>Tge ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MINCVNKSL TKCKERVDKLSTECIDRNEAECKERVGTSTSPLLNFSPNLNSVGRSR-GFR--GRKPSSA GHDSFNNSRGRGKIRGPRSRSPSDAPSLPNRSLIRGHGGGRGPRRRRSSSSSPSPPTLTR IHGSGKRPKKKINRSSVDLGGSNRNTRLRSSSVSPSPPPILSRGHSVNMGKNKLSPSPTS SRCDSPMPNLHMEFCPHRITRQMTANLSSSPCRPVKEDSSDEDFN--------PRKVS-- --------------------------------------RNKKFSDKPRKKINNEHEDKRK SSSHKREGSESPTKEQTLSSKRTRRK---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------L >Tte -----------------------------------------MFMI--------------- --------------EMIPEFG--------------------------------------- ------------------------------------------------LVKEGFGNQINL CWDQGLNPGPSARKSDTLPPGHQVTKKSIYLYGLADHVSNMTQSQESRVSSTQDSLSLRP TEDSISRETQEQGVSALVNKLSSCSGAYENEKSSYSSSGDEKKMQALLPWIKSFNSLCQS VVGCRSLKRLEKLLQIFWKNMSDPVKKSLKMTNRTAK-LKKYMSEVLLFFHMSYLDLQEV LDNNTYLERMSDLVSMYIDMEIRASKEETCPLYGNGDQEIVVGRNRKVLNLVRPSTAPMY TMLYV-RYLLAYKLWKKVVGNAEEKKRINKLAALKLSAPTELTEKVVLWPSVLPKVPKSK KN-----------------IGIDSSGNLFDGIWSLLCNADSNTSDGTKTISPLGVKSERH ISSTQKYKPKEKAPKKLKMKLINENKKPSSSNKVKKKTKCKKKNAIKPSDTMSVLSVKKG IKLPNNTIRKKKKNKFVKERLSVNFLTTALGTLSSSLSKPSMRDFISTSTSHSFSSSEEQ SSSFGSISASLGSLPSPMERFTSAPLENLSAPVPIHSSPSSSDSLSSLPPPLEDLQIMSH SGISPLPPLDSELQRPARLENNQLRKSSDSPSPSVPCPDTVAPSVASLTPPHPSAPLSPP TEDPQNKLELMDTEEGVQRTQEQETSKAAESNIPDVPAQSVVSKDIQNISELPSPNVIGV QLNCVSENVIHTTEALLAPGVSEEMTLCVPELPQVEIKAEPEVENINQVTQAKPQALCVQ KQNDLQQDSKIDLHNEISNLNITHSNDETTHDADQGFVPMQDGRLNIKVDVDSMENGDLN HETEISIANVKSSDTQYFDAPSNEVISEQTEICLQEVVVSQVEEEI-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------NFISANSKDVPIEISVANKTVTNLSNSIQMTNSITANSIKEIPL IDVSSNEDSAGTLDSSDS------------------------------------------ ------------------------------------------------------------ ---------------------------------------------YDSDVEILEDIINNG INNNSGTSEGEEVISNVSNQTPREDHGVFGLGPGELVMEVIGMSGPVSVIYSGSYAPRED LGQSSVDSESQPVHFDETEHFVDTTNLLDDTLRDRERDDYTY---GRNSQDCLYRDVMLT GNRLNESGDTNYESFDLESYPLFQEDFMEGDEDDDLENTLVEDDLDSPIREGGRKYKSKN FALDSEKENSDGSPTSQVDVDN-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------RTVAENEALKSQDEELLKKIEESLSESARTKQEGLKDNFDEAF HNATKEPGYKSMSLNTIQSKDANMNCVDTKQFSGKTETSKRMFKTPAELKQISMPEDFVS STVNLKSE------PVLIPLDSKIDRTFNLGKRDCSGNPVNPPCEKLETKQGLDLTINKE IKSKKRSRRRKSDGETGHVKSSKRHLKRESVIQTSETVDEFIRGRPRGFRGVGSNRYRGG RRKSPSLDEYQ---------------ERVEKSPTQTFEKSYDRFEERVEKSLINCVNKSH TKCKERVDKLSTECIDRNEAECKERVGTSTSPLLNFSPNLNSVGRSR-GFRGSGRKPSSA GHDSFNNSRGRGKIRGPRSRSPSDAPSLPNRSLIRGHGGGRGPRRRRSSSSSPSPPTLTR IHGSGKRPKKKINRSSVDLGGSNRNTRLRSSSVSPSPPPILSRGHSVNMGKNKLSPSPTS SRCDSPMPNLHMEFCPHRITRQMTANLSSSPCRPVKEDSSDEDFN--------PRKVS-- --------------------------------------RNKKFSDKPRKKINSEHEDKRK SSSHKREGSESARIAVRAPGYIFKRPGFNSQCFWNFSVKQWVTLSLMRTTGYVQDIARHD TIIPQGSGTLVRDTWQRRVKAATTIPTQPSAPQTAKHDHYESATTLDETATTPSSLEQNS