ------M------xFDLDQKVRAVVYNWMLEPSQLFSKSTQPKTSHVTQ- ---VLPFDIG---DESTIxLxxxxxxxxxExxxxxxxxxASKTSPVTESK TxxxxxxxxxxxxxxxxxxxxxxxxxxxSIQGHLQIPCLEICAGHSCHLx xxxxxxxxxxxxxxxxxxxxxx---------------------------- ------------------GQLTRLPKFIIINCLPISVGTRLKRQTHRIWF Axxx---------------------------------------------- -------------------VEDRDSEERLHNTWPPPITPYYEPEEDQSNQ IYQPHGSQASR----xQxxxLSxIxxxQHxxxxxNIRLKRGPRFISRRQC RAAPTEKKVICASSLRSIGCTRPTRRTVLLRASGDAEHxxxxxRRxxxxx xLxxxxxxxLTSx-----------SEYSPRRVTGSLARPRGHPRITTGLY HTSQWGTARIPYRGAVVKVPVVGESRKxxxxxxxxxxxxxxGVDGRNHER NTLxxxxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------xxx----------- ----------------------xxxxDIKATSTDNQQQFHxxxxxxxxxx xxxxxxxxxxxxGYAVQDASVEDQVCVRCPVDRTVVASRGTDFVFMPHSK LKKCKHRPRVPGAKWEYLYGPRPGSIITEGSHVVAGRALYNHKQLQQCQx xxxVLGMNTFSSCLQYYRYRVLGMNTFSSCLQYYRxxVLGMNTFSSCLQY YRYIVLGMNTFSSxxxxxxYIVLVRKCPPLMLPKYVDAHCSRGNVWGSEC ELLCHQGYQLHGHNVTVCGDQLLWSNSLPQCSVMTDCPLPMSPSHGRLSC HTPDGSVSSNLLPEGSVCRYMCDEGYSVPESESHLLIxxxxxxxxxxxxx xxxxxxxxxxxxxxx----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------- >Tms ------Mx------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxVEDRDSEERLHNPWPPPSNHYIEPEEDQSNQ IYQPHGPQATRVLHQP---------------------------------- -------------------------------------------------- -----------SSLHACTHLPDYxSEYSPRRVTGSLARPRGHPRITTGLY HTSQWGTARIPYRGAVVKVPVVGESHx----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------THK GTVTTTIxxxxQAxxxxxxGIP----DIRATSADNQQQFHSNxxxxxxxx xxxxxxxxxxxxGYAVQDASVEDQVCVRCPVDRTVVASRGTDFVFMPHSK LKKCKHRPKVPGAKWEYLYGPRPGSIISEGSHVVAGRALYNHKQLQQCQ- ----------------YR-------------------------------- -------------------YTVLVRKCPPLMLPKYVDAHCSRGNVWGSEC ELVCQQGYQLRGHNLTACGDQLMWTNPLPQCSVMTDCPLPMSPSHGRLSC HTPDGSVSSDLLPEGSVCRYMCDEGYSVPESESHLLV------------- -------------TMCTAAEWNSTADPSCQxTQQYYNYNHNTQPQVxxxx xxxxxxxVRVRHRAHxxxxTHR---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------- >Tsi ------MxLCFTMTFDLDHKVRAVVYNWMLEPSQFFSKSTQPKTSHVTQx xxxx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxxxx---------------------------------------- ------------------xVEDRDSGERLHNPWPPPSNHYYEPEEDQSNQ IYQPHGPQASR--------------------------------------- -------------------------------------------------- ------------------------SEYSPRRVTGSLARPRGHPRITTGLY HTSQWGTARIPYRGAVVKVPVVGESHx----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------THK GTVTTTIxxxxQASTRYSxGIPVQIVGIKVTSADNQQQFHSNxxxxxxxx xxxxxxxxxxxxGYAVQDASVEDQVCVRCPVDRTVVASRGTDFVFMPHSK LKKCKHRPRVPGAKWEYLYGPRPGSIITEGSHVVAGRALYNHKQLQQCQ- ----------------YR-------------------------------- -------------------YTVLVRKCPPLMLPKYVDAHCSRGNVWGSEC ELVCHQGYQLRGHNVTACGDQLMWTNPLPQCSVTTDCPLPMSPSHGRLSC HTPDGSVSSDLLPEGSVCRYMCDEGYSVPESESHLLV------------- -------------TLCTAAEWNSTADPSCQxTQQY--FTDNTQPQVxxxx xxxxxxxVRVRxRAHxxxxTHR---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------xxxxxxxxxxxx xxxxxxxxxxK--------------------------------------x xxxxxxxxxxxxxxxxxxx------------------------------- ----------- >Tps -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------x---------------------- -------------------------------------------------- -------------------------xxx--xxxxxxxxxxxx-------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxTHK GTVTTTIxxxxQASTRYSxGIP---------------------------- ------------GYAVQDASVEDQVCVRCPVDRTVVASRGTDFVFMPHSK