>Tge x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------A------------------------------------- ---------------------------------DHLTPRVISHINKKSFF PVSARQREDDGYQIENCYRLLERSGQNEILNKDTPSEEGGELGFHNFYGN REDIHKLINAEVADHRTKGREGLVSHMELWKGNTGEMLREASRKKALNDW LVSLAPSVSHR-------------------------------VWVEMCVA YSEQLTVQGLFHKAASYLLVCNKVEEAIQLLVNNKCFREAMCIAKSRLDS DDPTINNVFIEWGNKLGNSDGNFVQAAECYLASGELDLAAKMFAKKKTAE YLKLSALVSRKCGNFAQALSQAKQCFQECMHQENWDLADDIVLEYKELK- -----------------------PYHLLLIMHREVLSLLASDQDKFGSWL LGNRPLHTSLLDRVASCWQTNDKQTVYCELHSGLDHSQPPQQTLNQMWLC VSKELSLSLSSEEKGLWHLVNAVAICYRYQLLHPSQPVLLQLCSWLAPAG PFTEGSVFLLSSQNTSKLSFVHSLRAFLGAAIAFWLDIVVKLSEDLEQQS LLGVNGESKNDNERITEPDEECDASRRDLVNDKDPTIEAQEINNSRTVIE SAEGMTDTQKVVEGVKEEVNDLLEKIIKVCGHKPNKEIKCHENDDTKPKT NKEFIESKIDSSSSNIDASKITCVRLANETTCAYEDSASLNWAAVCTVLE ELLVDVLDKHSTQYFQNEIKIKKLELLVAGAVASARKSSALGESTKQIED KNVAESKNESKIDDAINHNILIEVTEAQTENGAVEGKKKDQVLFDTSSDT NMIKNAILNEDNQTIADAQFGTSDAELRGNTYLNEGEPTPTAANLVQGHK SRDPTANSGLLKLQELKKCKEKFEMEKVAxxxNxxxxxxxxxxxxxxxxx xxxxxxxxx------------------------------------ >Tbi x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---Kx----xDE-------------------------------DISSFLK QIQHCVNPTSSKFKITTELAWKPDFTLLALGLDDGTVHVLSAPHLTLLHT LFTIKKMIQCLAWHPESTATDTGLSPYRDWLAVSSNERTITVFDTSQLSK GGPDINNKTIKRCITLTGHLNRVVSMAWSPHVSGQLVSVSFDDTAQVWDV PNQSLVANYPSHESNPLCCVWSPLDPDMIITGSADCTLRVWKISSQTxKF PKEK--------------------------------KTGKKPTSSLPVNS QASTxxFAxNDRA------------------------------------- ---------------------------------DHLTPRVISHINKKSFF PVSSRQREDDGYQIENCYRLLERSGQNEILNKDTPSEEGGELGFHNFYGN REDIHKLINAEVADHRTKGREGLVSHMELWKGNTGEMLREASRKKDLNDW LVSLAPSVSHR-------------------------------VWVEMCVA YSEQLTVQGLFHKAASYLLVCNKVEEAIQLLVNNKCFREAMCIAKSRLDS DDPTINNVFNEWGNKLGNSDGNFVQAAECYLASGELDLAAKMFAKKKTAE YLKLSALVSRKCGNFAQALSQAKQCFQECMHQENWDLADDIVSEYKELK- -----------------------PYHLVLIMHREVLSLLAADQGKFGSWL LGNRPLHTSLLDRVASCWQTDDKQTVYCELHSGLDHSQPPQQTLNQMWLC VSKELSLSLSSEEKGLWHLVNAVAICYRYQLLHPSQPVLLQLCSWLAPAG PFTEGSVFLLSSQDTSKLSFVHSLRAFLGAAIAFWLDIVVKLSEDLEQQS PLGVNGESKNDNERITEPHEECDTSRRDLVNDKDPTIEAQEINNSITVIE SAEGMTDTQKVVEGVKEEVNDLLEKIIKVCGHKPNKEIKCNENDDTKPKT NKEFIESKIDSSSSNIDASKITCVRLANETTCAYEDSASLNWAAVCTVLE ELLVDVLDKHSTQYFQNEIKIKKLELLVAGAVASARKSSALGESTKQIED