QYSVELLSLVGTELLVKREEWLEGLGAVLLGVLAVLEGAAQGAALFCFFATSRVSRIPSS SSMMSDDDSDRELFFMGQELDHWFLDLPVVIELARPVVPRLTRGQELDHWFLDLPVVMI >Tms MQPLKQLDSMSNTGALKSSGLISTQVMDLTRGSPLGQITVGLFLMRNKKWVQLAERSAHT VMPRLMPELSFQACQVSPHTGHAGTIIPYYVNRLQLAVPSAQGLNLAQEAQRNSSFFSHA GLIWPLPPQIRQEAFRYQQLPAVEYFTLAPLPSFSDPLRRNSPTQSHLTPGNPFLNTHSP LPGSPLSLPSDPLTTVSYPLAHLLDWEN-FNWDFVFIVSNMTQSQESRVSSTQDSLSLRP TEDSIS------SVSALVNKLSSCSGIYENEKSSYSSSGDEKKMQALLPWIKNFNSLCQS VVGCRSLKRLEKLLQIFWKNMSDPVKKSLKMTNRTAK-LKKYMSEVLLFFHMSYLDLQET -----------------------TLR--------------------KVLNFVRPSTAPMY TMLYV-RYLLAYKLWKKVVGNAEEKKRINKLAAVKLSAPTELTEKVVLWPSVLPKVPKSK KNVTLFLMQAKFDLKKSCQIGIDSSGNLFDGIWSLLCNVDSNTSDGTKTISPMGVKSERH ISSTQKYKPKEKAPKKLKMKLINENKKPSSSNKVKKKTKCKKKNAIKPSDTLSVLSVKKG IKLPNNTTRKKKKNKFVKERLSVNFLTTALGTLSSSLSKPSMRDFISTSTSHSFSSSEEQ SSSFGSISASLGSLPSPMERFTSAPLENVSAPVPIHSSPSSSDSLSSLPPPLEDLQIMSP SGISPLPPLDSELQRPAHLENNDLRKSFDSPSPSVPCPDTVAPSVASLTPSHPSAPLSPL TEDLQNKLELMDTEEGVQRMQEQETSKVAESNIPDVPEQSVVNKDIQNVSELTPPNISGV KLNCVSEIVIQTTEALLALGVSEEMTLCVPELPQVEIKAEPEVENINKVIHAKPQALCVQ KQNNVQQDSKIDLHNEISNLNITHSNDETTHNADQGSVPMQDGRLNIKVDVDSMENRDLS HETEISIANVKSSDTQYFDAPSNEVISEQTEICLQEEVVSQVEEEISTHSVEDGVSAIQI NDTEHLYSSVSNHSFYHSEEH-STNLPEKTFTKSVINSNRTIDAEVALDKEVINRETAQI DVSHVTPPMAIIPNSERNILFSTEDQCYAKKQSDLLTSNISKNTSDCIDRSNSESCPSNS ATVGISLSELERNKLNKPQQQKINQTNITKKSIIHFDEQGSTSTNSLKGINANNSENNPI TSTIETSVHKIMDSSLDFISANSKDVPIEVSVANKTVTNFSNSIKITNSITPNSIKEIPL IDVSSNEDSAGTLDSSDSVSDLATKIERTNVLDDSFVTNGNADSSSVILASNSALRCDFK SVISSQTTTVRLDPCDRLRAPTSSNNMINKTSHVDNEAVPITVNSKHLNQEKSTGLVSLT EDDGHSSDEPQIIGEERYCSADSSIKNESRSRSAFSDSQRGYYVEYDSDVEILEDIINNG INNNSGTSEGEEVISNVSNQTPRDDHGVFGLGPGELVMEVIGMSGPVSVIYSGSYAPRED LGQSSVDSESQPVHFDETEHFVDTTNLLDDTPRDRERDDYTY---GRNSQDCLYRDVMLT GNRLNESGDTNYESFDFESYPLFQEDFMEGDEDDDIENTLVEDDLDSPIREGGRKYRSKN FALDSEKENSDGSPTSQGDIENVHTNNLTEENRRLFLAQQSERDNISVKTKPTDKSFPTV RFSDVNRYYPATLPSVQVDDVRNETKHDPPIKLSRTAKSLAAANEESAYLGRVTTVQLKQ LPNQADPLLNL--GQSIISKENLDAKLLGNESPAIPKR--------------------GS PAYNGQFHTQFRNTNIQRTVAENEALKSQDEELLKKIEESLSESARTKQEGIKDNFD--- ---------------------------DTKQFSGKTETSKRMFKTPAELKQISMPEDFVS STVNLKSEPCLMPIPVLIPLDSKIDRTFNLGKRDCSGNPVNPPCEKLETKQGLDLTINKE IKS---------------------------------------RGRPKGVRGVGPNRDRGG RRKSPSLDENQERVENSPSKIYDGCKERVEKSPTQTFEKSYDRFKERVEKSLINCVNKSH TKCKERADKLSTECIDINEAECKERVGTSTSPLLNFSPNLNSVGRNRGGFRGSGRKPSSA GHDSFNNSRGRRKIRGPRSRSPSNAPSLPNRSLIRGHGGGRGPRRRRSSSSSPSPPTLTR IHGSGKRPKKKMNRSSLDLGGGNRNTRLRSSSVSPSPPPILSRGHSVNMGKKKLSPSPTS SRCDSPMPNLHMEFCPHRITRQMTANLSSSPCRPVKEDSSDEGV----------VETALE YYMFWHIYG----AIIRTKSKKKYAIGYGAS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------N >Tsi ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MY TMLYV-RYLLVYKLWKKVVGNTEEKKRINKLAAVKLSAPTELTEKVVLWPSVLPKVPKSK KNVTLFLMQAKFDLKKSCQIGIDSSGNLFDGIWSLLCNVDANTSDGTKTISPMGVKSDRH