LKKCKHRPRVPGAKWEYLYGPRPGSIITEGSHVVAGRALYNHKQLQQCQ- ----------------YR-------------------------------- -------------------YTVLVRKCPPLMLPKYVDAHCSRGNVWGSEC ELVCHQGYQLRGHNVTACGDQLMWTNPLPQCSVTTDCPLPMSPSHGRLSC HTPDGSVSSDLLPEGSVCRYMCDEGYSVPESESHLLV------------- -------------TLCTAAEWNSTADPSCQ---------xNTQPQVxxxx xxxxxxxVRVRxRAHxxxxTHR---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------xxxxxxxxxxxx xxxxxxxxxxK-----------------------------------xxxx ------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxKEGKAx >Tdi xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------EEDQSNQ IYQPHGSQASR--------------------------------------- -------------------------------------------------- ------------------------SEYSPRRVTGSLARPRGHPRITTGLY HTSQWGTARIPYRGAVIKVPVVGQSHx----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------THK GTVTTTIxxxxQASTRYSxxIP---------------------------- ------------GYAVQDASVEDQVCVRCPVDRTVVASRGTDFVFMPHSK LKKCKHRPRVPGAKWEYLYGPRPGSIITEGSHVVAGRALYNHKQLQQCQ- ----------------YR-------------------------------- -------------------YTVLVRKCPPLMLPKYVDAHCSRGNVWGSEC ELVCHQGYQLRGHNVTACGDQLMWTNPLPQCSVTTDCPLPMSPSHGRLSC HTPDGSVSSDLLPEGSVCRYMCDEGYSVPESESHLLV------------- -------------TLCTAAEWNSTADPSCQ---------xNTQPQVxxxx xxxxxxxVRVRxRAHxxxxTHR---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------xxxxxxxxxxxx xxxxxxxxxxKxxxxxxxxxx-----------------------xx---- ----------------------------xxxxxxxxxxxxxxxxxxxxxx xxxxxKEGKAx >Tcm ------Mxx----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------VEDRDSGERLHNPWPPPSNHYYEPEEDQSNQ IYQPHGPQASR--------------------------------------- -------------------------------------------------- ------------------------SEYSPRRVTGSLARPRGHPRITTGLY HTSQWGTARIPYRGAVVKVPVVGESHK----------------------- -------------------------------------------------- -----------------------------------------xxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxSKRxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-xxK GTVTTTILNRxxxxTRYSxxxP---------------------------- ------------GYAVQDASVEDQVCVRCPVDRTVVASRGTDFVFMPHSK LKKCKHRPRVPGAKWEYLYGPRPGSIITEGSHVVAGRALYNHKQLQQCQ- ----------------YR-------------------------------- -------------------YTVLVRKCPPLMLPKYVDAHCSRGNVWGSEC ELVCHQGYQLRGHNVTACGDQLMWTNPLPQCSVTTDCPLPMSPSHGRLSC HTPDGSVSSDLLPEGSVCRYMCDEGYSVPESESHLLV------------- -------------TLCTAAEWNSTADPSCQxTQQY--FTDNTQPQVxxxx xxxxxxxVRVRHRAHxxxxTHR---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------- >Tbi ------xxLCVTITFDLDQKARAVVSNWMLEPSQLFSKSTQPKTSHVTQ- ---VPPFDVGSGRD------------------------------------ -------------------------------------------------- -------------------AxSCKGxxx----GLQDLIQIKNIAHNYLFV LEMVLIITIVLDDFPDYLGQLAQLPKFIIIDYLPISVGTRLKRQTHRIWF AGVR---------------------------------------------- -------------------VEGRDGEERLHNPWPPPITHYYEPEEDQSNQ IYQPHGSQASR--------------------------------------- -------------------------------------------------- ------------------------SEYSPRRVTGSLARPRGHPRTTTGLY HTSQWGTARIPYRGAVVKVPVVGESRKREPCSFHLTAPACxGVDGRNYER NTLSCHSDTIQVRLSGAGxxxTTRSFRRDCTSATEASYKGPxxxxHGGRS QILFGFSAYENAVKYMLQAHLTCxxSCxxxxxxxxxxxxxxx-------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xTVTTTIxxxxxxxxxxxxxxP---------------------------- ------------GYAVQDASVEDQVCVRCPVDRTVVASRGTDFVFMPHSK LKKCKHRPRVPGAKWEYLYGPRPGSIITEGSHVVAGRALYNHKQLQQCQY