>Tge -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------xxxxxxxxxxxxxxxxxxxDKS IRKKRHETQHPGIEENHQVKLLLDRLEKSGISANKLSPSLWKHISDCYSG ADCSSAVSKGIVTQLVGLPAVKVFRLPIGGKIKRLKSNLCNDIEDYTPKS KFTHQDTGQSIIKRSKNIRKTKKRTKPCGDTSFGT-AQQSTLENVDHSSA HLDSNHDTLSNPDIEQSLQVRSNACTKSATAPSLDLEDFELECVLPKFVI TKDNPILTESKDSDQEVNNESNHSPEGSTSPIQKSIVQCGDSTEHNEIIS TKEEPIDIVEDIYETEFVSVSEDFNQKLTPELNISAKTEKETEFVEVEEM FDGKSTTEPRDIPIVREESHFIIVDTASQDIKTESIWDSNSFELLEARSN DSNILDKAHTDVPPTDSVIGNDAERIIDYTDTNDNIESEPFDNCDQPTFS VSSSLWQKPITNTSPL---------------------------------- --------------RANILDPVLEYEINQDIPTAQKRSGTINLQPAVPQK TRKIAPKQIPTQH------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxx---------------------- --------------------------------------NTATSQSSVETD VYRQEADDLFYNIYSSSNTISNSKSLKNVELENNPILENTT--------- --DDDNDNGWESCENNFEDENRHNSNVETCGQVDVQIGDSENFEKYILRS ANKIICKLCEKSFEQNEEYKSHMKLHLKASHFFCRKCKIDVPIISFLNFH LNSCMKNLPPKDLVVLSSDDEPEPTPEANYKCKVCGEKFGFRINLKYHKE TH------------------------------------------------ -------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- --------------------------------- >Tbi x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------xxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxLNV------------------------------------ -------------------------------xxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxDKS IRKKRHETQHPGIEENHEVKLLLDRLEKTGISANKLSPALWKHISDCYSG ADCSSAVSKGIVTQLVGLPAVKVFRLPIGGKIKRLKSNLCNVIEDSTPKS KFTHQDTGQSIIKTTKNIRKTKKRTKPCGDTSFGTxAQQSTLENVDNSSA PLDSNRDTLSNPDIEQSLQVRNNACTKIATAPPPDLEDFELECVLPKFVI TKDNPVLTESKDSDQEVNNKSNHCPEGSTSPIQKSIVQCGDSTEHNEIIS TKEEPIDIVEDIYETEFVSVSEDFNQKLTPELNVTAKTEKETEFVEVEEM FDGKSTTEPRDIPIVREESHFIIVDTASQDIKTESIWDSNSFELLEARSN DSNILDKAHTDVPPTVSVIGNDAERIIDYTDTNDNIESEPFDNCDQPTFS VSSSLWQKHIANTSPL---------------------------------- --------------RANLLDPVLEYEINQDIPTALKRSGAINLQPAVPQK TRKIAPKQIPTQQSIYTATNPNNSGxxEGVxxxxxxxxQxxxQQPSIAAP QTKIQQDTIISFxxxxxxxxxPVSLQDVSNTKYQPLHASISLVSASNVHP EMKPRAYSQN---------------------------------------- --------------SLHTLNNIKQPSLDNLQSPVVPSVVSQASTMARSSW HVVQKDCNEMIAVGPPHTLGMQITNDTVNPxDDVTKASxxxxxxxx---- -------------------------------------------------- ----------------------------xxxxPRWDSQSQITLPQNHVTT Axxxxxxxxxxxxxx--------QSTTVVIPSDSDSCRNTATSQSSVETD VYRQEADDLFYNIYSSSNTISNSKSLKNVELENNPILENTT--------- --DDDNDNGWESCENNFEDENHHNSNVETCGQVDVQIGDSENFEKYILRS ANKIICKLCEKSFEQNEEYKSHMKLHLKASHFFCRKCKIDVPIISFLNFH LNSCMKNLPPKDLVVLSSDDEPEPTPEANYKCKVCxxxFGFRINLKYHKE TH------------------------------------------------ -----------------------------------------------xxx xxxxSxxxxxSxVLGTDLSESxxxWLQVASQxxxxxxVHTLCINVV---G QL------------------------------------------------ -------------------------------------HWFDVTIRSGL-- -------------------------------------------------- -------------------PDGRLATRxxxxxxxxxxxxxxxxxxxxLDK PVxxxxxxxxxxxxxxIINxxxxxxxSNAKFGIADVLMIRVFHxxxxxxx xxxxxxxxxxxxxxxxxxxxETELIPALKEVGVIxxxxxxxxxxxxxxxx xxxxxxxxxxSRSSRQILLRLLLETFPVRFDLN >Tte x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------xxPQGGSRxxERQxxxxxxx xxxxKxxPxYxxxx------------------------------------ -------------------------------xxxxx-------------- ----------------------------xxxxxxxxxxxxxxxxxxxDKS IRKKRHETQHPGIEENHEVKLLLDRLEKTGISANKLSPALWKHISDCYSG ADCSSAVSKGIVTQLVGLPAVKVFRLPIGGKIKRLKSNLCNVIEDSTPKS KFTHQDTGQSIIKTTKNIRKTKKRTKPCGDTSFGTxAQQSTLENVDNSSA PLDSNRDTLSNPDIEQSLQVRNNACTKIATAPPPDLEDFELECVLPKFVI TKDNPVLTESKDSDQEVNNKSNHCPEGSTNPIQKSIVQCGDSTEHNEIIS TKEEPIDIVEDIYETEFVSVSEDFNQKLTPELNVTAKTEKETEFVEVEEM FDGKSTTEPRDIPIVREESHFIIVDTASQDIKTESIWDSNSFELLEARSN DSNILDKAHTDVPPTVSVIGNDAERIIDYTDTNDNIESEPFDNCDQPTFS VSSSLWQKHIANTSPL---------------------------------- --------------RANLLDPVLEYEINQDIPTALKRSGAINLQPAVPQK TRKIAPKQIPTQQSIYTATNPNNSGLQEGVNTVVEGFSQPISQQPSIAAP QTKIQQDTIISFQQLEENKNLPVSLQDVSNTKYQPLHASISLVSASNVHP EMKPRAYSQN---------------------------------------- --------------SLHTLNNIKQPSLDNLQSPVVPSVVSQASTMARSSW HVVQKDCNEMIAVGPPHTLGMQITNDTVNPSDDVTKASAHxxxxxxxxxx xANHxxxxxxxYCCSESFAEYSFNHSFTDKKDALxxxxxxxxxxxxxSFx xxKKxxxxxxxxxxxxxxxxxxxxxxxx---------------------- --------------------------------------NTATSQSSVETD VYRQEADDLFYNIYSSSNTISNSKSLKNVELENNPILENTT--------- --DDDNDNGWESCENNFEDENHHNSNVETCGQVDVQIGDSENFEKYILRS ANKIICKLCEKSFEQNEEYKSHMKLHLKASHFFCRKCKIDVPIISFLNFH LNSCMKNLPPKDLVVLSSDDEPEPTPEANYKCKVCGEKFGFRINLKYHKE TH------------------------------------------------ -------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxSSDGAAxLVLGTDLSESxxxWLQVASQxxxxxx------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------xxxxxxxxxxxxxxxxxxxxLDK PVxxxxxxxxxxxxxxIINxxxxxxxSNAKFGIADVLMIRVFHxxxxxxx xxxxxxxxxxxxxxxxxxxYETELIPALKEVGVIxxxxxxxxxxxxxxxx xxxxxxxxxISRSSRQILLRLLLETFPVRFDLN >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------DKS IRKKRHETQHPGIEENHQVKLLLDRLEKAGISANKLSPSLWKHISDCYSG TDCSSAVSKGIVTQLVGLPAVKVFRLPIGGKIKRLKSNLCNVIEDSTPQ- -------------------------------------------------- -------------------------------------------------- --------KSKDSDQEVNNESNHSPERLTSPIQKSIVQCGDSTEHNEIIS TKEEPIDIVEDIYETEFVSVSEDFNQKLTPELNVTAKTEKETEFVEVEEM FDGKSTTEPRDIPIVREESHFIIVDTASRDIKTESIWDSNSFELLEARSN DSNILDKAHTDVPPTDSVIGNDAERIIDYTDTNDNIESEPFDNCDQPTFS VSSSLWQKPITNTSPL---------------------------------- --------------RANLLDPVLEYEINQDIPTAQKRSGAINLQPAVPQK TRKIAPKQIPTQQSIYTATNPNNSGLQEGVNTVVEGFSQPISQQPSIAAP QTKIQQDTIISFQQLEENKNLPVSLQDVSNTKYQPLHASISLISASNVHP EMKPLAYSQNxxxYEIMGVRTFENRPKEYVLNPIDGNYTPVVDVYQPLSx xxxxxxxxxxxxxxSLHTLNNIKQPSLDNLQSPVVPSVVSQASTMARSSW HVVQKDCNEMIAVVPPHTLGMQITNDTVNx-------------------- -------------------------------------------------- -------------------------------------------------- ------------------------STTVVIPSDSDSCRNTATSQSSVETD VYRQEADDLFYNIYSSSNTISNSKSLKNVELENNPILENTTND------- --DNDNDNGWESCENNFEDENHHNSNVETCGQVDVQIGDSENFEKYILRS ANKIICKLCEKSFEQNEEYKSHMKLHLKASHFFCRKCKIDVPIISFLNFH LNSCMKNLPPKDLVVLSSDDEPEPTPEANYKCKVCGEKFGFRINLKYHKE THxxNKAKYxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxTF KLLIExxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--- ---------------------------------------------xxxxx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------- >Tps xx------------------------------------------------ -------------------------------------------------- -------------------------------------------------- ----xxxxxxxxDERxxxxxxxxxxxxxxxxxSQDGxxxxERKxxxxxxx xxxxKxxPxYxxxxxxxxxxxxxxxxxxxxxxxxxxxxxDxxxxxxxxxx xxxxxxxxxxQxxxEQTQxxxxxxxxxTGDCL------------------ -----------------------------------------------DKS IRKKRHETQHSGIEENHQVKLLLNRLEKTGISVNKLSPSLWKHISDCYSG ADYCSAVSKGIVTQLVQLPAVKVFRLPIGGKIKRLKSNLCNVIQETTPKS KFTHQDNGQDIIKVTKNTCKTKKRTKPCVDTSFGT-AQQSTLENLDHSNA QLDSNHDTLSNPVIEQSLHVRSNACTKSATPPPLDLEDFELECVLPKFVI TKDNPILTGSKDSDQEVSNESNHCPERSTSPIQKSIVQCSDSTEHIEMVS TKEESIDIVEDIYEPEFVSVSEDFDQKLTPDFNITAKTEKETEFVDVGEI FDNKSTTKPCDIPLVREESHFIIVDTASQAIKTESIWDGNSFELLEARSN DSNILDKAHTDVPPTGLVNGNDAERIIDYTDTNDNIESGPLDNCDKPTFS VSSSLWQKHIGNASLP---------------------------------- --------------RANLLDSVLEHEINQDIPTAQKRSGAIDVQPVVPLK TRKIAPKKIPIQQLMYNATNPNNSGLQKDVITVIEGFSQPISQQRSIVAP QTKIQQDTIIK--------------------------------------- -------------------------------------------------- ----xxxxxxxxxxSLYTLNNIKQPSLDNLQSPVVASVASQASTMARSSW HVVQKDCDEMLPTVLPHTLGMQITNETVNPSEDVTKASAHxxxxxx---- -------------------------------------------------- -------------------------------------------------- ------------KPxxxxxxTTDIGTTVIIPSDSDNCRNIVSSQSSVETD IYRQEADDLFYNIYSSSSTISNSKSLKRVELENNPILENTMDDD------ NNDNDNDNGWESYENNFEDENQHNSNIETCGQVDVQIGDSENYEKYILRS ENKIICKLCEKSFEQNEEYKSHVKLHLKASHFFCRKCKIDVPIISFLNFH LNSCMKTLPPKDLVVLSSDDEPEPTPEANYKCKVCGEKFGFRINLKYHKE THxxNKAKYxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxTF KLLIExxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--- ---------------------------------------------xxxxx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------- >Tdi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xxxxxxSQGGxxxxERKxxxxxxx xxxxKxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxDxxxxxxxxxx xxxxxxxxxxQxxxEQTQxxxxxxxxxTGDCL------------------ -----------------------------------------------DKS IRKKRHETQHSGIEENHQVKLLLNRLEKTGISVNKLSPSLWKHISDCYSG ADYCSAVSKGIVTQLVQLPAVKVFRLPIGGKIKRLKSNLCNVIQETTPKS KFTHQDNGQDIIKVTKNTCKTKKRIKPCVDTSFGT-AQQSTLENLDHSNA QLDSNHDTLSNPVIEQSLHVRSNACTKSATPSPLDLEDFELECVLPKFVI TKDNPILTGSKDSDQEVSNESNHCPERSTSPIQKSIVQCSDSTEHIEMVS TKEESIDIVEDIYEPEFVSVSEDFDQKLTPDFNITAKTEKETEFVDVGEM FDNKSTTKPCDIPLVREESHFIIVDTASQAIKTESIWDGNSFELLEARSN DSNILDKARTDVPPTGLVNGNDAERIIDYTDTNDNIESGPLDNCDKPTFS VSSSLWQKHIGNASLPxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------KPSxxxxxTTDIGTTVIIPSDSDNCRNIVSSQSSVETD IYRQEADDLFYNIYSSSSTISNSKSLKRVELENNPILENTMDDD------ NNDNDNDNGWESYENNFEDENQHNSNIETCGQVDVQIGDSENYEKYILRS ENKIICKLCEKSFEQNEEYKSHVKLHLKASHFFCRKCKIDVPIISFLNFH LNSCMKTLPPKDLVVLSSDDEPEPTPEANYKCKVCGEKFGFRINLKYHKE THxxNKAKYxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxTF KFLIExxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--- ---------------------------------------------xxxxx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------- >Tsi xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxTLVVQTPVEGTxxx xxxxxxxxxxxxxxxxSYRIICVSxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxEAGRCxxxxxx xxxxx--------------------------------------------- -----------------------------------xxxxDxxxxxxxxxx xxxxxxxxxxQxxxEQTQxxxxxxxxxTGDCL------------------ -----------------------------------------------DKS IRKKRHETQHSGIEENHQVKLLLNRLEKTGISVNKLSPSLWKHISDCYSG ADYCSAVSKGIVTQLVQLPAVKVFRLPIGGKIKRLKSNLCNVIQENTPKS KFTHQDSGQDIIKVTKNTCKTKKKTKPCVDTSFGT-AQQSTLENLDHSNA QLDSNHDTLSNPVIEQSLHVRSNACTKSA---PLDLEDFELECVLPKFVI TKDNPILTGSKDSDQEVSNESNHCPERSTSPIQKSIVQCGDSTEHIEMVS TKEESIDIVEDIYEPEFVSVSEDFDQKLTPDFNITAKTEKETEFVDVGEM FDNKSTTKPCDIPLVREESHFIIVDTASQAIKTESIWDGNSFELLEARHN DSNVLDKAHTDVPPTGLVNGNDAERIIDYTDTNDNIESGPLYNCDKPTFS VSSSLWQNHIGNTSLP---------------------------------- --------------RANLLDSVLEHEINQDIPTAQKRSGAINLQPVVPLK TRKIASKKIPIQQLI----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------xxxxxxxx----- ------------KPSxxxxxTTDIGTTMIIPSDSDNCRNIVTSQSSVETD IYRQEADDLFYNIYSSSSTISNSKSLKRVELENNPILENTMDDDxxxxxx DNDNDNDNGWESYENNFEDENQHNSNIETCGQVDVQIGDSENYEKYILR- ---------------------------------------------FLNFH LNSCMKTLPPKDLVVLSSDDEPEPTPEANYKCK----------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------x xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx --------------------------------- >Tcm xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxTLVVQTPVEGTxxx xxxxxxxxxxxxxxxxSYRIICVSxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxEAGRCxxxxxx xxxxx--------------------------------------------- -----------------------------------xxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxTGDCL------------------ -----------------------------------------------DKS IRKKRHETQHSGIEENHQVKLLLNRLEKTGISVNKLSPSLWKHISDCYSG ADYCSAVSKGIVTQLVQLPAVKVFRLPIGGKIKRLKSNLCNVIQENTPKS KFTHQDSGQDIIKVTKNTCKTKKKTKPCVDTSFGT-AQQSTLENLDHSNA QLDSNHDTLSNPVIEQSLHVRSNACTKSA---PLDLEDFELECVLPKFVI TKDNPILTGSKDSDQEVSNESNHCPERSTSPIQKSIVQCGDSTEHIEMVS TKEESIDIVEDIYEPEFVSVSEDFDQKLTPDFNITAKTEKETEFVDVGEM FDNKSTTKPCDIPLVREESHFIIVDTASQAIKTESIWDGNSFELLEARHN DSNVLDKAHTDVPPTGLVNGNDAERIIDYTDTNDNIESGPLYNCDKPTFS VSSSLWQNHIGNTSLP---------------------------------- --------------RANLLDSVLEHEINQDIPTAQKRSGAINLQPVVPLK TRKIASKKIPIQQLI----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-----xxxxxxxxxx----- ------------xxxxxxxxxxxIGTTMIIPSDSDNCRNIVTSQSSVETD IYRQEADDLFYNIYSSSSTISNSKSLKRVELENNPILENTMDDD----DN DNDNDNDNGWESYENNFEDENQHNSNIETCGQVDVQIGDSENYEKYILR- ---------------------------------------------FLNFH LNSCMKTLPPKDLVVLSSDDEPEPTPEANYKCK----------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------x xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------xxx ---------------------------------