ISSTQKYKPKEKAPKKLKMKMINENKKPSSSNKVKKKTKCKKKNAIKPSDTMSVLSVKKG IKLPNNTIRKKKKNKFVKERLSVNFLTTALGTLSSSLSKPSMRDFISTSTSHSFSSSEEQ SSSFGSISASLGSLPSPMERFTSAPLENVSAPAPIHSSPSSSDSLSSLPAPLEDLQMMSP SGISPLPPLDSELQRPAHLENNDLRKSSDSPSPSIQCPDTVAPSVASLTPSHPSAPLSPL TEDLQNKLELMDTEEGVQRMQEQETSKVAESNIPGVSGQSVVNKDIQNISELTPPNISGV KLNCVSETVIQTTEALLALGVSEEMTSCVSELPRVEIKAEPEVENINQVIHAKPQALCVQ KQNNVQQDSKIDLHNEISNLNITHSTDETTHNADQGSIPMQDGRLIIKVDVDSMENRDLS HETEISIANVKSSDTQYFDAPSNEVISEQTEICLQEEVVSQVEEEISTCSVEDGVSAIKI NDTEHLYSSVSNHSFYTSEEL-STNLPEKTFTKFVINSNRTIDTEVGLDKEVVNRDTAQI DFGHVTPPMAIISNSERNILFSTEDQCSAKKQSDLLTSNISKNISDCIDRSISESCPPNS ATVGISLSELERNKLNKPQQQKINQTNITKKS-IHFDEQGSTSTNSLKGINANNSENNPI TSTIETSVHEIMNSSLDLISANSVDVPIEVSVANKTVPNLSNSIKITNSITANSIKEIPL IDVSSNEDSAGTLDSSDSVSDLATKIERTNVLDDSCVTNGNADSSSVILASNSALRYDFK SVISSQTTTVKLDPCDRLRAPTSSNNMINKTSHVDNEAVPITVNSKLLNQEKSTGLVSLT EDDGHSSDEPQIIGEERYCSADSSIENKSRSRSAFSDSQRGYYVEYDSDVEILEDIIHNG INNNSGTSEGEEVISNVSNQTPRDDHSVFGLGPGELVMEVIGMSGPVSVIYSGNYAPRED LGQSSVDSESQPVHFDETEHFVDTTNLLDDTPRDRERDDYTYVRNDRNSQDCLYRDVMLT GNSLNESGDTNYESFDFESYPLFQ-DFMEGDEEDELENTLVEDDLDSPIREGGRKYRSKN FALDSENENSDGSPTS-------------------------------------------- ------------------------------------------------------------ ---QADPLLNLGQGQSIISKENLDAKLLGNESPAIPKR--------------------GS SAYNGQFHTQFRNTNIQRTVAENEALKSQDEELLKKIEESLSESARTKQE---------- ---------------------------DTKQFSGKTETSKRLFKTPAELKQISMPEDFVS STVNLKSEPCLMPIPVLIPLDSKIDRTFNLGKRDCSGNPVNPPCEKLETKQGLDLTINKE IKSKKRSRRRKSDG----------------------------RGRPKGVRGVGPNRDRGV RRKSPSLDENQEGVEKSPSKIYDECKERVEKSPTQTFEKSYDRFKERVEKSLINCVNKDH TKCIERADKLSTECIDINEAECKERVGTSTSPLLNFSPNLNSVGRNRGGLRGSGRKPSSA GHDSFNNSRGRRKIRGPRSRSPSDAPSLPNRSLIRLYGSGRGHRRRRSSSSSPSPPTLTR IHGSGKRPKKKMNRSSLDLGGGNRNTRLRSSSVSPSPPPILSRGHSAKMGKKKSSPSPTS SRCDSPMPSLHMEFCPHRITRQMTANLSSSPFRPVKEDSSDEDFN--------PRKVS-- --------------------------------------RSKKFSDKPRKKTNSEHEDKRK SSSHKREGSESARLAVRTPGYRSKSPGFNSQCFWNFSVKQWVTLGLMRTTG--------- ----------------------------------------ES------------------ ------------------------------------------------------------ ---------------------------------------------------------FE >Tcm ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------MTQSQESRVSSTQDSLSLRP TEDSIS------SVSALVNKLSSCSGKYENEKLSYSSSGDEKKMQALLPWIKSFNSLCQS VVGCRSLKRLEKLLQIFWKNMSDPVKKSLKMTNRTAK-LKKYMSEVLLFFHMSYLDLQEV LDNDTYLERMSDLVSMYIDMEIRASK--------------------KVLNFVRPSTAPMY TMLYV-RYLLVYKLWKKVVGNTEEKKRINKLAAVKLSAPTELTEKVVLWPSVLPKVPKSK KNVTLFLMQAKFDLKKSCQIGIDSSGNLFDGIWSLLCNVDANTSDGTKTISPMGVKSERH ISSTQKYKPKEKAPKKLKMKMINENKKPSSSNKVKKKTKCKKKNAIKPSDTMSVLSVKKG IKLPNNTIRKKKKNKFVKERLSVNFLTTALGTLSSSLSKPSMRDFISTSTSHSFSSSEEQ SSSFGSISASLGSLPSPMERFTSAPLENVSAPAPIHSSPSSSDSLSSLPAPLEDLQMMSP SGISPLPPLDSELQRPAHLENNDLRKSSDSPSPSIQCPDTVAPSVASLTPSHPSAPLSPL TEDLQNKLELMDTEEGVQRMQEQETSKVAESNIPGVSGQSVVNKDIQNISELTPPNISGV