KNVAEGKNESKIDDAINHNILIEVTETQTENGAVEGKKKDQVLFDTSSDT NMIKNVILNEDNQTIADAQFGTSDAELRGNSYLNEGEPTPTAANLVQGHK SRDPIANSGLLKLQELKKCKEKFEMEKVA--------------------- -------VPNPFFIYCKVQTMCQNVIMKKEPQLGQRLLDLLKNSM >Tte x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------LLQMWLC VSKELSLSLSSEEKGLWHLVNAVAICYRYQLLHPSQPVLLQLCSWLAPAG PFTEGSVFLLSSQDTSKLSFVHSLRAFLGAAIAFWLDIVVKLSEDLEQQS PLGVNGESKNDNERITEPDEECDASRRDLVNDKDPTIEAQEINNSITVIE SAEGMTDTQKVVEGVKEEVNDLLEKIIKVCGHKPNKEIKCNENDDTKPKT NKEFIESKIDSSSSNIDASKITCVRLANETTCAYEDSASLNWAAVCTVLE ELLVDVLDKHSTQYFQNEIKIKKLELLVAGAVASARKSSALGESTKQIED --VAEGKNESKIDDGINHNILIEVTEAQTENGALEGKKKDPVLFDTSSDT NMIKNAILNEDNQTIADAQFGTSDAELRGNSYLNEGEPTPTAANLVQGHK SRDPIANSGLLKLQELKKCKEKFEMEKVA--------------------- -------VPNPFFIYCKVQTICQNVIMKKEPQLGQRLLDLLKNSM >Tpa x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxDHLTPRVISHINKKSFF PVSARQREDDGYQIENCYRLLERSGQNEILNKDTPSEEGGELGFHNFYGN REDIHKLINAEVADHRTKGREGFVSHMELWKGNTGEMLREASRKKALNDW LVSLAPSVSHRYWRRVAFLRMSDHDSSYRLAGERCESCSASIVWVEMCVA YSEQLTVQGLFHKAASYLLVCNKVEEAIQLLVNNKCFREAMCIAKSRLDS DDPTINNVFIEWGNKLGNSDGNFVQAAECYLASGELDLAAKMFAKKKTAE YLKLSALVSRKCGNFAQALSQAKQCFQECMHQENWDLADDIVLEYKELK- -----------------------PYHLVLIMHREVLSLLASDQGKFGSWL LGNRPLHTSLLDRVASCWQTDDKQTVYCELHSGLDHSQPPQQTLNQMWLC VSKELSLSLSSEEKGLWHLVNAVAICYRYQLLHPSQPVLLQLCSWLAPAG PFTEGSVFLLSSQDTSKLSFVHSLRAFLGAAIAFWLDIVVKLSEDLEQQS PLGVNGESKNDDERITEPDEECDASRRDLVNDKDPTIEAQEINNSRTVIE SAEGMTDTQKVVEGVKEEVNDLLEKIIKVCGHKPNKEIKCNENDDTKPKT NKEFIESKIDSSSSNTDASKITCVRLANETTCAYEDSASLNWAAVCTVLE ELLVDVLDKHSTQYFQNEIKIKKLELLVAGAVASARKSSALGESTKQIED KNVAEGKNESKIDDAINHNILIEVTEAQTENGAVEGKKKDQVLFDTSSDT NMIKNAILNEDNQTIADAQFDPSDAELRGNSYLNEEEPTPTVANLVQGHK SRDPTANSGLLKLQELKKCKEKFEMEKVA--------------------- -------VPNPFFIYCKVQTICQNVIMKKEPQLGQRLLDLLKNSM >Tms xxxxxxxxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------ISSFLK EIQQSVNPTTSKFKFTTELAWKPDFTLLALGLDDGTVHVFSAPHLTLLHT LFTIKKMIQCLAWHPESTATDTGLSPYRHWLAVSSNERTITVVDTSKLTK GESDINNKTIKSCFTLTGHLNRVVSMAWSPHVSGQLVSVSFDDTAQVWDV PNQSLVANFPSHESNLLCCVWSPLDPDMIITGSADCTLRVWKISSQTNKF PKEK---------------------------------------------- ------------T------------------------------------- ---------------------------------DHLTPRVISHINKKSFF