>Tge -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------xxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------QLGCNSQFSLSLAEGLVKDYFVLVPKAVSGLQDLP QLAPHFTANFLTSVAEMYSSGDKRQVLTPPPNTLLEVVTQWVSDNPPLCL AALLNKTATAVTTPFVGLFKWCILSPLYYCGRTSSTEHSTLYSRLHLALL ESLVRCGKPLAANGKTVISVQHVVSIVDPLIRWYKEVDKLPDGSKAVELA LDRLAQAVQIGLFTGCIAGDKEELLKMLDMLPEHRVLKLVIKKQRELLTQ NMDILEDDVIIVSDTSQTRMVIMSPDLPR--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------- >Tbi x------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx xxxxxxxxxxxxxxxKTEKLGCIQELQLLEALCDFFKPSYTSGNSDTTRN SVFMALFPPSVAERSRLLVKLVSMAISTKNVPVLAATGIWMQGGKQERKQ --------------------------GKxxxKQRRQxxxxxxxxxxxxxx xxRGSKxx----xxxxxxxRxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx EDREENRRGSKEDRExNRRGSKxDRExNRxxxxEDRExxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxRRGSKxxxxxxxxGSEEDREENRRGSxx DREENRRGSEEDxxxxxxxxxxDRE-------xxxxxxxxxxxxxxxENR RGSExxxxxxxxxxxxxxxxxxxxxxEDRxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxx----RxxxKED----RRGSKED----Rxxxxxxxxxxxx xxxxx----xxxxxxxx--------------------------------- ------------------------------------------------xx xxxxxxxx------xxxxxNSQFSLNLAEGLVKDYFVLVPKAVSGLQDLP QLAPHFTANFLTSVAEMYTSGDKRQVLTPPPNTLLEVVTQWVSDNPPLCL AALLNKTATAVTTPFVGLFKWCILSPLYYCGRTSSTEHSTLYSRLHLALL ESLVRCGKPLAANGKTVISVQHVVSIVDPLIRWYKEVDKLPDGSKAVELA LDRLAQAVQIGLFTGCIAGDKEELLKMLDMLPEHRVLKLVIKKQRELLTQ NMDILEDDVIIVSDTSQSRMVIMSPDLPRIS------------------- ---------------------------------CExxxxxxxxxxxxxxx xxxxxxxxxxxxxxLGGVTHxxxx-------------------------- ------------------------------------------------xx xxxxxxxAIxKQGxxxxAxxETQxxxISLVLGLQxKVLAIKHLEKDRNTV TRLEAVCAVASxVKWTP-------x >Tpa x------------------------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxFVxxxxxxxxxRRR- ------------------KLGCIQELQLLEALCDFFKPSYTSGNSDTTRN LVFMALFPPSVAERSRLLVKLVSMAISTKNVPVLAATGxxxxxDK----- ------------------------------------------------EE NRRGSxxxREENRxxxxxxxxxxxxxSKExxExxxxxxxxxREENxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxDRExxxxxxxxDRExxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxKEDxxxxx xxxxxxxxxNRRGSKxxxxxxxxxxxxxxxENRRGSKxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxSxxxxxxxxxxxxxxxxxxxxxxxxx------------ -----------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx- ------------------------LSLAEGLVKDYFVLVPKAVSGLQDLP QLAPHFTANFLTSVAEMYSSGDKRQVLTPPPNTLLEVVTQWVSDNPPLCL AALLNKTATAVTTPFVGLFKWCILSPLYYCGRTSSTEHSTLYSRLHLALL ESLVRCGKPLAANGKTVISVQHVVSIVDPLIRWYKEVDKLPDGSKAVELA LDRLAQAVQIGLFTGCIAGDKEELLKMLDMLPEHRVLKLVIKKQRELLTQ NMDILEDDVIIVSDTSQTRMVIMSPDLPRLSKYxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxRxxxxxxxxxxxx---------------- -------------------------------------------------- -------------------------------------------------- EVRENTFVSRKQGVFIAAGGETN--------------------------- -------------SWKPYVSCLVYK >Tsi xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------------- -------------------------------------------------- -xxxxxxxxxxxxxxxTKPHHHSTNMELAKDLMAxFVxCEIDRRGGRRR- ------------------KLGCIQELQLLEALCDFFKPSYTSGNSDTTRN LVFMALFPPSLAERSRLLVKLVSMAISTKNVPVLAATG------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------IWMQQLGCNSQFSLNLAEGLVKDYFVLVPKAVSGLQDLP