KLNCVSETVIQTTEALLALGVSEEMTSCVSELPRVEIKAEPEVENINQVIHAKPQALCVQ KQNNVQQDSKIDLHNEISNLNITHSTDETTHNADQGSIPMQDGRLNIKVDVDSMENRDLS HETEISIANVKSSDTQYFDAPSNEVISEQTEICLQEEVVSQVEEEISTCSVEDGVSAIKF NDTEHLYSSVSNHSFYTSEEL-STNLPEKTFTKSVINSNRTIDTEVGLDKEVVNRDTAQI DFGHVTPPMAIISNSERNILFSTEDQCSAKKQSDLLTSNISKNISDCIDRSISESCPPNS ATVGISLSELERNKLNKPQQQKINQTNITKKS-IHFDEQGSTSTNSLKGINANNSENNPI TSTIETSVHEIMNSSLDFISANSVDVPIEVSGANKTVTNLSNSIKITNSITANSIKEIPL IDVSSNEDSAGTLDSSDSVSDLATKIERTNVLDDSCVTNGNADSSSVILASNSALRYDFK SVISSQTTTVKLDPCDRLRAPTSSNNMINKTSHVDNEAVPITVNSKLLNQEKSTGLVSLT EDDGHSSDEPQIIGEERYCSADSSIENKSRSRSAFSDSQRGYYVEYDSDVEILEDIIHNG INNNSGTSEGEEVISNVSNQTPRDDHSVFGLGPGELVMEVIGMSGPVSVIYSGNYAPRED LGQSSVDSESQPVHFDETEHFVDTTNLLDDTPRDRERDDYTYVRNDRNSQDCLYRDVMLT SNSLNESGDTNYESFDFESYPLFQ-DFMEGDEEDELENTLVEDDLDSPIREGGRKYRSKN FALDSENENSDGSPTT-------------------------------------------- ------------------------------------------------YLGRVTTVQLKQ LPNQADPLLNLGQGQSIISKENLDAKLLGNESPAIPKR---------------------- ------------------------------------------------------------ ---------------------------DTKQFSGKTETSKRLFKTPAELKQISMPEDFVS STVNLKSEPCLMPIPVLIPLDSKIDRTFNLGKRDCSGNPVNPPCEKLETKQGLDLTINKE IKSKKRSRRRKSDG----------------------------RGRPKGVRGVGPNRDRGA RRKSPSLDENQEGVEKSPSKIYDECKERVEKSPTQTFEKSYDRFKERVEKSLINCVNKDH TKCIERADKLSTECIDINEAECKERVGTSTSPLLNFSPNLNSVGRNRGGLRGSGRKPSSA GHDSFNNSRGRRKIRGPRSRSPSDAPSLPNRSLIRLYGSGRGHRRRRSSSSSPSPPTLTR IHGSGKRPKKKMNRSSLDLGGGNRNTRLRSSSVSPSPPPILSRGHSAKMGKKKSSPSPTS SRCDSPMPSLHMEFCPHRITRQMTANLSSSPFRPVKEDSSDEDFN--------PRKVS-- --------------------------------------RSKKFSDKPRKKTNSEHEDKRK SSSHKREGSESARLAVRTPGYRSKSPGFNSQCFWNFSVKQWVTLGLMRTTG--------- ----------------------------------------ES------------------ ------------------------------------------------------------ ---------------------------------------------------------FE >Tdi ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------MTQSQESRVSSSQDSLSLRP TEDSIS------SVSALVNKLSSCSGKYENEKLSYSSSGDEKKMQALLPWIKSFNSLCQS VVGCRSLKRLEKLLQIFWKNMSDPVKKSLKMTNRTAK-LKKYMSEVLLFFHMSYLDLQEV LDNDTYLERMSDLVSMYIDMEIRASK--------------------KVLNFVRPSTAPMY TMLYV-RYLLVYKLWKKVVGNAEEKKRINKLAAVKLSAPTELTEKVVLWPSVLPKVPKSK KNVTLFLMQAKFDLKKSCQIGIDSSGNLFDGIWSLLCNVDSNTSDGTKTISPMGVKSERH ISSTQKYKPKEKAPKKLKMKMINENKKPSSSNKVKKKTKCKKKNAIKPSDTMSVLSVKKG IKLPNNTIRKKKKNKFVKERLSVNFLTTALGTLSSSLSKPSMRDFISTSTSHSFSSSEEQ SSSFGSISASLGSLPSPMERFTSAPLENVSAPVPIHSSPSSSDSLSSLPAPLEDLQMMSP SGISPLPPLDSELQRPAHLENNDSRKSSDSPSPSVQCPDTVAPSVASLTPSHPSAPLSPL TENLQNKLELMDTEEGVQRMQEQETSKVAESNIPGVPGQSVVNKDIQNISELTLPNISGV KLNCVSETVIQTTEALLALGVSEEMTSCVSELPRVEIKAEPEAENINQVIHAKPQALCVQ KQNNVQQDSKIDLHNEISNLNITHSHDETTHNADQGSVPMQDGRLNIKVDVDSMENRDLS HETEISIANVKSSDTQYFDAPSNEVISEQTEICLQEEVVSQVEEEISTCTVEDGVSAIKI NDTEHLYSSVSNHSFYTSEEL-STNLPEKTFTKSVINSNRTIDTEVGLDKEVINRDTAQI DFGHVTPPMTIISNSERNILFSTEDQCSAKKQSDLLTSNISKNISDCIDRSISESCPPNS ATVGISLSELERNKLNKPQPQKINQTNITKKS-IHFDEQGSTSTNSLKGINANNSENNPI TSTIETSVPEIMNSSLDFISANSMDVPIEVSVANKTVTNLSNSIKITNSITANSIKEIPL IDVSSNEDSAGTLDSSDSVSDLATKIERTNVLDDSFVTNGNADSSSVILASNSALRYDFK SVISSQTTTVKLDPCDRLRAPTSS-----KTSHVDNEAVPITVNSKLLNQEKSTGLVSLT EDDGHSSDEPQIIGEERYCSADSSLENKSRSRSAFSDSQRGYYVEYDSDVEILEDIIHNG INNNSGTSEGEEVISNVSNQTPRDDHSVFGLGPGELVMEVIGMSGPVSVIYPGNYAPRED LGQSSVDSESQPVHFDETEHFVDTTNLLDDTPRDRERDDYTYVRNGRNSQDCLYRDVMLT GNSLNESGDTNYESFDFESYPLFQ-DFMEGD-EDELENTLVEDDLDSPIREGGRKYRSKN FALDSENENSDGSPTSQVDIENVQTNNLTEENR--------------------------- -----------------------------------------------PYLGRVTTVQLKQ LPNQADPLLNL--GQSIISKENLDAKLLGNESPAIPKR--------------------GS PAYNGQFHTQFRNTNIQRTVAENEALKSQDEELLKKIEESLSESARTKQEGIKDNFD--- ---------------------------NTKQFSGKTETSKRMFKTPAELKQISMPEDFVS STVNLKSEPCLMPIPVLIPLDSKIDRTFNLGKRDCSGNPVNPPCEKLETKQGLDLTINKE IKSKKRSRRRKSDG----------------------------RGRPKGVRGVGPNRDRGA RRKSPSLDENQEGVEKSPSKIYDECKERVEKSPTQTFEKSYDRFKERVEKSLINCVNKNH TKCIERADKLSTECIGINEAECKERVGTSTSPLLNFSPNLNSVGRNRGGLRGSGRKPSSA GHDSFNNSRGRRKIRGPRSRSPSDAPSLPNRSLIRLYGSGRGHRRRRSSSSSPSPPTLTR IHGSGKRPKKKMNRSSLDLGGGNRNTRLRSSSVSPSPPPILSRGHSAKMGKKKLSPSPTS SRCDSPMPSLHMEFCPHRITRQMTANLSSSPFRPVKEDSSDEDFN--------PRKVS-- --------------------------------------RSKKFSDKPRKKSNSEHEDKRK LSSHKREGSESARLAVRTPGYRSKSPGFNSQCFWNFSVKQWVTLGLMRTTG--------- ----------------------------------------ES------------------ ------------------------------------------------------------ ---------------------------------------------------------FE >Tps ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------MTQSQESRVSSSQDSLSLRP TEDSIS------SVSALVNKLSSCSGKYENEKLSYSSSGDEKKMQALLPWIKSFNSLCQS VVGCRSLKRLEKLLQIFWKNMSDPVKKSLKMTNHNSE-V-----------HILDAILKAR LINKNNEKICNPILG-------------------------------KVLNFVRPSTAPMY TMLYV-RYLLVYKLWKKVVGNAEEKKRINKLAAVKLSAPTELTEKVVLWPSVLPKVPKSK KNVTLFLMQAKFDLKKSCQIGIDSSGNLFDGIWSLLCNVDSNTSDGTKTISPMGVKSERH ISSTQKYKPKEKAPKKLKMKMINENKKPSSSNKVKKKTKCKKKNAIKPSDTMSVLSVKKG IKLPNNTIRKKKKNKFVKERLSVNFLTTALGTLSSSLSKPSMRDFISTSTSHSFSSSEEQ SSSFGSISASLGSLPSPMERFTSAPLENVSAPVPIHSSPSSSDSLSSLPAPLEDLQMMSP SGISPLPPLDSELQRPAHLENNDSRKSSDSPSLSVQCPDTVAPSVASLTPSHPSAPLSPL TENLQNKLELMDTEEGVQRMQEQETSKVAESNIPGVPGQSVVNKDIQNISELTLPNISGV KLNCVSETVIQTTEALLALGVSEEMTSCVSELPRVEIKAEPEAENINQVIHAKPQALCVQ KQNNVQQDSKIDLHNEISNLNITHSHDETTHNADQGSVPMQDGRLNIKVDVDSMENRDLS HETEISIANVKSSDTQYFDAPSNEVISEQTEICLQEEVVSQVEEEISTCTVEDGVSAIKI NDTEHLYSSVSNHSFYTSEEL-STNLPEKTFTKSVINSNRTIDTEVGLDKEVINRDTAQI DFGHVTPPMAIISNSERNILFSTEDQCSAKKQSDLLTSNISKNISDCIDRSISESCPPNS ATVGISLSELERNKLNKPQPQKINQTNITKKS-IHFDEQGSTSTNSLKGINANNSENNPI TSTIETSVPEIMNSSLDFISANSMDVPIEVSVANKTVTNLSNSIKITNSITANSIKEIPL IDVSSNEDSAGTLDSSDSVSDLATKIERTNVLDDSFVTNGNADSSSVILASNSALRYDFK