PVSSRRREDDSYQIENCYRLLERGGQDEIINKDTPSEEGGELGFHHFYGN REDIHTLINAEVAEHRTKGREMLISHMELWKGNTGEMLREASRKKALNDW LVSLAPSISHR-------------------------------VWVEMCVA YSEQLTVQGLFHKAASYLLVCNKVEEAIQLLVNNKCFREAMCIAKSRLDS DDPTINNVFIEWGNKLGNSDGNFVQAAECYLASGELDLAAKMFAKKKTAE YLKLSALVSRKCGNYALALSQAKQCFQECMHQENWDLADDIVSEYMELK- -----------------------PYHLVVIVHREVLNLLAADQGKFGSWL LGNRLIDTSLLERVASRWQTDDKQTVYSELHSGLDHNQSAQQTLNQMWLC VSKELSLSFSSEEKGLWHLVNAVAICYRYQLLHPSQPVLLQLCSWLAPAG PFTKGSVFLLSSQDTSNMSFVHSLRAFLGAAIAFWLDIVVKLSEDLEQQS PLGVNGKSKNDNEQITEPNEECDAHTRDLINNKNITIKSQEINKSITVIE SAEGMTDTQKVVEGVKEEVNDILEKIINVCGNKPNKEIKCNEKDDTKTKT NKEFIESKIDISSSNIDASKITCVGVSDETTCVFEHSGSLNWAAVCTVLE ELLVDVLDKHSTQYFQNEIEIKKLELLVAGAVASTRKSSALGESPKHIED NNVAEDRNENKIDDAINHNMRIEVTEAHTENGVVEGKKKDQVLFDTISDT NIIKNSILNEDNQTIADAQFGTGYSVLRGNSYLNEGEPTPTAAHLVQGHN SRDTFTNSGLLKLKELKNCKEKFEMEKVA--------------------- -------VPNPFFIYCKVQTICQNVIMKKEPQLGQRLLDLLKNSL >Tce x--------xEITIPPSPNWYLGDILSCNNDGVFVYGSRNDLIVCRHKSR VxLADGPQVQMIRVAHKEKVTVVRLSKTNGGKYPHSVATVGDDSIVKLWD LETLSLLQAHNFHEGSKVVDMDWSIADPNLVVSVDENNNIICWNLSTNST QRLTLFKLRAMCLACCPHKADTIAVGSRTGLVFVIKIKDGGQVLYRMRGH DSEVVSIAWCPVSYNIFKQSKTEQLLSRDMLLASAGKDRDVYIWRAGTDG QCQTKFNLPVTLVATVESSGHYRSGGSNAPSVGMFRMCLRWPEPSTLLTS TAWGELLKWRLTETGEDAAHKG------SQKPVKDKLSKNYQLLHNIHLR GLFSIACTPAIVQDETANFWTSSTDSVPSEDNLNSEEKEVLIDGMNxSKE QQLVWTTAQDRLIVACDLKTGKLVAKIPTFGGFVYAVAVSPVDSD----- -------------------------------------------------- ------------------------------------SISTTVAQITLSTL ALFLQTSxxTKETALSxxxPLTLSxxxxxEDPKNIPELVLYSCAVGEIFQ HNxKK----PDE-------------------------------DISSFLK EIQQSVNPTTSKFKFTTELAWKPDFTLLALGLDDGYRHGF---------- --------------------------YRHWLAVSSNERTITVVDTSKLTK GESDINNKTIKSCITLTGHLNRVVSMAWSPHVSGQLVSVSFDDTAQVWDV PNQSLVANFPSHESNLLCCVWSPLDPDMIITGSADCTLRVWKISSQTNKF PKEK--------------------------------NTGKKAASSLPVNS QASTEVFAINDRA------------------------------------- ---------------------------------DHLTPRVISHINKKSFF PVSSRRREDDSYQIENCYRLLERGGQDEIINKDTPSEEGGELGFHHFYGN REDIHKLINAEVAEHRTKGREMLISHMELWKGNTGEMLREASRKKALNDW LVSLAPSISHR-------------------------------VWVEMCVA YSEQLTVQGLFHKAASYLLVCNKVEEAIQLLVNNKCFREAMCIAKSRLDS DDPTINNVFIEWGNKLGNSDGNFVQAAECYLASGELDLAAKMFAKKKTAE YLKLSALVSRKCGNYALALSQAKQCFQECMHQENWDLADDIVSEYMELK- -----------------------PYHLVVIVHREVLNLLAADQGKFGSWL