>Tge ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------MAEEQLDQALSQVCKHFDADHYSKVHSAYKLLGKMQMAMDQMHMHFASA IHNSAFNVVHGYVELCFVQTHGEDPVILHKKQFRELCKFVTAESFIPCLLDLCKALWEIM KSYHKVIIWQQRNDSDKLTAD--------------------------------------- ----------------------------------GAMENVDFEASFNKEYVKQKLENGLA RIWQDVQSRISVYLLGSDLAWYKFDEFLQVLGIVHRLMEVGEEFCGSKSTDLQNSIRTQS MNYFINYHQSRLDELRIFLENEGWEICPVKPNFTILRLQEFGSLRHILKYWKN-DLSSQG HLNMSSPECSSNHSQDDSSLSGGYFARYSDSGSPFDISQDEVQEEDILANIGLQDEPSGY FSDESDEDIPEELTKDFVDENMGDTVSNK------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---HSKPTSKKNIHVELLKAPILTNTALTVLRQCGKYLQMSHLLRPIACDVITCMSQLFE YYLYTVYSFFANDLPVSCHSMFSLKLQATLKRIKDKLILSDQDQEQKPSEINKRKILPPQ MSTGVEMNQAESLYGLAERVVAVESLVFLAKQFKFLQSYLEHLIPHNSPVTGNSAPLHHF YSQTILVATELRRPVYMNVCARAVDFNTTLNSMAKVNWEVKEVMSQHSQYVDNLL----- RDLQIFSMRLEEVSCRVPLSPDILNILWENVAYLCCNTFVEGSY--------QDGVQQDD GWKEVIERNLKSLKSNKARELVYPAPGVSIIESRWV---FTEKMIEGVTHKETCLVAK-- ------------SYQQPPLEEEDLFHDGPMLFWDTFKNTELQIEEEQLFAEGAED >Tbi ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------MQMAMDQMHMHFASA IHNSAFNVVHGYVELCFVQTHGEDPVILHKKQFRELCKFVTAESFIPCLLDLCKALWEIM KSYHKVIIWQQRNDSDKLTAD--------------------------------------- ----------------------------------GAMENVDFEASFNKEYVKQKLENGLA RIWQDVQSRISVYLLGSDLAWYKFDEFLQVLGIVHRLMEVGEEFCGSKSTDLQNSIRTQS MNYFINYHQSRLDELRIFLENEGWEICPVKPNFTILRLQEFGSLRHILKYWKN-DLSSQG QLNMSSPECSSNHSQDDSSLSGGYFARYSDSGSPFDISQDEVQEEDILANIGLQDEPSGY FSDESDEDIPEELTKDFVDENMGDTASNK------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---HSKPTSKKNIHVELLKAPILTNTALTVLRQCGKYLQMSHLLRPIACDVITCMSQLFE YYLYTVYSFFANDLPVSCHSMFNLKLQATLKRIKDKLILSDQDQEQKPSEINKRK----- ------------------------------------------------------------ ---TILVATELRRPVYMNVCARAVDFNTTLNSMAKVNWEVKEVMSQHSQYVDNLL----- RDLQIFSMRLEEVSCRVPLSPDILNILWENVAYLCCNTFVEG------------------ ------------------------------------------------------------ ------------------------------------------------------- >Tte ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------QN-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LFLN-------------- -----------NYL---------------------------------------------- ----------------------QVCKHFDADHYSKVYSAYKLLGKMQMAMDQMHMHFASA