QLAPHFTANFLTSVAEMYSSGDKRQVLNPPPNTLLEVVTQWVSDNPPLCL AALLNKMATAVTTPFVGLFKWCILSPLYYCGRTSSTEHSTLYSRLHLALL ESLVRCGKPLAANGKTVISVQHVVSIVDPLIRWYKEVEKLPDGSKAVELA LDRLAQAVQIGLFTGCIAGDKEELLKMLDTLPEHRVLKLVIKKQRELLTQ NMDILEDDVIIVSDTSQTRMVIMSPDLPR--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------- >Tps x-----------------------------------xxxxxxxxxxxxxx xxxxxxxxxxxxx------------------------------------- xxxxxxxxxxxxxxxxTKPHHHSTNMELAKDLMAxFVxCEIDRRGGRRR- ------------------KLGCIQELQLLEALCDFFKPSYTSGNSDTTRN LVFMALFPPSLAERSRLLVKLVSMAISTKNVPVLAATG------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------IWMQQLGCNSQFSLNLAEGLVKDYFVLVPKAVSGLQDLP QLAPHFTANFLTSVAEMYSSGDKRQVLNPPPNTLLEVVTQWVSDNPPLCL AALLNKMATAVTTPFVGLFKWCILSPLYYCGRTSSTEHSTLYSRLHLALL ESLVRCGKPLAANGKTVISVQHVVSIVDPLIRWYKEVEKLPDGSKAVELA LDRLAQAVQIGLFTGCIAGDKEELLKMLDTLPEHRVLKLVIKKQRELLTQ NMDILEDDVIIVSDTSQTRMVIMSPDLPR--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------- >Tdi x-----------------------------------xxxxxxxxxxxxxx xxxxxxxxxxxxx------------------------------------- xxxxxxxxxxxxxxxxTKPHHHSTNMELAKDLMAxFVxCEIDRRGGRRR- ------------------KLGCIQELQLLEALCDFFKPSYTSGNSDTTRN LVFMALFPPSLAERSRLLVKLVSMAISTKNVPVLAATG------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------IWMQQLGCNSQFSLNLAEGLVKDYFVLVPKAVSGLQDLP QLAPHFTANFLTSVAEMYSSGDKRQVLNPPPNTLLEVVTQWVSDNPPLCL AALLNKMATAVTTPFVGLFKWCILSPLYYCGRTSSTEHSTLYSRLHLALL ESLVRCGKPLAANGKTVISVQHVVSIVDPLIRWYKEVEKLPDGSKAVELA LDRLAQAVQIGLFTGCIAGDKEELLKMLDTLPEHRVLKLVIKKQRELLTQ NMDILEDDVIIVSDTSQTRMVIMSPDLPR--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------- >Tcm -------------------------------------------------- ------------NxxxxxxxxxxxxxxxxxxxxxxxxxxxPFCAREALxx xxxxxxxxxxxxxxxxTKPHHHSTNMELAKDLMAxFVxCEIDRRGGRRR- ------------------KLGCIQELQLLEALCDFFKPSYTSGNSDTTRN LVFMALFPPSLAERSRLLVKLVSMAISTKNVPVLAATG------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------IWMQQLGCNSQFSLNLAEGLVKDYFVLVPKAVSGLQDLP QLAPHFTANFLTSVAEMYSSGDKRQVLNPPPNTLLEVVTQWVSDNPPLCL AALLNKLATAVTTPFVGLFKWCILSPLYYCGRTSSTEHSTLYSRLHLALL ESLVRCGKPLAANGKTVISVQHVVSIVDPLIRWYKEVEKLPDGSKAVELA LDRLAQAVQIGLFTGCIAGDKEELLKMLDTLPEHRVLKLVIKKQRELLTQ NMDILEDDVIIVSDTSQTRMVIMSPDLPR--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------- >Tte x------------------------------------------------- ------------------------xxxxxxxxxxLRKxxxPFCAREALxx xxxxxxxxxxxxxxxxSKPHHHSTNMELAKDLMAxFVxCEIDRRGGRRR- ------------------KLGCIQELQLLEALCDFFKPSYTSGNSDTTRN SVFMALFPPSVAERSRLLVKLVSMAISTKNVPVLAATGx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-- --xxxxxxx----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxx----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxx------------------------------- -------xxxx-------------LNLAEGLVKDYFVLVPKAVSGLQDLP QLAPHFTANFLTSVAEMYTSGDKRQVLTPPPNTLLEVVTQWVSDNPPLCL AALLNKTATAVTTPFVGLFKWCILSPLYYCGRTSSTEHSTLYSRLHLALL ESLVRCGKPLAANGKTVISVQHVVSIVDPLIRWYKEVDKLPDGSKAVELA LDRLAQAVQIGLFTGCIAGDKEELLKMLDMLPEHRVLKLVIKKQRELLTQ NMDILEDDVIIVSDTSQSRMVIMSPDLPRLA------------------- -------------------------------------------------- -----------------------SQxxxxxDKxxxxxxxxxxxxxxxxxx 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