LGNRLIDTSLLERVASRWQTDDKQTVYSELHSGLDHNQSAQQTLNQMWLC VSKELSLSFSSEEKGLWHLVNAVAICYRYQLLHPSQPVLLQLCSWLAPAG PFTKGSVFLLSSQDTSNMSFVHSLRAFLGAAIAFWLDIVVKLSEDLEQQS PLGVNGKSKNDNEQITEPNQECGAHTRDLINDKNITIKSQEINKSITVIE SAEGMTDTQKVVEGVKEEVNDILEKIINVCGNKPNKEIKCNEKDDTKTKT NKEFIESKIDISSSNIDASKITCVGVSDETTCVFEHSGSLNWAAVCTVLE ELLVDVLDKHSTQYFQNEIEIKKLELLVAGAVASTRKSSALGESPKHIED NNVAEDRNENKIDDAINHNMRIEVTEAHTENGVVEGKKKDQVLFDTISDT NIIKNSILNEDNQTIADAQFGTGYSVLRGNSYLNEGEPTPTAAHLVQGHN SRDTFANSGLLKLKELKNCKEKFEMEKVA--------------------- -------VPNPFFIYCKVQTICQNVIMKKEPQLGQRLLDLLKNSL >Tsi M-------------------------------------RNDLIVCRHKFR GxLADGPQVQMIRVAHKEKVTVVRLSKTNGGKYPLSVATVGDDSIVKLWH LETLSLLQAHNFHEGSKVVDMDWSIADPNLVVSVDENNNIICWNLSTNST QRLTLFKLRAMCLACCPHKADTIAVGSRTGLVFVIKNKDGGQVLYRMRGH DSEVVSIAWCPVSYNIFKKSKTEQLLSRDMLLASAGKDRDVYIWRAGTDG QCQTKFNLPVTLVATMESSGHYRSGGSNAPSVGMFRMCLRWPEPSTLLTS TAWGELLKWRLTETGEDAAHKGYNYACRSKKPVQDKLSKNYQLLHNVHLR GLFSIACTPAIVQDETANFWTSSTDSVPSEDNLNSEEKEVSIDGMNxAKE QQLVWTTAQDRFIVACNLKTGKLVAKIPTFGGFVYAVAVSPVDSDRLAIG VGDSTIRIWNLSNSNAxDLVSMWQRVKSRxxTLAWHxTKENLLAxxxSEG RIGVCDTSSxxxPIVFKxSHQKxxxxxxWGPFxxxxx------------- -----------------------------EDPKNIPELVLYSCAVGEIFQ HNxxx----xDEVHPTEIRASISPSSAVELNTTNALAxxxxxxDISSFLK EIQQSVNPTSSKFKLTTELAWKPDFTLLALGLDDGTVHVFSAPHLTHLHT LFTIKKMIQCLAWHPESTATDTGLSPYQHWLAVSSNERTITVVDTLKLTK GESDINNKTIKSCITLTGHLNRVVSMAWSPHVSGQLVSVSFDDTAQVWDV PNQSLIANFPSHDSNLLCCVWSPLDPDMIITGSADCTLRIWKISSQTNKF PKEKxxxxKNKKLTDILIVEATRERNEEKQRHTFEHDTGKKAASSLPVNS QASTEVFDINDRA------------------------------------- ---------------------------------DHLTPRVISHINKKSFF PVSSRRRDDDSYQIENCYRLLERGGQDEIINKDTPPEEGGELGFHRFYGN REDIHKLINAEVADHRAKGREMFVSHMELWKGNTGEMLREASQKKALNDW LVSLAPSISHR-------------------------------VWVEMCVA YSEQLTAQGLFHKAASYLLVCNKVEEAIHLLVNNKCFREAMCIAKSRLDS DDPTINNVFIEWGNKLGNSD-------------GELDLAAKMFAKKKTVE YLKLSALVSRKCGNYALALSQAKQCFQECMHQENWDLADDIVSEYMELKN GNGIRNDSKYWVQERREDNDDFxPYHLVVIVHREVLNLLAADQGKFGSWL LGNRLVHTSLLERVASRWQTDDKQTVYCELRSGLDHNQSAQQTLNQMWLC VSKELSLSFSSEEKGLWHLVNAVAICYRYQLLHPSQPVLLQLCSWLAPAG PFTKDSVFLLSSQDTSNMSFVHSLRAFLGAAIAFWLDIVVKLSEDLEQQS ALGVNVKSKNDNEQITEPNEECDAHTRDLINDKNITIKAQEIIKSRTVIE SAEGLTDTQKVVEGVKEEVNDLLEKITKVCGNKPNKEIKCHEKDDTKTKT