>Tge xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx xxxxxxxxxxxxxxxxxxxxxxxxxxx------xDNSPPKYMKKSAYKKP LVALGTASGNISVYSMAAGTILCGLIGVHTTRINTLSWSKGTNLFSAGDD GLIVEWDVCCKKVVSKWKANESSVTCLLALPGGENLLSAHHKITLWCIAS KFIIKTFYGHATEVTRLSLVRSGTSYCVSAARDDRYISVWPLVIKNKEKH CVAQLISNDPCVNLSVMGDELTNIGIVTRTGVLQIFRHHLNGKRTRPLKP DLTLQMATSGGKGSSSEPLPIVGTHLCDPTTAIVAYGQSGLFRFEK---- -IxxxHxTPxxxxxxxxxxxxxxxxxxALRHExxxxxxxxxxxxxxDTRx xxxxxxETPASRQTRDSCLQxxxxxxxxDxxxxxxxxxxxxxxxxxTxxx xxxxxxxxxTDxRLLLADIHETPACRxxxxxxxxxxxxxxxxxxxxxxxx xxxRDSYLQTDTRLLLADFVL----------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------STSSSTEMVCLV REALTKVSQKQEKAAMTKVVVPLVDDSAEYVSAAAVGSNKRVHEPGLTEV AMEERLDNLSLDQFSYDSTRGPPKPDNLVQLLLQGLKSKDPLILHSVLLR KDEQLIFNTVSRLPLKTVAPLLTELCTLLRSKSQKNHMVVPWLKAMLAVH AGQLLSNPELSQLLAPLLSLIEARLGQLTPLMRLRGRLELLVGQIGTIAD SNELQDSLLVYREQGSSDEDDLMETLGGSDNEDSSSRWSEEDEEQKNMST >Tpa xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx x------------------------------------------------- -------------------------------------------------- -------------CSKWKANESSVTCLLALPGGENLLSAHHKITLWCIAS KFIIKTFYGHATEVTRLSLVRSGTSYCVSAARDDRYISVWPLVIKNKEKH CVAQLISNDPCVNLSVMGDELTNIGIVTRTGVLQIFRHHLNGKRTRPLKP DLTLQMATSGGKGSSSEPLPIVGTHLCDPTTAIVAYGQSGLFRFEKxxxx xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- >Tms ----------------------------------------------xSST ECSAFSEDGKYFGYCGDDGKLKIWETDTGTLKKEYIPNLHLSEPCTCLTW LLNIKHS------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------DNSIPKYKKKSVGKKP LVALGTAAGNISVYSMAAGTVLSGLIGVHTTRLNTLSWSKGTNLFSAGDD GIIVEWDVCCKKVVSKWKANESSITCLLVLPGGENLLSAHHRITLWCIAS KFIIKTFYGHATEVTRLSLVRIGTSYCVSAARDDRYISVWPLVIKNQEKH CVAQLISNDPCVDLSVMGDELTNIGVVTRTGALQIFRHHLNGKRTRPLKP DLTLQMATSGGKDSSSEPLPIVGTHLCEPTTAIVAYGQSGLFRFER---- -I------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------STSSSTEMVCLV RDAPTKGSHKREKVAMTKVVVPLVDDSAEYVSAAAVGSNKRVREPGLTEV AMEERLDNLSLNQFSYDSTRGPPKPDNLVQLLLQGLKSKDTLILHSVLLR KDEQLIFNTVSRLPLRTVAPLLTELCTLLQSKSQRNHMVVPWLKAMLAVH AGQLLSNPELSQMLAPLLSLIEARLGQLTPLMRLRGRLELLVGQIGAISD TNELQDSLLVYREQGSSDEDDLMETLGGSDNEDSSSRWSEEDEEQKNMST >Tce ----------------------------------------------xSST ECSAFSEDGKYFGYCGDDGKLKIWETDTGTLKKEYIPNLHLSEPCTCLTW LLNIKHS------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------DNSIPKYKKKSVGKKP LVALGTAAGNISVYSMAAGTVLSGLIGVHTTRLNTLSWSKGTNLFSAGDD GIIVEWDVCCKKVVSKWKANESSITCLLVLPGGENLLSAHHRITLWCIAS KFIIKTFYGHATEVTRLSLVITGTSYCVSAARDDRYISVWPLVIKNQEKH CVAQLISNDPCVDLSVMGDELTNIGVVTRTGALQIFRHHLNGKRTRPLKP