SVISSQTTTVKLDPCDRLRAPTSS-----KTSHVDNEAVPITVNSKLLNQEKSTGLVSLT EDDGHSSDEPQIIGEERYCSADSSIENKSRSRSAFSDSQRGYYVEYDSDVEILEDIIHNG INNNSGTSEGEEVISNVSNQTPRDDHSVFGLGPGELVMEVIGMSGPVSVIYPGNYAPRED LGQSSVDSESQPVHFDETEHFVDTTNLLDDTPRDRERDDYTYVRNGRNSQDCLYRDVMLT GNSLNESGDTNYESFDFESYPLFQ-DFMEGD-EDELENTLVEDDLDSPIREGGRKYRSKN FALDSENENSDGSPTS-------------------------------------------- ------------------------------------------------------------ ---QADPLLNL--GQSIISKENLDAKLLGNESPAIPKR--------------------GS PAYNGQFHTQFRNTNIQRTVAENEALKSQDEELLKKIEESLSESARTKQE---------- ---------------------------DTKQFSGKTETSKRMFKTPAELKQISMPEDFVS STVNLKSEPCLMPIPVLIPLDSKIDRTFNLGKRDCSGNPVNPPCEKLETKQGLDLTINKE IKSKKRSRRRKSDG----------------------------RGRPKGVRGVGPNRDRGA RRKSPSLDENQEGVEKSPSKIYDECKERVEKSPTQTFEKSYDRFKERVEKSLINCVNKNH TKCIERADKLSTECIDINEAECKERVGTSTSPLLNFSPNLNSVGRNRGGLRGSGRKPSSA GHDSFNNSRGRRKIRGPRSRSPSDAPSLPNRSLIRLYGSGRGHRRRRSSSSSPSPPTLTR IHGSGKRPKKKMNRSSLDLGGGNRNTRLRSSSVSPSPPPILSRGHSAKMGKKKLSPSPTS SRCDSPMPSLHMEFCPHRITRQMTANLSSSPFRPVKEDSSDEGM----------RKVEFL DEVYTHLYG----G------------------------RGKPFRKK-------------- -----------------------------------------------HPTG--------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------S >Tce ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------MTQSQESRVSSTQDSLSLRP TEDSIS------SVSALVNKLSSCSGIYENEKSSYSSSGDEKKMQALLPWIKNFNSLCQS VVGCRMGDKDNDNFDLL------PLDTWAIFSCIQARGMVAYNSEV----HILDAILKAR LINKNNEKICNPILG-------------------------------KVLNFVRPSTAPMY TMLYV-RYLLAYKLWKKVVGNAEEKKRINKLAAVKLSAPTELTEKVVLWPSVLPKVPKSK KNVTLFLMQAKFDLKKSCQIGIDSSGNLFDGIWSLLCNVDSNTSDGNKTISPMGVKSERH ISSTQKYKPKEKAPKKLKMKLINENKKPSSSNKVKKKTKCKKKNAIKPSDTLSVLSVKKG IKLPNNTTRKKKKNKFVKERLSVNFLTTALGTLSSSLSKPSMRDFISTSTSHSFSSSEEQ SSSFGSISASLGSLPSPMERFTSAPLENVSAPVPIHSSPSSSDSLSSLPPPLEDLQIMSP SGISPLPPLDSALQRPAHLENNDLRKSFDSPSPSVPCPDTVAPSVASLTPSHPSAPLSPL TEDLQNKLELMDTEEGVQRMQEQETSKVAESNIPDVPEQSVVNKDIQNVSELTPPNISGV KLNCVSETVIQTTEALLALGVSEEMTLCVPELPQVEIKAEPEVENINKVIHAKPQALCVQ KQNNVQQDSKIDLHNEISNLNITHSNDETTHNADQGSVSMQDGRLNIKVDVDSMENRDLS HETEISIANVKSSDTQYFDAPSNEVISEQTEICLQEEVVSQVEEEISTHSVEDGVSAIQI NDTEHLYSSVSNHSFYHSEEH-STNLPEKTFTKSVINSNRTIDAEVALDKEVINRETAQI DFSHVTPPMAIIPNSERNILFSTEDQCYAKKQSDLLTSNISKNTSDCIDRSNSESCPSNS ATVGISLSDLERNKLNKPQQQKINQTNITKKSIIHFDEQGSTSTNSLKGINANNSENNPI TSTIETSVHKIMDSSLDFISANSKDVPIEVSVANKTVTNLSNSIKITNSITPNSIKEIPL IDVSSNEDSAGTLDSSDSVSDLATKIERTNVLDDSFVTNGNADSSSVILASNSALRCDFK SVISSQTTTVRLDPCDRLRAPTSSNNMINKTSHVDNEAVPITVNSKHLNQEKSTGLVSLT EDDGHSSDEPQIIGEERYCSADSSIKNESRSRSAFSDSQRGYYVEYDSDVEILEDIINNG INNNSGTSEGEEVISNVSNQTPRDDHGVFGLGPGELVMEVIGMSGPVSVIYSGSYAPRED LGQSSVDSESQPVHFDETEHFVDTTNLLDDTPRDRERDDYTY---GRNSQDCLYRDVMLT GNRLNESGDTNYESFDFESYPLFQEDFMEGDEDDDLENTLVEDDLDSPIREGGRKYRSKN FALDSEKENSDGSPTSQGDIENVHTNNLTEENRRLFLAQQ-------------------- -----------------------------------------------TYLGRVTTVQLKQ LPNQADPLLNL--GQSIISKENLDAKLLGNESPAIPKR--------------------GS PAYNGQFHTQFRNTNIQRTVAENEALKSQDEELLKKIEESLSESARTKQEGIKDNFD--- ---------------------------DTKQFSGKTETSKRMFKTPAELKQISMPEDFVS STVNLKSEPCLMPIPVLIPLDSKIDRTFNLGKRDCSGNPVNPPCEKLETKQGLDLTINKE IKSKKRSRRRKSDG----------------------------RGRPKGVRGVGPNRDRGG RRKSPSLDENQERVENSPSKIYDGCKERVEKSPTQTFEKSYDRFKERVEKSLINCVNKSH TKCKERADKLSTECIDINEAECKERVATSTSPLLNFSPNLNSVGRNRGGFRGSGRKPSSA GHDSFNNSRGRRKIRGPRSRSPSNAPSLPNRSLIRGHGGGRGPRRRRSSSSSPSPPTLTR IHGSGKRPKKKMNRSSLDLGGGNRNTRLRSSSVSPSPPPILSRGHSANMGKKKLSPSPTS SRCDSPMPNLHMEFCPHRITRQMTANLSSSPCRPVKEDSSDEGV----------VETALE YYMFWHIYG----AIIRTKSKKKYAIGYGANFNPRKVSRSKKLSDKPRKKINSEHEDKRK SSSHKREGSESARLAVRTPGYRSKSPGFNSQCFWNFSVKQWVTLFLMRTTG--------- ----------------------------------------ES------------------ ------------------------------------------------------------ ---------------------------------------------------------LE >Tbi ------------------------------------------------------------ ---------------METHLGKT------------------------------------- --------------------------------TLSAPNRDQTPFSLSLAVKEGFGNQINL CWDQGLNPGPSARKSDTLPPGHQVTKKSIYLYGLADHVSNMTQSQESRVSSTQDSLSLRP TEDSIS------SVSALVNKLSSCSGAYENEKSSYSSSGDEKKMQALLPWIKSFNSLCQS VVGCRSLKRLEKLLQIFWKNMSDPVKKSLKMTNRTAK-LKKYMSEVLLFFHMSYLDLQEV LDNNTYLERMSDLVSMYIDMEIRASK--------------------KVLNLVRPSTAPMY TMLYV-RYLLAYKLWKKVVGNAEEKKRINKLAALKLSAPTELTEKVVLWPSVLPKVPKSK KNVTLFLMQAKFDLKKSCQIGIDSSGNLFDGIWSLLCNADSNTSDGTKTISPLGVKSERH ISSTQKYKPKEKAPKKLKMKLINENKKPSSSNKVKKKTKCKKKNAIKPSDTMSVLSVKKG IKLPNNTIRKKKKNKFVKERLSVNFLTTALGTLSSSLSKPSMRDFISTSTSHSFSSSEEQ SSSFGSISASLGSLPSPMERFTSAPLENLSAPVPIHSSPSSSDSLSSLPPPLEDLQIMSH SGISPLPPLDSELQRPARLENNQLRKSSDSPSPSVPCPDTVAPSVASLTPPHPSAPLSPP TEDPQNKLELMDTEEGVQRTQEQETSKAAESNIPDVPAQSVVSKDIQNISELLSPNVIGV QLNCVSENVIHTTEALLAPGVSEEMTLCVPELPQVEIKAEPEVENINQVTQAKPQALCVQ KQNDLQQDSKIDLHNEISNLNITHSNDETTHDADQGFVPMQDGRLNIKVDVDSMENGDLN HETEISIANVKSSDTQYFDAPSNEVISEQTEICLQEVVVSQVEEEISTCSVEDGVSAIQI NDTENLYSTVSNHSFYHSEELIPTNLSEKTITKSVTNSNRTIDAEVGLDKEVINRETAQI DFGNVTPPMAIITNPEKNISFSTEDQCYAKKQSDLLTCNISKNISDCIDRSNSESCPQNS VTVGVSLSELERNKLNKPQQQMINQTNVIKKSIIHFDEQGSASTNSPKSIISNNSENNPI TSTIETSLHEIMDSSLDVISANSKDVPIEISVANKTVTNLSNSIQMTNSITANSIKEIPL IDVSSNEDSAGTLDSSDSVSDLATKIERTNVLDDSFVTNGNADSSSVILTSNSALRCDFK SVISSQTTTVRLDPCDRLRAPTSSNNMINKTSHVANEAVPITVNSKLLNQEKSTGLVSLT EDDGHSSDEPQIIGEERYCSADSSIKNESRNRSAFSNSQRDYYVEYDSDVEILEDIINNG INNNSGTSEGEEVISNVSNQTPREDHGVFGLGPGELVMEVIGMSGPVSVIYSGSYAPRED LGQSSVDSESQPVHFDETEHFVDTTNLLDDTLRDRERDDYTY---GRNSQDCLYRDVMLT GNRLNESGDTNYESFDLESYPLFQEDFMEGDEDDDLENTLVEDDLDSPIREGGRKYKSKN FALDSEKENSDGSPTSQVDVDNVHTTSLTEENRRLFLAQQ-------------------- -----------------------------------------------TYLGRVTTVQLKQ LPNQADPLLNL--GQSIISKENLDAKLLGNEPPAIPKR--------------------GS