RYTVLGMNTFSSCLQYYR-------------------------------- -------------------YTVLVRKCPPLMLPKYVDAHCSRGNVWGSEC ELLCQQGYQLHGHNVTVCGDQLMWTNPLPQCSVMMDCPLPMSPSHGRLSC HTPDGSVSSDLLPEGSMCRYMCDEGYSVPESESHLLV------------- -------------TLCTAAEWNSTADPSCQ-------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xxxxxx------------------ -------------------------------------------------- -------------------------------xxxxxxxxxxxxxxxxxxx xxxxxxxxxxx---------xxxxxxxxxxxxxxxxxxxxxxxxx----- -------------------------------------------------- ----------- >Tte ------M------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxxxxxxxLIQIKNxxxxxxxx xxxxxxIxxxxxxxxxxxGQLAQLPKFIIIDYLPISVGTRLKRQTHRIWF Axxx---------------------------------------------- -------------------VEGRDSEERLHNPWPPPTTHYYEPEEDQSNQ IYQPHGSQASR--------------------------------------- -------------------------------------------------- ------------------------SEYSPRRVTGSLARPRGHPRTTTGLY HTSQWGTARIPYRGAVVKVPVVGESRKxxxxxxxxxxxxxxGVDGRNYER NTLSCHSDTIQVRLSGxxxxCTTRSFRRDCTSATEASYKGPxxxxHGGRS QILFGFSAYENxxxxMxxxxxxxxxxxxxxxxxxxxxxxxxx-------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxK GTVTTTILSRxxxxTRYSxxxx---------------------------- ------------GYAVQDASVEDQVCVRCPVDRTVVASRGTDFVFMPHSK LKKCKHRPRVPGAKWEYLYGPRPGSIITEGSHVVAGRALYNHKQLQQCQx xxxVLGMNTFSSCLQYYR-------------------------------- -------------------YTVLVRKCPPLMLPKYVDAHCSRGNVWGSEC ELLCQQGYQLHGHNVTVCGDQLMWTNPLPQCSVMMDCPLPMSPSHGRLSC HTPDGSVSSDLLPEGSVCRYMCDEGYSVPESESHLLV------------- -------------TLCTAAEWNSTADPSCQ---------xNTQPQVxxxx xxxxxHxxxxxxxxxxxxxAHSxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxNRxxx----------------------------------------- ----------------------xxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------- >Tpa ------x------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------x-------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxTxK GTVTTTIxxxxxxxTRYSxxxPVQIVDIKATSTDNQQQFHPNxxxxxxxx xxxxxxxxxxxxGYAVQDASVEDQVCVRCPVDRTVVASRGTDFVFMPHSK LKKCKHRPRVPGAKWEYLYGPRPGSIITEGSHVVAGRALYNHKQLQQCQx xxxVLGMNTFRSCLQYYRYTVLGMNTFRSxxxxx---------------- ------------------xYTVLVRKCPPLMLPKYVDAHCSRGNVWGSEC ELLCHQGYQLHGHNVTVCGDQLMWSNSLPQCSVMTDCPLPMSPSHGRLSC HTPDGSVSSNLLPEGSVCRYMCDEGYSVPE-------------------- ---------------------------------------xxxxxxxxxxx xxxxxHxVRVRxRAHxxxxAHSxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxRxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxE xxxxxxxxxxxxxxxxxxxxxxxxx------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------x----- -------------------------------------------------- ----------- >Tce ------x------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------RPKVPGAKWEYLYGPRPGSIISEGSHVVAGRALYNHKQLQQCQ- ----------------YR-------------------------------- -------------------YTVLVRKCPPLMLPKYVDAHCSRGNVWGSEC ELVCQQGYQLRGHNVTACGDQLMWTNPLPQCSVMTDCPLPMSPSHGRLSC HTPDGSVSSDLLPEGSVCRYMCDEGYSIPESESHLLV------------- -------------TMCTAAEWNSTADPSCQxTQQYxxxxxNTQPQVxxxx xxxxxxxxxxxxxxxxxxxTHSxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxRxxx----------------------------------------- -------------------------------xTxxSxxxxxxxxxxxxxx xxxxxxxxxxRRxxxxxxxxxxxxxKDKxxxxxxxxxxxxxxxxxxxxxx xxxxxxxYxxSxxxIWxLAHPDKPLTSNxVRRxxxxx------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxx-xxxxxx xxxxxxxxxxx