>Tms x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxxxxxDTSLVTLTNVAGAESSSSRGKAKSLGLDSNNPVAV MRLRLENDRLQSEVVELRKLVGTCRSGSEAEGECEDPMRMRSLELELQHA REALAALKADRKRLKAEKFDLLNQMKQLYGTLEDKEKELRDFIRNYEQRM RESEASLQQLSTEREERERERWSLLRHARDEAERSLSLAAQLEVKEQQIQ QLQEQLYE------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----TRRQLSNQGGGCLSDQESLASMSISVSRVNGSSGGLTTPTAGHAH SGLLSSHHGFSSGAGLQPGDRGSCSADSGVRGSSDRESGGATSGGGNLSD STTDGM-------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------TSRLLLQNxATTPKDCSPSLSPLNANTFSxT--- -------------------------------------------------- ------------------------------------------------FS S------------------------------------------------- KSVVCVRSVEQLSSPAMEVEPRRPSKSQTSRSSGGSRGGTWGSISRVFAR SRHRKAASPSSQD------------------------------------- ----------------------------------------------GDWS PLTEEGYAEKLRLLREAASVPMERWRAPTVLAWLEIALGMPQYGPRCAEN VKSGKVLLELSDVELEVGLGITHPMHRKKLRLAIEEHRHPSLVRYPCIAQ LGHTWVSSEWLPDLGLA--------------------------------- ----------------------------QYSENFATNMVDARMLDHLSKK ELEKFLGVTRKFHQASIVHGIHLLRMMKYD-------------------- --RQALAVRRHQCETLDADPLVWTNQRFIRWARNIDLSEYADNLKDSGVH GALVVLEPSFNGDTMATALGIPPSKNIIRRHLSTELEALVLPARYVIFCQ MEEYQAEVARAVNN-----xxxxxxMVAQIVAQIFYINHKIKFDLKCKLL VCSILYL------------------------------------------- SKKLNFVNSxxxxxxxxxxxxxxxxxxxxxxFxxxxxxxIEMVLIxxxKS xNGR >Tcm x------------------------------------------------- --------------------------xxxxxxxxxxxGRxxIxxxxxxxP VLDIxxxxxxxxxFxxxxxxxxETxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxGxxxxx----------------------- -------------------xxxxNVTxxxxxxxILINVAGLDTxLVTLTN VAGLDTTLVILTNVAGPDTPLGxxxxxxxxYTTLVILTNIAGLDTTLVIL TNVASPDTTLGTLTNIAGLDTTLVILTNVASPDTTLGTLTNIAGLDTTLV ILTNIAGLDTTQVILTNxxxxDTTxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxx-----DTTLGTLTNVAGAESSSSRGKAKSSGLDSNNPVAV MRLRLENDRLQSEVVELRKLVGTCRSGSEAEGECEDPMRVRSLELELQHA REALAALKADRKRLKAEKFDLLNQMKQLYGTLEDKEKELRDFIRNYEQRM RESEASLQQLSTEREERERERWSLLRHARDEAERSLSLAAQLEVKEQQIQ QLQEQLYE------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----TRRQLSNQGGGCLSDQESLASMSISVSRVNGSSGGLTTPTAGHAH SGLLSSHHGFSSGAGLQPGDRGSCSADSGVRGSSDRESGGATSGGGNLSD STTDGM-------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------TSRLLLQN-xTTPKDCSPSLSPLNANTFS----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------KSVEQLSSPAMEVEPRRPSKSQTSRSSGGSRGGTWGSISRVFAR SRHRKAASPSSQD------------------------------------- ----------------------------------------------GGWS PLTEEGYAEKLRLLREAASVPMERWRAPTVLAWLEIALGMPQYGPRCAEN VKSGKVLLELSDVELEVGLGITHPMHRKKLRLAIEEHRHPSLVRYPCIAQ LGHTWVSSEWLPDLGLA--------------------------------- ----------------------------QYSENFATNMVDARMLDHLSKK ELEKFLGVTRKFHQASIVHGIHLLRMMKYD-------------------- --RQALAVRRHQCETLDADPLVWTNQRFIRWARNIDLSEYADNLKDSGVH GALVVLEPSFNGDTMATALGIPPSKNIIRRHLSTELEALVLPARYVIFCQ MEEYQAEVARAVNNVKQIT------------------------------- -------------------------------------------------- -------------------------------------------------- ---R >Tbi -----------------------------------xxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxx----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------SSSRGKAKSLGLDSNNPVAV MRLRLENDRLQSEVVELRKLVGTCRSGSEAEGDCEDPMRVRSLELELQHA REALAALKADRKRLKAEKFDLLNQMKQLYGTLEDKEKELRDFIRNYEQRM RESEASLQQLSTEREERERERWSLLRHARDEAERSLSLAAQLEVKEQQIQ QLQEQLYE------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----TRRQLSNQGGGCLSDQESLASMSISVSRVNGSSGGLTTPTAGHAH SGLLSSHHGFSSGAGLQPGDRGSCSADSGVRGSSDRESGGATSGGGNLSD STTDGM-------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------TSRLLLQNxATTPKDCSPSLSPLNANTFS----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------KSVEQLSSPAMEVEPRRPSKSQTSRSSSGSRGGTWGSISRVFAR SRHRKAASPSSQD------------------------------------- ----------------------------------------------GGWS PLTEEGYAEKLRLLREAASVPMERWRAPTVLAWLEIALGMPQYGPRCAEN VKSGKVLLELSDVELEVGLGITHPMHRKKLRLAIEEHRHPSLVRYPCIAQ LGHTWVSSEWLPDLGLA--------------------------------- ----------------------------QYSENFATNMVDARMLDHLSKK ELEKFLGVTRKFHQASIVHGIHLLRMMKYD-------------------- --RQALAVRRHQCETLDADPLVWTNQRFIRWARNIDLSEYADNLKDSGVH GALVVLEPSFNGDTMATALGIPPSKNIIRRHLSTELEALVLPARYVIFCQ MEEYQAEVARAVNNVKQIT------------------------------- -------------------------------------------------- -------------------------------------------------- ---R >Tte xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--------------- ---------xxxxxxxxxxxxxxxxxx----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------SSSRGKAKSLGLDSNNPVAV MRLRLENDRLQSEVVELRKLVGTCRSGSEAEGDCEDPMRVQSLELELQHA REALAALKADRKRLKAEKFDLLNQMKQLYGTLEDKEKELRDFIRNYEQRM RESEASLQQLSTEREERERERWSLLRHARDEAERSLSLAAQLEVKEQQIQ QLQEQLYE------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----TRRQLSNQGGGCLSDQESLASMSISVSRVNGSSGGLTTPTAGHAH SGLLSSHHGFSSGAGLQPGDRGSCSADSGVRGSSDRESGGATSGGGNLSD STTDGM-------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------TSRLLLQNxATTPKDCSPSLSPLNANTFS----- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------KSVEQLSSPAMEVEPRRPSKSQTSRSSSGSRGGTWGSISRVFAR SRHRKAASPSSQD------------------------------------- ----------------------------------------------GGWS PLTEEGYAEKLRLLREAASVPMERWRAPTVLAWLEIALGMPQYGPRCAEN VKSGKVLLELSDVELEVGLGITHPMHRKKLRLAIEEHRHPSLVRYPCIAQ LGHTWVSSEWLPDLGLA--------------------------------- ----------------------------QYSENFATNMVDARMLDHLSKK ELEKFLGVTRKFHQASIVHGIHLLRMMKYD-------------------- --RQALAVRRHQCETLDADPLVWTNQRFIRWARNIDLSEYADNLKDSGVH GALVVLEPSFNGDTMATALGIPPSKNIIRRHLSTELEALVLPARYVIFCQ MEEYQAEVARAVNNVKQIT------------------------------- -------------------------------------------------- -------------------------------------------------- ---R >Tce x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------xxxxxxDTTLVTLTNVAGAESSSSRGKAKSLGLDSNNPVAV MRLRLENDRLQSEVVELRKLVGTCRSGSEAEGECEDPMRMRSLELELQHA REALAALKADRKRLKAEKFDLLNQMKQLYGTLEDKEKELRDFIRNYEQRM RESEASLQQLSTEREERERERWSLLRHARDEAERSLSLAAQLEVKEQQIQ QLQEQL-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------HHGFSSGAGLQPGDRGSCSADSGVRGSSDRESGGA--------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------x xxxxxxxxxxxxxxxxxxWxxxxxxxxxxxxxxxxxxxxxxxxxxxNRQH KSVVCVRSVEQLSSPAMEVEPRRPSKSQTSRSSGGSRGGTWGSISRVFAR SRHRKAASPSSQD------------------------------------- ----------------------------------------------GDWS PLTEEGYAEKLRLLREAASVPMERWRAPTVLAWLEIALGMPQYGPRCAEN VKSGKVLLELSDVELEVGLGITHPMHRKKLRLAIEEHRHPSLVRYPCIAQ LGHTWVSSEWLPDLGLA--------------------------------- ----------------------------QYSENFATNMVDARMLDHLSKK ELEKFLGVTRKFHQASIVHGIHLLRMMKYD-------------------- --RQALAVRRHQCETLDADPLVWTNQRFIRWARNIDLSEYADNLKDSGVH GALVVLEPSFNGDTMATALGIPPSKNIIRRHLSTELEALVLPARYVIFCQ MEEYQAEVARAVNN-----xxxxxxM----VAQIFYINHKIKFDLKYKLL VCSILYLVSSSNNVIExxxxxxxxxxxxxHxxxxxxxISIINRDxxxxxD Sx------------------------------------------------ ---Y >Tsi x------------------------------------------------- ----------------------x--------------------------- -------------------------------------------------- -------------------------xxVLxxxxxxTTKSFQKLPDQIMYP YxxxxxxxxxxxxxxxxxxxxxxNxxGLDTTLVxxxxxxxxxxxxxTLTN VAGLDTTLVILTNVAGPDTPLGxxxxxxxxYTTLVILTNIAGLDTTLEIL TNVASPDTTLGTLTNIAGLDTTLVILTNVASPDTTLRT------------ -LTNIAGLDTTQVILTNVASPDxxxxxxxxxxxxxxxxxxxxxxx----- -------------xxDTTLGTLTNVAGAESSSSRGKAKSSGLDSNNPVAV MRLRLENDRLQSEVVELRKLVGTCRSGSEAEGECEDPMRVRSLELELQHA REALAALKADRKRLKAEKFDLLNQMKQLYGTLEDKEKELRDFIRNYEQRM RESEASLQQLSTEREERERERWSLLRHARDEAERSLSLAAQLEVKEQQIQ QLQEQLYEFSVTLQRCQFSLTLQRCQFSVTLQRCQFSLTLATLPDLSDPA ILPRCQFSLTLKRCQFSLTLQHCQLSLTLKCCQFSVTLQLFIDPATLPVI IDPATLPVLSDLATLPFLIDSATLPVIIDPAMLPVLSDLATLPVLIDSAT LPVLFDPATLTVLFDPATLPVLFDPAMLPVFIDPATLPVLSDLAMLPVLF DPTTLPVLTDPATLPVLIDPTMLPVLINPAMLTVLFDPTMLPGLINPAML TVLFDPAMLPGLSDLATLPVLLDPTTLPVLSDPATLTVLFDPAMLPVLTD PAMLPTRRQLSNQGGGCLSDQESLASMSISVSRVNGSSGGLTTPTAGHAH SGLLSSHHGFSSGAGLQPGDRGSCSADSGVRGSSDRESGGATSGGGNLSD STTDGAxxxxVxFVPYHPQHRVLVVYKSPIHMCEPFPSSVERPPLPxxxx xxxxxxSNGRPLILLPFKKGRDISASTIAVEGNNVDMDTISVVSSIAAPH MYQLLTSHKSLGDYIVVSDGPGPTVAALGLEMFLPTSVEARHILAVVTYG KMLSLVILIYPxxxxxx--------ATTPKDCSPSLSPLNANTFSKSIDN SVLSRLKRWVTTAFDLLTIEAGDSYSRDCPKNQGLNDHLNPKLIIGSVID FDPALVKTFTVLFAGLNLDLIHTLVTSPPDRASVVVAWLGSSAxxxxxFD S------------------------------------------------- GRVVPIRSVEQLSSPAMEVEPRRPSKSQTSRSSGGSRGGTWGSISRVFAR SRHRKAASPSSQDxxxxxxxVCLPPxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---- -------------------------------------------------- -----VLLELSDVELEVGLGITHPMHRKKLRLAIEEHRHPSLVRYPCIAQ LGHTWVSSEWLPDLGLAQGNEKHRNLRQSHPEKAFNSPPFPSYPYHHHYR GSRGTLACQSNNDNFFERLRLIYLRLTLQYSENFATNMVDARMLDHLSKK ELEKFLGVTRKFHQASIVHGIHLLRMMKYDxxSKFRTNTINTNIIYNPLT CLRQALAVRRHQCETLDADPLVWTNQRFIRWARNIDLSEYADNLKDSGVH GALVVLEPSFNGDTMATALGIPPSKNIIRRHLSTELEALVLPARYVIFCQ MEEYQAEVARAVNNVKQIT------------------------------- -------------------------------------------------- -------------------------------------------------- ---R