DLTLQMATSGGKDSSSEPLPIVGTHLCEPTTAIVAYGQSGLFRFER---- -Ix----------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------xxxxARHxxxxxxxx--------------- -------------------------------------------------- ----------------------------------ARHYCQTLETVARHYC QTLxxxxxxxxxxxxTVVRxTSQTLETVARHYCQTLETSTSSSTEMVCLV RDAPTKGSHKREKVAMTKVVVPLVDDSAEYVSAAAVGSNKRVREPGLTEV AMEERLDNLSLNQFSYDSTRGPPKPDNLVQLLLQGLKSKDTLILHSVLLR KDEQLIFNTVSRLPLRTVAPLLTELCTLLQSKSQRNHMVVPWLKAMLAVH AGQLLSNPELSQMLAPLLSLIEARLGQLTPLMRLRGRLELLVGQIGAIAD TNELQDSLLVYREQGSSDEDDLMETLGGSDNEDSSSRWSEEDEEQKNMST >Tsi ----------------------------------------------xSST ECSAFSEDGKYFGYCGDDGKLKIWETDTGTLKKEYIPNLHLSEPCTCLTW LLNINHS------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------DTSLTKFKRKSVGKKP LVALGTAAGNISVYSMVAGTVLSGLIGVHTTRLNTLSWSKGTNLFSAGDD GIIVEWDVCCKKVVSKWKANESSVTCLLALPGGENLLSAHHRITLWCIAS KFIIKTFYGHATEVTRLSLVRTGTSYCVSAARDDRYISVWPLVIKNQEKH CVAQLISSDPCVNLSVMDDELTNIGVVTRTGALQIFRHHLNGKRTRPLKP DLTLQMATSGEKGSGSEPLPIVGTHLCEPTTAIVAYGQSGLFRFER---- -I------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------STSSSTEMVCLV REALAKSSRKREKAAMNKVVVPLVDDSAEYVSAAAVGSNKRVREPGLTEV AMEERLDNLSLNQFSYDSARGPPKPDNLVQLLLQGLKSKDPLILHSVLLR KDEQLIFNTVSRLPLRTVAPLLTELCTLLQSKSQRNHMVVPWLKAMLAVH AGQLLSNPELSQMLAPLLSLIEARLGQLTPLMRLRGRLELLVGQIGAVAD SNEPQDSLLVYREQGSSDEDDLMETLGGSDNEDSSSRWSEEDEEQKNMST >Tcm ---------------------------------------------NxSST ECSAFSEDGKYFGYCGDDGKLKIWETDTGTLKKEYIPNLHLSEPCTCLTW LLNINHS------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------DTSLTKFKRKSVGKKP LVALGTAAGNISVYSMAAGTVLSGLIGVHTTRLNTLSWSKGTNLFSAGDD GIIVEWDVCCKKVVSKWKANESSVTCLLALPGGENLLSAHHRITLWCIAS KFIIKTFYGHATEVTRLSLVRTGTSYCVSAARDDRYISVWPLVIKNQEKH CVAQLISSDPCVNLSVMDDELTNIGVVTRTGALQIFRHHLNGKRTRPLKP DLTLQMATSGEKGSGSEPLPIVGTHLCEPTTAIVAYGQSGLFRFER---- -I------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------STSSSTEMVCLV REALAKSSRKREKAAMNKVVVPLVDDSAEYVSAAAVGSNKRVREPGLTEV AMEERLDNLSLNQFSYDSARGPPKPDNLVQLLLQGLKSKDPLILHSVLLR KDEQLIFNTVSRLPLRTVAPLLTELCTLLQSKSQRNHMVVPWLKAMLAVH AGQLLSNPELSQMLAPLLSLIEARLGQLTPLMRLRGRLELLVGQIGAVAD SNEPQDSLLVYREQGSSDEDDLMETLGGSDNEDSSSRWSEEDEEQKNMSA >Tdi x--SKPSWSEHQVLIHQGKVAPLLDLGRFEVSQVTRLCKTVYPKANxSST ECSAFSEDGKYFGYCGDDGKLKIWETDTGTLKKEYIPNLHLSEPCTCLTW LLNINHSVPTEASGMRKSRKLREHREFASKYKVVSGGKQSNDPEQEETKQ RPRTRGNKATTQNKRKLSNDPEQEETKQRPRTRGNKATTQNKRKQSNDPE QEETKQRPRTRGNKATTQNKRKQSNDPEQEETKQRPRTRGNKATTQNKRK QSNDPEQEETKQRPRTRGNKATTQNKRKQSNDPEQEETKQRPRTRGNKAT TQNKRKQSNDPEQEETKQRPRTRGNKATTQNKRKQSNDPEQEETKQRPRT RGNKATTQNKRKQSNDPEQEETKQRPRTRGNKATTQNKRKQSNDPEQEET