>Tge ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------LD----------------------------- -------------NAVDLDNNVDGLDNNVDSLDNAVDLDNNVDGLDNNVDSLDNAVDLDN NVDGLDNGVGLNNNADGLNNNVDGLNNNVDLDNNVDGLDSKVDGLDNNILVMENLESTAV AVDVPGNMVAISSPRVREMSDRTEERVVGGQASQPGAWPWIVALYKDGSFHCGGVILNPS WVMTAAHCVDEFEHHYYEVRAGMLRRLSFAPSEQLRAVSGVSAHSKYDRTVMKNDLALLR LRDSLRLNRWVRQICLPRVSPRPFTVCTAVGWGATQEHGLD------------------- ------------------------------------------------------------ -PDHMREVELPILSECKHKEDSEGHEICAGMEEGGRDACQGDSGGPLLCRDTSNPHRWYV AGVVSHGEGCARPDEPGAYTRVSLFVSWIQNTIREYQESSKRPRSKCPGMHCPPSQRCIP QHKICDGVVDCLGAEDELNCRPKSKASEGNQTSRKCQKGRKKVSGP---TSPLDAPSRST NHSATL--SENGLHGSRANVFEEVIEDARDIINNISSELNLRLPNATNIISTNNISTQNQ TGSTNRPSSVIVSNNNSVPEVT--LVKNGSVLQTNMTSSPASGAVVTTLSTLSNIQGDMT SSEELLLVTTATTPKTSELGSTVRELGDVIGSTRSFTETNQDSLTTSFISPTFLTSSTTE ESLNITGPPVGKPDTLETDASVDKVIGSSNKPEIMTATEDMMSTTQNILVKPQNVSTLIN QSNKTI-DQIDVDNRVLPAIDSFITGVSNTTVTP----------SLATETTVTTVTPSLA TEATVTTVIPSLATEATVTT----------VIPSLATEA--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >Tbi ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------NNVDG---------------------------------LDN NVDGLD-------------NNVDG------LDNNVDGLDS-------NILVMENLESTAV AVDVPGNMAAISSPRVREMSDRTEERVVGGQASQPGAWPWIVALYKDGSFHCGGVILNPS WVMTAAHCVDEFEHHYYEVRAGMLRRLSFAPSEQLRAVSGVSAHNKYDRTVMKNDLALLR LKDSLRLNRWVRQICLPRVSPRPFTVCTAVGWGATQEHGLD------------------- ------------------------------------------------------------ -PDHMREVELPILSECKHKEDSEGHEICAGMEQGGRDACQGDSGGPLLCRDTSNPHRWYV AGVVSHGEGCARPDEPGAYTRVSLFVSWIQNTIREYQESSKRPRSKCPGMHCPPSQRCIP QHKICDRVVDCLGAEDELNCRPKSKASEGNQTSSKCQKGRKKVSGP---TSPLDAPSRST NHSATL--SENGLHDSRANVFEEVIEDARDIINNISSELNLRLPNATNKTSTNNISTQNQ TGSTNRPSSGIVQNNNSVPEVTLILVKNGSVLQTNLTSSPANGAVVTTLSTLSNIQGDMT SSEELLLVTTATTPKTSEFSSTVRELGDVIGSTRSSIETNQDSLTTSFISATFLMSSTTE ESLNITEPPVGKPDTLETVASVDKVTGSSDKPEIMTATEDMMSTTQNIIVKPQNVSTLTN QSNKTI-DQIDVDNRVLPAIDSFITVVSNTTNTP----------SLATETTVTTVTPSLA TETTVTTVTPSLATETT------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >Tte ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------NNVDG---------------------------------LDS NVDGLD-------------SNVDG------LDSNVDGLDSKVDGLHNNILVMENLESTAV AVDVPGNMAAISSPRVREMSDRTEERVVGGQASQPGAWPWIVALYKDGSFHCGGVILNPS WVMTAAHCVDEFEHHYYEVRAGMLRRLSFAPSEQLRAVSGVSAHNKYDRTVMKNDLALLR