>Tge -------------------------------------------------- -------------------------------------------------- -----------------------------------------M-------- -------------------------------------------------- -------------------------------------------------x xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx- -------------------------------------------------- -------------------------------------------xIIQRAR NAFHSGRTKSVEFREKQLNQLLRLYEENVPEMLTALSSDLR--------- -----------------------------------------------KSK QESLMTEIEYMKNDLKNTIHNLREWAKPEKPPKGFVNMLDGVLIYNDPYG VVLIMGAWNYPLQLALLPMAGAIAAGNTVILKPSEVSPASAQLIAKLLPK YLD----QECFHVVLGGVPETTQLLKEKFDYIFYTGSTEVGKIVRRAANE HLTPVTLELGxxERMCCQMCMRTDLRWLVLRFDWFSCAKHLRQSGQSRDE LNFNGTARADKAEIxPVYLDNTADLEMAVKRIMWGKCINAGQTCIAPDYL LCSKQVEKEFVSKAKTILKEWYGEKSKESPDLCRIVTDRHYQRLVGLLKG GTVAVGGETDASEKFISPTILVDVKPTDPIMQEEIFGPILPVVNVESAFD AIKFINSR------------------KEPLTLYVFTTDKKVRELILSQTR SGSTCINDTLMHFV----------------------GESTxxxxxxx--- -----------------------------------------------EKP LAFYIFTKSSKDRDLLINNVSCGGVCCNDTIMHLTVDTLPFGGVGNSGIG SYHGKYSFDTFTHKKSCLVKDFNGLGEKLAAVPKFFFPVLITRSRYPPYS EKKIAMLGFLLKKRTGVSLKYLPHLVMY----AATFGFRAIAQPSNLHNx xVHPKLPDxxxSFHFNQHNKRCMKHRCNTCKIHPPSETFNSRxxxKQYPF QGHHxxxxxxxxxxxxxLxxxxxxxxxxxxxxxxxxxxxxxPVPSHxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxRx--------------------------- -------------------------------------------------- -------------------------------------------------- ----- >Tsi -------------------------------------------------- -------------------------------------------------- -----------------------------------------x-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------HECFQVVLGGVPETTQLLKEKFDYIFYTGSTEVGKIVRRAANE HLTPVTLELG----------------------------------GKS--- ---------------PVYLDNTADLEMAVKRIMWGKCINAGQTCIAPDYL LCSKQVEKEFVSKAKTILKEWYGDKSKESPDLCRIVTDRHYQRLVGLLKA GTVAVGGETDASEKFISPTILVDVKPTDPVMQEEIFGPILPVINVESAFE AIKFINSR------------------EEPLTLYVFTTDKKVRELILSQTR SGSTCINDTLMHFV----------------------xxxx------xxxx ---------------------------------------------xREKP LAFYIFSKSSKDRDLLINNVSCGGVCCNDTIMHLAVDTLPFGGVGNSGIG SYHGKYSFDTFTHKKSCLVKDFNGLGEKLA-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----- >Tce -------------------------------------------------- -------------------------------------------------- -----------------------------------------x-------- xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxx------------------------xxxxxxxxxxxxxxxxDIVQRAR NAFHSGRTKSVEFREKQLNQLLRLYEENVPEMLTALSSDLR--------- -----------------------------------------------KSK QESLMTEIEYMKNDLINTIHNLREWVKPEKPPKGFVNMLDGVLIYNDPYG VVLIIGAWNYPLQLALLPMAGAIAAGNTVILKPSEVSPASAQLIAKLLPK YLD----QECFQVVLGAVPETTQLLKEKFDYIFYTGSTEVGKIVRHAANE HLTPVTLELG----------------------------------GKS--- ---------------PVYLDNTADLEMAVKRIMWGKCINAGQTCIAPDYL LCSKQVEKEFVSKAKTILKEWYGDKSKESPDLCRIVTDRHYQRLVGLLKA GTVAVGGETDASEKFISPTILVDVKPTDPVMQEEIFGPILPVVNVESAFD AIKFINSRYVVKETDLIIPQLPDLETEEPLTLYVFTTDKKVRELILSQTR SGSTCVNDTLMHFVVISWFGDSLGTxxxxxxxxxxx-------------- ----------------------------------------------REKP LAFYIFSKSAKDRDLLINNVSCGGVCCNDTIMHLAVETLPFGGVGNSGIG SYHGKYSFDTFTHKKSCLVKDFNRLGEKLAA------------SRYPPYS EKKIAMLGFLLKKRAGVSLKYLPHLVMFGLGIAATFGFRAIAQ------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xLNTLDSQQPxSIRMNNHC LDI---NLKNLDKPLEYSEHxRQQxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxx------------------------------------ ----x >Tdi -------------------------------------------------- -------------------------------------------------- -----------------------------------------xxxxxxxxx x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------IVQRAR NAFHSGRTKSVEFREKQLNQLLRLYEENVPEMLTALSSDLR--------- -----------------------------------------------KSK QESLMTEIEYMKNDLINTIRNLREWVKPEKPPKSFVNMLDGVLIYNDPYG VVLIIGAWNYPLQLALLPMAGAIAAGNTVILKPSEVSPASAQLIAKLLPK YLD----QECFQVVLGGVPETTQLLKEKFDYIFYTGSTEVGKIVRHAANE HLTPVTLELG----------------------------------GKS--- ---------------PVYLDNTADLEMAVKRIMWGKCINAGQTCIAPDYL LCSKQVEKEFVSKAKTILKEWYGDKSKESPDLCRIVTDRHYQRLVGLLKA GTVAVGGETDASEKFISPTILVDVKPTDPVMQEEIFGPILPVVNVESAFD AIKFINSR------------------EEPLTLYVFTTDKKVRELILSQTR SGSTCINDTLMHFVAISWFDDSLGTxxxxxxxxxxx-------------- ----------------------------------------------REKP LAFYIFSKSSKDRDLLINNVSCGGVCCNDTIMHLAVDTLPFGGVGNSGIG SYHGKYSFDTFTHKKSCLVKDFNGIGEKLA-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----- >Tcm -------------------------------------------------- -------------------------------------------------- -----------------------------------------x-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------RIVQRAR NAFHSGRTKSVEFREKQLNQLLRLYEENVPEMLTALSSDLR--------- -----------------------------------------------KSK QESLMTEIEYMKNDLINTIRNLREWVKPEKPPKGFVNMLDDVLIYNDPYG VVLIIGAWNYPLQLALLPMAGAIAAGNTVVLKPSEVSPASAQLIAKLLPK YLD----QECFQVVLGGVPETTQLLKEKFDYIFYTGSTEVGKIVRRAANE HLTPVTLELG----------------------------------GKS--- ---------------PVYLDNTADLEMAVKRIMWGKCINAGQTCIAPDYL LCSKQVEKEFVSKAKTILKEWYGDKSKESPDLCRIVTDRHYQRLVGLLKA GTVAVGGETDASEKFISPTILVDVKPTDPVMQEEIFGPILPVINVESAFE AIKFINSR------------------EEPLTLYVFTTDKKVRELILSQTR SGSTCINDTLMHF------------------------------------- ------------------------------------------------KP LAFYIFSKSSKDRDLLINNVSCGGVCCNDTIMHLAVDTLPFGGVGNSGIG SYHGKYSFDTFTHKKSCLVKDFNGLGEKLAA------------SRYPPYS EKKISMLGFLLKKRAGVSLKYLPHLVMFGLGIAATFGFRAIAQD------ -------------------------------------------------- -------------------------------------------------- ---FDSxxx----------------------------------------- ----------------------xxxxxxxxxA------------------ -------------------------------------------------- ------xxxxxxxxxWExxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx PTSFA >Tps -------------------------------------------------- -------------------------------------------------- -----------------------------------------x-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxDIVQRAR NAFHSGRTKSVEFREKQLNQLLRLYEENVPEMLTALSSDLR--------- -----------------------------------------------KSK QESLMTEIEYMKNDLINTIRNLREWVKPEKPPKSFVNMLDGVLIYNDPYG VVLIIGAWNYPLQLALLPMAGAIAAGNTVILKPSEVSPASAQLIAKLLPK YLD----QECFQVVLGGVPETTQLLKEKFDYIFYTGSTEVGKIVRHAANE HLTPVTLELG----------------------------------GKS--- ---------------PVYLDNTADLEMAVKRIMWGKCINAGQTCIAPDYL LCSKQVEKEFVSKAKTILKEWYGDKSKESPDLCRIVTDRHYQRLVGLLKA GTVAVGGETDASEKFISPTILVDVKPTDPVMQEEIFGPILPVVNVESAFD AIKFINSR------------------EEPLTLYVFTTDKKVRELILSQTR SGSTCINDTLMHF------------------------------------- ------------------------------------------------KP LAFYIFSKSSKDRDLLINNVSCGGVCCNDTIMHLAVDTLPFGGVGNSGIG SYHGKYSFDTFTHKKSCLVKDFNGIGEKLAA------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -xxxxxx------------------------------------------- -------------------------------------------------- ----x >Tbi xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxM-------- ------x------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------IQRAR NAFHSGRTKPVEFREKQLNQLLRLYEENVPEMLTALSTDLR--------- -----------------------------------------------KSK QESLMTEIEYMKNDLKNTIHNLREWAKPEKPPKGFVNMLDGVLIYNDPYG VVLIMGAWNYPLQLALLPMAGAIAAGNTVILKPSEVSPASAQLIAKLMPK YLD----QECFHVVLGGVPETTQLLKEKFDYIFYTGSTEVGKIVRRAANE HLTPVTLELG----------------------------------GKS--- ---------------PVYLDNTADLEMAVKRIMWGKCINAGQTCIAPDYL LCSKQVEKEFVSKAKTILKEWYGEKSKESPDLCRIVTDRHYQRLVGLLKG GTVAVGGETDASEKFISPTIIVDVKPTDPIMQEEIFGPILPVVNVESAFD AIKFINSR------------------EEPLTLYVFTTDKKVRELILSQTR SGSTCINDTLMHFVV----------------------------------x xxxLLGRPNRVxxxxxKQCTPxxxxxxxxVxxxxPLGNLGRxxxxxWEKP LAFYIFTKSSKDRDLLINNVSCGGVCCNDTIMHLTVDTLPFGGVGNSGIG SYHGKYSFDTFTHKKSCLVKDFNGLGEKLAA------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----- >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxQECFHVVLGGVPETTQLLKEKFDYIFYTGSTEVGKIVRRAANE HLTPVTLELG----------------------------------GKS--- ---------------PVYLDNTADLEMAVKRIMWGKCINAGQTCIAPDYL LCSKQVEKEFVSKAKTILKEWYGEKSKESPDLCRIVTDRHYQ-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----- >Tte -------------------------------------------------- -------------------------------------------------- -----------------------------------------M-------- ------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxx------------------------------------------- ------------------------------------------------xx xxxxxxxxxxx--------------------------------------- --------------------------------------------IIQRAR NAFHSGRTKPVEFREKQLNQLLRLYEENVPEMLTALSTDLR--------- -----------------------------------------------KSK QESLMTEIEYMKNDLKNTIHNLREWAKPEKPPKGFVNMLDGVLIYNDPYG VVLIMGAWNYPLQLALLPMAGAIAAGNTVILKPSEVSPASAQLIAKLMPK YLD----QECFHVVLGGVPETTQLLKEKFDYIFYTGSTEVGKIVRRAANE HLTPVTLELG----------------------------------GKS--- ---------------PVYLDNTADLEMAVKRIMWGKCINAGQTCIAPDYL LCSKQVEKEFVSKAKTILKEWYGEKSKESPDLCRIVTDRHYQRLVGLLKG GTVAVGGETDASEKFISPTIIVDVKPTDPIMQEEIFGPILPVVNVESAFD AIKFINSR------------------EEPLTLYVFTTDKKVRELILSQTR SGSTCINDTLMHF------------------------------------- ------------------------------------------------KP LAFYIFTKSSKDRDLLINNVSCGGVCCNDTIMHLTVDTLPFGGVGNSGIG SYHGKYSFDTFTHKKSCLVKDFNGLGEKLAA------------SRYPPYS EKKIAMLGFLLKKRTGVSLKYLPHLVMFGLGIAATFGFRAIAQ------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----x >Tms -------------------------------------------------- -------------------------------------------------- -----------------------------------------x-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxxxDIVQRAR NAFHSGRTKSVEFREKQLNQLLRLYEENVPEMLTALSSDLRxALAVTTLC VPHSDLGFDNQINLCRNRGLNPGLPAQKSDTLPLDRQTLCLKMPKGAKSK QESLMTEIEYMKNDLINTIHNLREWVKPEKPPKGFVNMLDGVLIYNDPYG VVLIIGAWNYPLQLALLPMAGAIAAGNTVILKPSEVSPASAQLIAKLLPK YLD----QECFQVVLGAVPETTQLLKEKFDYIFYTGSTEVGKIVRHAANE HLTPVTLELG----------------------------------GKS--- ---------------PVYLDNTADLEMAVKRIMWGKCINAGQTCIAPDYL LCSKQVEKEFVSKAKTILKEWYGDKSKESPDLCRIVTDRHYQRLVGLLKA GTVAVGGETDASEKFISPTILVDVKPTDPVMQEEIFGPILPVVNVESAFD AIKFINSR------------------EEPLTLYVFTTDKKVRELILSQTR SGSTCVNDTLMHF------------------------------------- ------------------------------------------------KP LAFYIFSKSAKDRDLLINNVSCGGVCCNDTIMHLAVETLPFGGVGNSGIG SYHGKYSFDTFTHKKSCLVKDFNRLGEKLAA------------SRYPPYS EKKIAMLGFLLKKRAGVSLKYL---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----