KQRPRTRGNKATTQNKRKQSNDPEQEETKQRPRTRGNKATTQNKRKQSND PEQEETKQRPRTRGNKATTQNKRKQSNDPEQEETKQRPRTRGNKATTQNK RKQSNDPEQEETKQRPRTRGNKATTQNKRKQSNDPEQEETKQRPRTRGNK ATTQNKRKQSNDPEQEETKQRPRTRGNKATTQNKRKQSNDPEQEETKQRP RTRGNKATTQNKRKQSNDPEQEETKQRPRTRGxxxxxxxKRKQSNxxxxx xxxxRxxxxxxxxxxQNKxxxxxxxxxxExxxxxxxxxxxxxxxxxxxx- ---------------------------------xDTSLPKFKRKSVGKKP LVALGTAAGNISVYSMAAGTVLSGLIGVHTTRLNTLSWSKGTNLFSAGDD GIIVEWDVCCKKVVSKWKANESSVTCLLALPGGENLLSAHHRITLWCIAS KFIIKTFYGHATEVTRLSLVRTGTSYCVSAARDDRYISVWPLVIKNQEKH CVAQLISTDPCVNLSVMGDELTNIGVVTRTGALQIFRHHLNGKRTRPLKP DLTLQMATSGEKGSGSEPLPIVGTHLCEPTTAIVAYGQSGLFRFER---- -I------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------STSSSTEMVCLV REALTKSSRKREKAAMNKVVVPLVDDSAEYVSAAAVGSNKRVREPGLTEV AMEERLDNLSLNQFSYDSARGPPKPDNLVQLLLQGLKSKDPLILHSVLLR KDEQLIFNTVSRLPLRTVAPLLTELCTLLQSKSQRNHMVVPWLKAMLAVH AGQLLSNPELSQMLAPLLSLIEARLGQLTPLMRLRGRLELLVGQIGAVAD SNEPQDSLLVYREQGSSDEDDLMETLGGSDNEDSSSRWSEEDEEQKNMST >Tbi ---------------------------------------------NMSST ECSAFSEDGKYxGYCGDDGKLKIWETDTGTLKKEYIPNLHLSEPCTCLTW LLNIKHS------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------DNSPPKYMKKSAYKKP LVALGTASGNISVYSMAAGTILSGLIGVHTTRINTLSWSKGTNLFSAGDD GLIVEWDVCCKKVVSKWKANESSVTCLLALPGGENLLSAHHKITLWCVAS KFIIKTFYGHATEVTRLSLVRTGTSYCVSAARDDRYISVWPLVIKNKEKH CVAQLISNDPCVNLSVMGDELTNIGIVTRTGVLQIFRHHLNGKRTRPLKP DLTLQMATSGGKGSSSEPLPIVGTHLCESTTAIVAYGQSGLFRFER---- -I------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------STSSSTEMVCLV REALTKGSQKREKAAMTKVVVPLVDDSAEYVSAAAVGSNKRVREPGLTEV AMEERLDNLSLDQFSYDSTRGPPKPDNLVQLLLQGLKSKDPLILHSVLLR KDEQLIFNTVSRLPLKTVAPLLTELCTLLRSKSQKNHMAVPWLKAMLAVH AGQLLSNPELSQMLAPLLSLIEARLGQLTPLMRLRGRLELLVGQIGTxAD SNELQDSLLVYREQGSSDEDDLMETLGGSDNEDSSSRWSEEDEEQKNMST >Tps xxxxx--------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------DKSLPKFKKKNVVKKP LVALGTAAGNISVYSMATGTVLSGLIGVHTTRLNTLSWSKGTNLFSAGDD GIIVEWDVCCKKVVSKWKTNESSVTCLLALPGGENLLSAHHRITLWCIAS KFIIKTFYGHATEVTRLSLVRTGTSYCVSAARDDRYISVWPLVIKNQEKH CVAQLISSDPCVNLSVTGDELTNIGVVTRTGALQIFRHHLNGKRTRPLKP DLTLKMATCGEKGSGSEPLPIVGTHLCEPTTAIVAYGQSGRFRFERxxxx xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- >Tte x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xxxxxxxxDNSPPKYMKKSAYKKP LVALGTASGNISVYSMAAGTILSGLIGVHTTRINTLSWSKGTNLFSAGDD GLIVEWDVCCKKVVSKWKANESSVTCLLALPGGENLLSAHHKITLWCVAS KFIIKTFYGHATEVTRLSLVRTGTSYCVSAARDDRYISVWPLVIKNKEKH CVAQLISNDPCVNLSVMGDELTNIGIVTRTGVLQIFRHHLNGKRTRPLKP DLTLQMATSGGKGSSSEPLPIVGTHLCESTTAIVAYGQSGLFRFER---- -Ixxxx-------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------------