>Tge -----------------------------------------x-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------xxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxDESVMH PLLNDVPTRTSRSVRGEQ-------------------------------- ---------------------------DxxxWTNSGQEELYCSVPPYLVL QTLANWxxxASYWTNSGQEELWRHATQQPILVRAKNVILFLGDGMSIPTL AATRAYLGQRSGQTGEEVSLSFERFPYTGLSKTYCVDRQVADSACSSTAY FCGVKNNYGTLGVSATVTRRDCQAMRNSSNHVDSILVWA----------- ------------------------------------QDAGKSTGLVTTTR ITHASPAGGYSHTAERNWESDADVASNNADPHQCADIAKQLVRNSPGKNV K------V---------xxxxQGxxxxRFIRDKGKIIVSSGALExxxxKV IVSSGAHExxxxK-----GSV---WGTQVVLGGGRRAFRPNTVKDEEGKR GVRIDGADLVDEWKRDKLRRGASNSYVWDRDGLLGVNTDTTEYLL----- ------GLFDHNHMQYHLDADPTTEPTLPEMTATAIKMLQKDKAGYFLFV E--------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx TxxxxxxxxxxxxxxxxxxxxxESVDTTEQPESVDTTEQPESVDTTEQPE SVDATEQPxxxxxxxxxxxLEVRVRKHLEKQxxxxxxxxLAPSRxxxPDx xxxxxxL--------------RGRxDHAHHGTSAxKALDETVQFHEAVRV AAELTEEKDTLIVVTSDHAHVMSYSGYPTRGNDILxETVTVTLCAVETAI VTLCAVETVIVTLCAVETLTVVL--------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------CAVETV IVVLCAVDTVIVTLCAVETVIVVLYAGVAGNSVVDRLPYSTISYGxxxxx xxxxxxxxxYDISRDNTRDKNYMFPALLPLNSETHGGDDVGVFARGPxAH LFTGVYEQHVIPHMMAFASCIGRGLTACWAR------------------- ---- >Tms -----------------------------------------MPYYWGKGG GGIQHEDRDVYPDKLAELCLQNQxxxxxxxxxxxxxxxxxxxxxxFRDRR GDIVTxxxxxRxxxxCSETG----------------------GDIVTVQx xxxxxxxxxxxxxxxxxxxxDxRGDIVTVQRxxxxxxxxxxxxGEILSLF RDxxxxxxxxxxxxxxxxxxxxxxGEILSLF------------------- ------------------------RxxxxxxxxxxxxxRDIVTCCxxxxx xxxxxxxTxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--- -----------------------------------------xxxDESVMH PLLDDVATRTSRSVRGEQ-------------------------------- ---------------------------D---------------------- ---------ASYWTTNAQEQLWRHATQQPILGRAKNVILFLGDGMSIPTL AATRAYLGQRSGQTGEEVSLSFEQFPYTGLSKTYCVDRQVADSACTSTAY FCGVKNNYGTLGVSAAVTRRDCQAMRNSSNHVDSILAWAxVCNHADSTRG LEPIKEAITMVYSCTVLVGGRLGRYWISLVHGVTVWQDAGKSTGLVTTTR ITHASPAGGYSHTAERNWESDADVASNNADPHQCADIAKQLVRNSPGKNV Kxxxxxxx------------------------------------------ ------------xxxxxxGSV---WGTQVVLGGGRRAFRPNTVKDEEGKR GVRIDGVDLVDEWKRDKLRRGASNSFAWDRNGLLGVNTDTTEYLL----- ------GLFDPNHMQYHLDADPTTEPTLPEMTATAIKMLQKDKAGFFLFV ExxxxxxTTxxxxxxx---------------------------------- -------------------------------------------------- ---------xxxxxxxx--------------------------------- ------xxxxxxxxxx--xSSGGRxDHAHHGTSAxKALDETVQFHEAVRV AAELTDEKDTLIVVTSDHAHVMSYSGYPTRGNDIL--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------GIAGNSIVDRLPYSTISYGNGPxx xxxxxxxxxYDISRDNTKDKNYMFPALLPLNSETHGGDDVGVFARGPxAH LFTGVYEQHVIPHMMAFASCIGRGLTACWAR------------------- ---- >Tte -----------------------------------------x-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xxxx-xxxxxxxxxxxxxx---------- --------------------------------------------DESVMH PLLNDVPTRTSRSVRGEQ-------------------------------- ---------------------------D---------------------- ---------ASYWTNSGQEELWRHATQQPILGRAKNVILFLGDGMSIPTL AATRAYLGQRSGQTGEEVSLSFEQFPYTGLSKTYCVDRQVADSACSSTAY FCGVKNNYGTLGVSATVTRRDCQAMRNSSNHVDSILVWA----------- ------------------------------------QDAGKSTGLVTTTR ITHASPAGGYSHTADRNWESDADVASNNADPHQCADIAKQLVRNSPGKNV K------------------------------------------------- ------------------GSV---WGTQVVLGGGRRAFRPNTVKDEEEQR GVRIDGADLVDEWKRNKLRRGASNSYVWDRDGLLGVNTDTTEYLL----- ------GLFDHNHMQYHLDADPTTEPTLPEMTATAIKMLQKDKAGYFLFV E------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------GGRxDHAHHGTSAxKALDETVQFHEAVRV