NNEFIELKIDISSSNIDASKITCVGVSNETT--FEHSGSLNWAAVCTVLE ELLVDVLDKHSTQYFQNEIEIKKLELLVAGAVASTRKSSALGESPKHIED NNVAGDRNENKIDDAINHNLQIEVTEAQTENGVVEGKKKDQVLFDTISDT NIIKNTILNEDNQTIADAQFGISYAVLRGNSYLNEVEPTTTAANFVQGHK SRDTIANSGLLKLQELKICKEKFEMEKVA--------------------- -------VPNPFFIYCKVQTICQNVIMKKEPQLGQHLLDLLKNSM >Tcm xxx------NEITIPPSPNWYLGDILSCNNDGVFVYGSRNDLIVCRHKFR GxLADGPQVQMIRVAHKEKVTVVRLSKTNGGKYPLSVATVGDDSIVKLWH LETLSLLQAHNFHEGSKVVDMDWSIADPNLVVSVDENNNIICWNLSTNST QRLTLFKLRAMCLACCPHKADTIAVGSRTGLVFVIKNKDGGQVLYRMRGH DSEVVSIAWCPVSYNIFKKSKTEQLLSRDMLLASAGKDRDVYIWRAGTDG QCQTKFNLPVTLVATVESSGHYRSGGSNAPSVGMFRMCLRWPEPSTLLTS TAWGELLKWRLTETGEDAAHKG------SKKPVQDKLSKNYQLLHNVHLR GLFSIACTPAIVQDETANFWTSSTDSVPSEDNLNSEEKEVSIDGMNxAKE QQLVWTTAQDRFIVACNLKTGKLVAKIPTFGGFVYAVAVSPVDSDRLAIG VGDSTIRIWNLSNSNAxDLVSMWQRVKSRxxTLAWHxTKENLLAxxxSEG RIGVCDTSSxxxPIVFKxxxQKxxxxxxWGPFxxxxx------------- -----------------------------EDPKNIPELVLYSCAVGEIFQ HNxxx----xDE-------------------------------DISSFLK EIQQSVNPTSSKFKLTTELAWKPDFTLLALGLDDGTVHVFSAPHLTHLHT LFTIKKMIQCLAWHPESTATDTGLSPYQHWLAVSSNERTITVVDTLKLTK GESDINNKTIKSCITLTGHLNRVVSMAWSPHVSGQLVSVSFDDTAQVWDV PNQSLIANFPSHDSNLLCCVWSPLDPDMIITGSADCTLRIWKISSQTNKF PKEK--------------------------------NTGKKAASSLPVNS QASTEVFDINDRA------------------------------------- ---------------------------------DHLTPRVISHINKKSFF PVSSRRRDDDSYQIENCYRLLERGGQDEIINKDTPPEEGGELGFHRFYGN REDIHKLINAEVADHRAKGREMFVSHMELWKGNTGEMLREASQKKALNDW LVSLAPSISHR-------------------------------VWVEMCVA YSEQLTAQGLFHKAASYLLVCNKVEEAIHLLVNNKCFREAMCIAKSRLDS DDPTINNVFIEWGNKLGNSDGNFVQAAECYLASGELDLAAKMFAKKKTVE YLKLSALVSRKCGNYALALSQAKQCFQECMHQENWDLADDIVSEYMELK- -----------------------PYHLVVIVHREVLNLLAADQGKFGSWL LGNRLVHTSLLERVASRWQTDDKQTVYCELRSGLDHNQSAQQTLNQMWLC VSKELSLSFSSEEKGLWHLVNAVAICYRYQLLHPSQPVLLQLCSWLAPAG PFTKDSVFLLSSQDTSNMSFVHSLRAFLGAAIAFWLDIVVKLSEDLEQQS ALGVNVKSKNDNEQITEPNEECDAHTRDLINDKNITIKAQEIIKSRTVIE SAEGLTDTQKVVEGVKEEVNDLLEKITKVCGNKPNKEIKCHEKDDTKTKT NNEFIELKIDISSSNIDASKITCVGVSNETT--FEHSGSLNWAAVCTVLE ELLVDVLDKHSTQYFQNEIEIKKLELLVAGAVASTRKSSALGESPKHIED NNVAGDRNENKIDDAINHNLQIEVTEAQTENGVVEGKKKDQVLFDTISDT NIIKNTILNEDNQTIADAQFGISYAVLRGNSYLNEVEPTTTAANFVQGHK SRDTIANSGLLKLQELKICKEKFEMEKVA--------------------- -------VPNPFFIYCKVQTICQNVIMKKEPQLGQHLLDLLKNSM