IHNSAFNVVHGYVELCFVQTHGEDPVILHKKQFRELCKFVTAESFIPCLLDLCKALWEIM KSYHKVIIWQQRNDSDKLTADMKLRKTVWTHLVWSLLTGLLHDSENTRTPQHIMYPTNSP WLEIQLRARLEHVNIEMRRPICASDCVLVFVNGNGAMENVDFEASFNKEYVKQKLENGLA RIWQDVQSRISVYLLGSDLAWYKFDEFLQVLGIVHRLMEVGEEFCGSKSTDLQNSIRTQS MNYFINYHQSRLDELRIFLENEGWEICPVKPNFTILRLQEFGSLRHILKYWKN-DLSSQG QLNMSSPECSSNHSQDDSSLSGGYFARYSDSGSPFDISQDEVQEEDILANIGLQDEPSGY FSDESDEDIPEELTKDFVDENMGDTASNK------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---HSKPTSKKNIHVELLKAPILTNTALTVLRQCGKYLQMSHLLRPIACDVITCMSQLFE YYLYTVYSFFANDLPVSCHSMFNLKLQATLKRIKDKLILSDQDQEQKPSEINKRKILPPQ MSTGVELNQAESLYGLAERVVAVESLVFLAKQFKFLQSYLEHLIPHNSPVTGNSAPLHHF YSQTILVATELRRPVYMNVCARAVDFNTTLNSMAKVNWEVKEVMSQHSQYVDNLL----- RDLQIFSMRLEEVSCRVPLSPDILNILWENVAYLCCNTFVEGG----------SGIIPLD -WQAVLSKIPIMLEPTSAG--TNGNTNSLVTQTRWAD-ALLGYLQEHRTPNRGGTTRRGR GRRQNVVPGRTITFQSIRLSESST--DRPVATTSSGPRSARRSSKKKNRTQSSEE >Tpa ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------MENVDFEASFNKEYVKQKLENGLA RIWQDVQSRISVYLLGSDLAWYKFDEFLQVLGIVHRLMEVGEEFCGSKSTDLQNSIRTQS MNYFINYHQSRLDELRIFLENEGWEICPVKPNFTILRLQVCRNIPFIVNY---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------- >Tce M-------DELK------------------------------------------------ ---------------HKF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------LDL--- ---------------------------------------------LNKKGHYSQQPLSSP KLELVVNTSQDDQISIVKESQNNALKQTEVEPLADQEILESIEQHYFSDSNFDPCEHVLR EVPEILDCASIEAESEKIQKQLQV----------------------------VSNNVLRL ILHKQ------------------------------------------------------- ----------SICNDEFE--RILEIQKELQSTLKICQVGRSHLFLAKRQFTTASLGILAN YRKRQVVQGLLHYLQTIKTLQRTDERLQELLNEGDYPSAIRLLLECQNAAATYKHFTCVA ALSGKLQDTLEMAEEQLDQALSQVCKHFDADHYSKVHSAYKLLGKMQMAMDQMHMHFASA IHNSAFNVVHGYVELCFVQTHGEDTVVLHKKQFRELCKFVTAESFIPCLIDLCKALWEIM KSYHKVIIWQQRNDSDKLTAD--------------------------------------- ----------------------------------GAMEKVDFEASFNKEYVKQKLENGLA RIWQDVQSRISVYLLGSDLAWYKFDEFLQVLGIVHRLMEVGEEFCGSKSIDLQNSIRTQS MNYFINYHQSRLDELRIFLENEGWEICPVKPNFTILRLQEFGSLCHILKYWKNIDLSSQG QLNMSSPECSSNHSQDDSSLSGGYFARYSDSGSPFDISQDEVQEEDILANIGLQDEPSGY FSDESDEDIPEELTKDFVDENMGDTVSNK------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---HSKPTCKKNVHVELLKAPILTNTALTVLRQCGKYLQMSHLLRPIACDVITCMSQLFE YYLYTVYSFFANDLPVSCNSMFSLKLQATLKRIKDKLILSDQDQEQKPSEINKRKILPPQ MSTGVELNQAESLYGLAERVVAVESLVFLAKQFKFLQSYLEHLIPHNSPVTGNSAPLHQF YSQTILVATELRRPVYMHVCARAVDFNTTLNSMAKVNWEVKEVMSQHSQYVDNLLRTKLN RDKQIRTVPLVEWFCEDNMCLHVMEL---------CSM---------------APLPPLM SYLAPIGRLLGIVE-----------------------TALEFYMFRHIY---GAII---- ---------RTFDFA---------------------------------------- >Tms MKSETFHSDEKRENHGKLSEYRCYRFRECCYNRLRFASVSAAQLLQRKLIGYFVPSLGRV NRDDTGKYQDIFYTNHAFTCVVDLDQDVDDNYQFFTLSVSRLRFEGGARSKRDVIAIKQG HKKGGRIEGREGWRTLQTRGEEKFETHIEHVAPSRSSAKAETELFYPLSLLAEHVVELRC RQARTRLQSVRCIWRERRSPVKLVPRVDPVGCPSWRVLLQCKSLHRYPSWLSELSGGGIK NMEFTSGMLHAARQANSKRREAIEEMKKKESEEANRSKTTLETAEEEAPALQTEIDLEKK RLRQIKASDSSPTAISTDVMEPNINIGMDFQSTFEVSIHCELGSEIYKSGHYSQQPLSSP KLELVVNTSQDDQISIVKESQNNALKQTEVEPLADQEILESIEQHYFSDSNFDPCEHVLR EVPEILDCASIEAESEKIQKQLQVYTCLAWSTQKTQRLRNSRPSEPMQDCIKVPGDILSK ESHEQEGLSPNRNHHPTESIHHAQHRHQSPGWILLQMDKTKRHLRPVYTTPAPTSRNAEL VKIYQLQPRPSQDKDDHETVKILEIQKELQSTLKICQVGRSHLFLAKRQFTTASLGILAN YRKRQVVQGLLHYLQTIKTLQRTDERLQELLNEGDYPSAIRLLLECQNAAATYKHFTCVA ALSGKLQDTLEMAEEQLDQALSQVCKHFDADHYSKVHSAYKLLGKMQMAMDQMHMHFASA IHNSAFNVVHGYVELCFVQTHGEDTVVLHKKQFRELCKFVTAESFIPCLIDLCKALWEIM KSYHKVIIWQQRNDSDKLTAD--------------------------------------- ----------------------------------GAMEKVDFEASFNKEYVKQKLENGLA RIWQDVQSRISVYLLGSDLAWYKFDEFLQVLGIVHRLMEVGEEFCGSKSIDLQNSIRTQS MNYFINYHQSRLDELRIFLENEGWEICPVKPNFTILRLQGI------------------- ------PVSGIATKERLEQLLRGGMAQTGKGGRN--------EQEN------LQDEPSGY FSDESDEDIPEELTKDFVDENMGDTVSNNRPSYLSFALAPAAPTTLPTAWTGPQSLFSEP SVTTPPQYPAPALAIGSREGQTLSHVFPHQWEAPVFPIGQGQAAVEEHCHRYSLTFRNYP LPLIATHVAGTVPLPPTATHVAGTVPLPPTATHVAGTVPLPSTVAHVAGTVPLPPTATHV VGTVPLPPTATYVVGTVPLPPTATYVAGTVPLPPTATHVAGTVPLSPTVTPCCQDSVLSP SNLIVPSDEMGCTRRAGKAHRQKTLKKTVTTKQYSTRGPLFYDPDCNHQTPERQHSAPAS PRVPVPELANSFPRLPLTPTIRPPPTPISPFSPKGYHLHTLATPEPAYVFSPISLPYPHP LDPHSKPTCKKNVHVELLKAPILTNTALTVLRQCGKYLQMSHLLRPIACDVITCMSQLFE YYLYTVYSFFANDL-----------------------------------------ILPPQ MSTGVELNQAESLYGLAERVVAVESLVFLAKQFKFLQSYLEHLIPHNSPVTGNSAPLHQF YSQTILVATELRRPVYMHVCARAVDFNTTLNSMAKVNWEVKEVMSQHSQYVDNLL----- RDLQIFSMRLEEVSCRVPLSLDILNILWENVAYLCCNTFVEGFSNAKKCSNGGRALMQLD -FTQFLSKFEKLTSIKPIP--NREFVEAYVKAYYQPDTELEAWIKEHSEYSTKQLLALVN CSCHNNKKARQHLFS--LLEE----------------------------LEKVNR