AAELTEEKDTLIVVTSDHAHVMSYSGYPTRGNDIL--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------GVAGNSIVDRLPYSTISYGxxxxx xxxxxxxxxYDISRDNTRDKNYMFPALLPLNSETHGGDDVGVFARGPxAH LFTGVYEQHVIPHMMAFASCIGRGLTACWAR------------------- ---- >Tps xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------DESVMH PLLNDVPTRTSRSVRDEQ-------------------------------- ---------------------------D---------------------- ---------ARYWTTSGQEELWRHATQQPILGRAKNVILFLGDGMSIPTL AAARAYLGQRSGQTGEEVSLSFEQFPYTGLSKTYCVDRQVADSACTSTAY FCGVKNNYGTLGVSAAVARRDCQAMRNTSNHVDSILAWA----------- ------------------------------------QDAGKSTGLVTTTR ITHASPAGGYSHTAERNWESDADVASNNADPHQCADIAKQLVRNSPGKNV K------------------------------------------------- ----------------------------VVLGGGRRAFRPNTVKDEEGKR GVRIDGVDLVDEWKRDKLRRGASSSYAWDRDGLLGVNTDTTEYLL----- ------GLFDDNHMQYHLDADPTTEPTLPEMTATAVKMLQKDKAGYFLFV E------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------GGRxDHGHHGTSAxKALDETVQFHEAVRV AAELTDEKDTLIVVTSDHAHVMSYSGYPTRGNDIL--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------GIAGNSIVDRLPYSTISYGNGPxx xxxxxxxxxYDISRDNTKDKNYMFPALLPLNSETHGGDDVGVFARGPxAH LFTGVYEQHVIPHMMAFASCIGRGLTACWAR------------------- ---- >Tdi -xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------DESVMH PLLNDVPTRTSRSVRDEQ-------------------------------- ---------------------------D---------------------- ---------ARYWTTSGQEELWRHATQQPILGRAKNVILFLGDGMSIPTL AAARAYLGQRSGQTGEEVSLSFEQFPYTGLSKTYCVDRQVADSACTSTAY FCGVKNNYGTLGVSAAVARRDCQAMRNTSNHVDSILAWA----------- ------------------------------------QDAGKSTGLVTTTR ITHASPAGGYSHTAERNWESDADVASNNADPHQCADIAKQLVRNSPGKNV K------------------------------------------------- ----------------------------VVLGGGRRAFRPNTVKDEEGKR GVRIDGVDLVDEWKRDKLRRGASSSYAWDRDGLLGVNTDTTEYLL----- ------GLFDDNHMQYHLDADPTTEPTLPEMTATAVKMLQKDKAGYFLFV E------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------GGRxDHGHHGTSAxKALDETVQFHEAVRV AAELTDEKDTLIVVTSDHAHVMSYSGYPTRGNDIL--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------GIAGNSIVDRLPYSTISYGNGPxx xxxxxxxxxYDISRDNTKDKNYMFPALLPLNSETHGGDDVGVFARGPxAH LFTGVYEQHVIPHMMAFASCIGRGLTACWAR------------------- ---- >Tpa xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------DESVMH PLLNDVPTRTSRSVRGEQ-------------------------------- ---------------------------D---------------------- ---------ASYWTNSGQEELWRHATQQPILGRAKNVILFLGDGMSIPTL AATRAYLGQRSGQTGEEVSLSFERFPYTGLSKTYCVDRQVADSACSSTAY FCGVKNNYGTLGVSATVTRRDCQAMRNSSNHVDSILVWA----------- ------------------------------------QDAGKSTGLVTTTR ITHASPAGGYSHTAERNWESDADVASNNADPHQCADIAKQLVRNSPGKNV K------------------------------------------------- ----------------------------VVLGGGRRAFRPNTVKDEEGKR GVRIDGADLVDEWKRDKLRRGASNSYVWDRDGLLGVNTDTTEYLL----- ------GLFDHNHMQYHLDADPTTEPTLPEMTATAIKMLQKDKAGYFLFV E------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------GGRxDHAHHGTSAxKALDETVQFHEAVRV AAELTEEKDTLIVVTSDHAHVMSYSGYPTRGNDIL--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------GVAGNSVVDRLPYSTISYGxxxxx xxxxxxxxxYDISRDNTRDKNYMFPALLPLNSETHGGDDVGVFARGPxAH LFTGVYEQHVIPHMMAFASCIGRGLTACWAR------------------- ---- >Tsi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------MH PLLNDVPTRTSRSVRDEQ-------------------------------- -------------------------------------------------- -------------------------------GRAKNVILFLGDGMSIPTL AAARAYLGQRSGQTGEEVSLSFEQFPYTGLSKTYCVDRQVADSACTSTAY FCGVKNNYGTLGVSAAVTRRDCQAMRNTSNHVDSILAWA----------- ------------------------------------QDAGKSTGLVTTTR ITHASPAGGYSHTAERNWESDADVASNNADPHQCADIAKQLVRNSPGKNV K------Vxxxxxxxxxx-------------------------------- ------------------GSV---WGTQVVLGGGRRAFRPNTVKDEEGKR