PAYNGQFPTQFRNTNIQRTVAENEALKSQDEELLKKIEESLSESARTKQEGLKDNFD--- ---------------------------DTKQFSGKTETSKRMFKTPAELKQISMPEDFVS STVNLKSE------PVLIPLDSKIDRTFNLGKRDCSGNPVNPPCEKLETKQGLDLTINKE IKSKKRSRRRKSDG----------------------------RGRPRGFRGVGSNRYRGG RRKSPSLDEYQ---------------ERVEKSPTQTFEKSYDRFEERVEKSLINCVNKSH TKCKERVDKLSTECIDRNEAECKERVGTSTSPLLNFSPNLNSVGRSR-GFRGSGRKPSSA GHDSFNNSRGRGKIRGPRSRSPSDAPSLPNRSLIRGHGGGRGPRRRRSSSSSPSPPTLTR IHGSGKRPKKKINRSSVDLGGSNRNTRLRSSSVSPSPPPILSRGHSVNMGKNKLSPSPTS SRCDSPMPNLHMEFCPHRITRQMTANLSSSPCRPVKEDSSDEATTNSCSLEVTIKHTLLH NSLFTSIPSTLLLGIVPINCARQFEMGFA------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------E >Tpa ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------MRLLQ VTDVIF-----------INNLCHPQG-----------------------WRKAF------ -----------------------PV----------------------------------- --------------------------------------------------FLRRKSSPHH LEVYPHRWEVSRHRWKGLL----------------------------------------- ----LHLLK----------------------IFLHLCQ---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------FHSSPSSSDSLSSLPPPLEDLQLMSH SGISPLPPLDSELQRPAPLENNQLRKSSDSPSPSVPCPDTVAPSVASLTPSLQSAPLSPP TEDPQNKLELMDTEEGVQRTQEQETSKAVESNIPDVPAQSVGSKDIQNISELPSPNVTGV QLNCVSENVINTTEALLALGVSEEMTLCVPELPQVEIKAEPEVENINQVTQAKPQALCVQ KQNDLQQDSKIDLHNEISNLNITHSNDETTHNADQGFVPMQDGRLNIKVDVDSIENEELN HETEISIANVKSSDTQYFDAPSNEVISEQTEICLQEVVVSQVEEEISTCSVEDGVSAIKI NDTENLYSTVSNHSFYHSEELIPTNLPEKTFTKSVTNSNRTIDAEVGLDREVINRENAQI DFGNVTPPMAIIPNPEKNIPFSTEDQCYAKKQSDLLACNISKNITECIDRSNSESCPPNS VTVGISLSELERNKLNKPQQQMINQTNVIKKSIIHFDEQGSASTNSPKSINSNNSVNNPI TSTIETSLHEIMDSSLDLISANSKDVPIEISVANKTVTNLSNSIQMTNSITANSIKEIPL IDVSSNEDSAGTLDSSDSVSDLATKIERTNVLDDSFVTNGNADSSSVILTSNSALRCDFK SVISSQTTTVRLDPCDRLRAPTSSNNMINKTSHVDNEAVPITVNSKLLNQEKSTGLVSLT EDDGHSSDEPQIIGEERYCSADSSIKNESRNRSAFSNSQRDYYVEYDSDVEILEDIINNG INNNSGTSEGEEVISNVSNQTPRDDHGVFGLGPGELVMEVIGMSGPVSVIYSGGYAPRED LGQSSVDSESQPVHFDETEHFVDTTNLLDDTPRDRERDDYTY---GRNSQDCLYRDVMLT GNRLNESGDTNYESFDFESYPLFQEDFMEGDEDDDLENTLVEDDLDSPIREGGRKYKSKN FALDSEKENSDGSPTSQVDVDNVHTNSLTEENR--------------------------- -----------------------------------------------PYLGRVTTVQLKQ LPNQADPLLNL--GQSIISKENLDAKLLGNEPPAIPKRGITYNPYIRCTCSVCYAMLQGS PAYNGQFHTQFRNTNIQRTVAENEALKSQDEELLKKIEESLSESARTKQEGLKDNFD--- ---------------------------DMKQFSGKTETSKRMFKTPAELKQISMPEDFVS STVNLKSEQCPIPIPVLIPLDSKIDRTFNLGKRDCSGNLVTPPCEKLETKQGLDLTINKE IKSKKRSRRRKSDG----------------------------RGRPRGFRGVGSHRYRGS RRKSPSLDEYQ---------------EGVEKSPTQTFDKSYDRFEERVEKSMINCVNKSQ TKCKERVDKLSTECIDRNEAECKERVGTSTSPLLNFSPNLNSVGRSR-GFR--GRKPSSA GHDSFNNSRGRGKIRGPRSRSPSDAPSLPNRSLIRGHGGGRGPRRRRSSSSSPSPPTLTR IHGSGKRPKKKINRSSV------------------------------------------- ----------------------------------VK------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------V