GVRIDGVDLVDEWKRDKLRRGASSSYAWDRDGLLGVNTDTTEYLL----- ------G------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxxxxxx----------- ---x >Tce -----------------------------------------x-------- -------------------------------------------------- -------------------xxxxxxxxxxxxxxxxxDRYPGRGDIVTVQR QEGRYCHWSETGWEILSLFRDKRGDIVTVRRxxxxxxxxxxxxGEI---- ------------------------------FKAMxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxx------------------------- -------------------------------------------------- --------------------------------------------NESVMH PLLDDVPTRSSRSVRGEQGIGKVGSEEVNQNSRGGRVENHLGKTTPSSPD RDSNLDxPxLSSRAQHDKRCSSLSCPTD---------------------- ---------ASYWTTNAQEQLWRHATQQPILGRAKNVILFLGDGMSIPTL AATRAYLGQRSGQTGEEVSLSFEQFPYTGLSKTYCVDRQVADSACTSTAY FCGVKNNYGTLGVSAAVTRRDCQAMRNSSNHVDSILAWA----------- ------------------------------------QDAGKSTGLVTTTR ITHASPAGGYSHTAERNWESDADVASNNADPHQCADIAKQLVRNSPGKNV K------Vxxxxxxx----------------------------------- --------------------xxxxWGTQVVLGGGRRAFRPNTVKDEEGKR GVRIDGVDLVDEWKRDKLRRGASNSFAWDRNGLLGVNTDTTEYLL----- ------GLFDPNHMQYHLDADPTTEPTLPEMTATAIKMLQKDKAGFFLFV ExxxxxxTTxxxxxxx---------------------------------- -------------------------------------------------- ---------xxxxxxxx--------------------------------- ------xxxxxxxxxxxAx---------------xxxxxxxVQFHEAVRV AAELTDExxxxxxxxxxxxxVMSYSGYPTRGNDIL--------------- ----------------------xVGRFRNIFPRSxxxxxxxxVYTxV--- -----------------------------SDYHVLDRLNDMFGETSHMGP LGPFINVELMFxxxxxxxxxxxxVCSRLSWNEGxPAxxxxxVGCxACEAG RFTTVMFWENxxxxxxVANIVRIKTHHIGYCLIINTYCNDDVMYCAVETV IALMCAVETVIVTLC----------AxIAGNSIVDRLPYSTISYGxxxxx xxxxxxxxxYDISRDNTKDKNYMFPALLPLNSETHGGDDVGVFARGPxAH LFTGVxEQHVIPHMMAFASCIGRGLTACWAR------------------- ---- >Tbi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------------MSIPTL AATRAYLGQRSGQTGEEVSLSFEQFPYTGLSKTYCVDRQVADSACSSTAY FCGVKNNYGTLGVSATVTRRDCQAMRNSSNHVDSILVWA----------- ------------------------------------QDAGKSTGLVTTTR ITHASPAGGYSHTADRNWESDADVASNNADPHQCADIAKQLVRNSPGKNV K------V---------SGLPQGxxxIRFIQDKGKVIVSSGAL------- -------EIGGHK-----GSV---WGTQVVLGGGRRAFRPNTVKDEEGQR GVRIDGADLVDEWKRNKLRRGASNSYVWDRDGLLGVNTDTTEYLL----- ------GLFDHNHMQYHLDADPTTEPTLPEMTATAIKMLQKDKAGYFLFV E--------------x---------------------------------- -------------------------------------------------- ---------xxxxxxxx--------------------------------- ------xx------------------------------------------ -------------------------------------------------- ----------------------------------------------xxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---- >Tcm -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------MH PLLNDVPTRTSRSVRDEQ-------------------------------- -------------------------------------------------- -------------------------------GRAKNVILFLGDGMSIPTL AAARAYLGQRSGQTGEEVSLSFEQFPYTGLSKTYCVDRQVADSACTSTAY FCGVKNNYGTLGVSAAVTRRDCQAMRNTSNHVDSILAWA----------- ------------------------------------QDAGKSTGLVTTTR ITHASPAGGYSHTAERNWESDADVAR------------------------ -------------------------------------------------- -------------------xV---WGTQVVLGGGRRAFRPNTVKDEEGKR GVRIDGVDLVDEWKRDKLRRGASSSYAWDRDGLLGVNTDTTEYLLAPAKE VLCPVSGLFDDNHMQYHLDADPTTEPTLPEMTATAIKMLQKDKAGYFLFV E------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------xGxxxHxHHGTSAxKALDETVQFHEAVRV AAELTDEKDTLIVVTSDHAHVMSYSGYPTRGNDIL--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------x----------------------- -------------------------------------------------- --------------------------------------xxxxxxxxxxxx xxxx