LKDSLRLNRWVRQICLPRVSPRPFTVCTAVGWGATQEHGLD------------------- ------------------------------------------------------------ -PDHMREVELPILSECKHKEDSEGHEICAGMEQGGRDACQGDSGGPLLCRDTSNPHRWYV AGVVSHGEGCARPDEPGAYTRVSLFVSWIQNTIREYQESSKRPRSKCPGMHCPPSQRCIP QHKICDGVVDCLGAEDELNCRPKSKASEGNQTSSKCQKGRKKVSGP---TSPLDAPSRST NHSATL--SENGLHDSRANVFEEVIEDARDIINNISSELNLRLPNATNKTSTNNISTQNQ TGSTNRPSSGIVQNNNSVPEVTLILVKNGSVLQTNLTSSPANGAVVTTLSTLSNIQGDMT SSEELLLVTTATTPKTSEFSSTVRELGDVIGSTRSSIETNQDSLTTSFISATFLMSSTTE ESLNITEPPVGKPDTLETVASVDKVTGSSDKPEIMTATEDMMSTTQNIIVKPQNVSTLTN QSNKTI-DQIDVDNRVLPAIDSFITVVSNTTNTP----------SLATETTVTTVTPSLA TETIVTTVTPSLATE--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >Tce QQQLQHYPQQQLQQYPQQLFYPPTGFSAQIQPLFSPFSPRLCSYYLPTLQFPTVPGTAGG TRQDTSVQGDFIHPTVVGEDGELRAAAGQKSNGSGSPQTDYHGQTGDISQVPVSRADDCP PGQVACSEGIHCVTESQWCDGEVHCVDASDEKSCSCQDRVDSNRLCDGYFDCPQGEDELG CFGCSEVSFSCGDSSHHKGVLCVPLIRRCDGHPDCSNGKDEEDCSVITDTLVHTQDLLVS YSSGLLHHNWQGVWYPVCSFEMVWATAACDSEVGMRDSTRDHLQLHPLSEPHATLFVAPQ PNGQATFLHNCNGYISHVTCAPVPCGTRLLDSRDLRRGEMDDDVTRLKKRFRRTRDTDRR AHRDSVFLHTLGINNVDPDNNVDGLSNNVDS-------DSNVDGSDNGVDSYNNVDGLNN NLNGLDNGINL--------DNVDGLSNNVDLDNNVDGLDNNA-VLDNKIVVMKHLEST-- AVDVPGNMAAISSPRVREMSDRTEERVVGGQASQPGAWPWIVALYKDGSFHCGGVILNPS WVMTAAHCVDEFEHHYYEVRAGMLRRLSFSPSEQLRAVSGVSAHSKYDRTVMKNDLALLR LKDSLRLNRWVRQICLPRVSPRPFTVCTAVGWGATKEHGPD------------------- ------------------------------------------------------------ -PDHMREVELPILSECKHREDSEGHEICAGMEEGGRDACQGDSGGPLLCRDTSNPHRWYV AGVVSHGEGCARPDEPGAYTRVSLFVSWIQNTIREYQESSKRPRAKCPGMHCPPSQRCIP QHKICDGVVDCLGAEDELNCQPKSKASEGNQTSRKCQKGRKKVSGPSSPTSPPDAPSSST NHSVTLSESEDSLHGSRANVFEEVIDDARDIINNISSALNLRLPNATNIISTNNISTQNQ TRSTNRPSSVIVQNNTSVPEVTLVLVKNGSLLQNNLTSSLASGAVVTTLTTLSDIQGDMT SSEELLLVTTATTPKTSVFSSTVGEL----GSTRPFTETKQDSLTTSFVSVTFLTSSTTE EHFNITEPPVGRPDTLE--------------------TEDMMSTTQNILVKPQNVSTLVN ESNKTINNQTDVHNKVLTAIDSFIALVSNTTVTS----------SLATETTVTTVTPSLA TEETVTTVTP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >Tdi ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----MREVELPILSECKHREDTEGHEICAGMEEGGRDACQGDSGGPLLC----------- ----SHGEGCARPDEPGAYTRVSLFVSWIQNTI--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >Tsi ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------LSLFLLPR EQG--------------------------------------------------------- ------------------------------------------------------------ -----------------------------DLDSGLQDLGS-------------------- ----------------------------------------ILSLF--------------- --------LMSFEHHYYEVRAGMLRRLSFSPSEQLRAVSGVSAHSKYDRTVMKNDLALLR LKDSLRLNRWVRQICLPRVSPRPFTVCTAVGWGATKEHGPD------------------- ------------------------------------RKYLRGVGGHQGARPRPSCEQARV SADHMREVELPILSECKHREDTEGHEICAGMEEGGRDACQGDSGGPLLCRDTNNPHRWYV AGVVSHGEGCARPDEPGAYTRVSLFVSWIQNTIREYQESSKRPRTECPGMHCPPSQRCIP QHKICDGVVDCLGAEDELNCRPKSKASEGNQTSRKCQKGRKKVSGPSSLTPPPDAPSRST NHSVTLSESEEGLHGSRANVFEEVIEDARDIINNISSELNLRLPNATNIISTNNTPTQSQ TGSANRPSSVIVQNNTSVPEVTLVLVKNGSLLQTDLTSSPASGAVVTTSTTVADIQGDMT SSEELLLATTATTPETGVFSSTAGELGDVMGSTPSFTETKQDSSTTSIASATFLTSSTTE ESFNITEPPVGRPDTLE--------TGSPDKPEIITETEDMMSTTQNILVKPQ------N ESNKTINNQTDVHNGVLPAIDSFIASVSNTTITPLLATEETDTTSLATEATVTTITPLLA TEATVTTITPLLATERTVTT----------ITPLLATETTVTTITPSLATETTVTTITPS LTTEETVTTITPSLATETTVTNLLDTKIPTMILTTTSTTDKTPPVSNTNKVPEFVLSSVS GMRQSTGTSSVDDLERTTKTSDIITLKVSHGSTTDSAPQKLSLPLSSAGP----VVTANE NDVILQTNEETGVSAPDS----GTSAAAMTLPLPATRAPTQVSPGVSREVYSCTRIQQNI PADRRCDRTLDCEDGSDEVNCTCREYLLYSHPHVLCDGNIDCADRTDELDCRPCL----- -VSLYCSRAVSSVTVLFQGRVSQQSITVPPVTSVSLSHSGMREVHQQGSLPALHLPGRRN PPCPPLAGETHPSLPSTCRGDASLPALHLPGRRILTDTILLSIVALTDGSTVFLGLDARP QLFSEGVISYSLLGEWHPLCDDGKKEYSRMAADICGLLDFRSYPCKYCWGSGRIRATIAG VQVVSVQLLLGFRSYLCNYCLGSGRICATIAGVQVVSVQLLLGFRSYLCNYCWGSGRISA TIAGVQVVSVQLLLGVYRDYVTAQLGVPRPELGVLTLWEQLIRVDEAKPVLQTEVVLLHL ERAPALNRHVWPLVLLQEYSAPQSSYECVALGQDSDNAVVSLRLKPMLSFVEPGEIYFHG LEQTEDCTDSTNTFPWSGVVACRQKRGWYPAGVYYQPDGLCGFKYDTHAVSVVDILPHIR ATMGQWGFAPTSGDIGLQTIVPTMGQWGFAPTSGDIGLQTIVPTMDQWGFAPTSGDIGLQ TIVPTISIRTLI >Tcm ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------SRDTNNPHRWYV AGVVSHGEGCARPDEPGAYTRVSLFVSWIQNTIREYQESSKRPRTECPGMHCPPSQRCIP QHKICDGVVDCLGAEDELNCRPKSKASEGNQTSRKCQKGRKKVSGPSSLTPPPDAPSRST NHSVTLSESEEGLHGSRANVFEEVIEDARDIINNISSELNLRLPNATNIISTNNTPTQSQ TGSANRPSSVIVQNNTSVPEVTLVLVKNGSLLQTDLTSSPASGAVVTTSTTVADIQGDMT SSEELLLATTATTPETGVFSSTAGELGDVMGSTPSFTETKQDSSTTSIASATFLTSSTTE ESFNITEPPVGRPDTLE--------TGSPDKPEIITETEDMMSTTQNILVKPQ------N ESNKTINHQTDVHNGVLPAIDSFIASVSNTTITPLLATEETDTTSLATEATVTTITPLLA TEATVTTITPLLATERTVTT----------ITPLLATETTVTTITPSLA----------- --TEETVTTITPSLATETTVTNLLATKIPTMILTTTSTTDRTPPVSNTNKAPEFVLSSVS GMRESTGTTSVDDLERTTKTSDIITLKVSHGSTTDSAPQKLSLPLSSAGP----VVTANE NDVILQTTEETGVSAPDS----GTSAAAMTLPLPATRAPTQVSPGVSREVYSCTRIQQNI PADRRCDRTLDCEDGSDEVNCTCREYLLYSHPHVLCDGNIDCADRTDELDCRPCL----- -VSLYRSRAVSSVTVLFQGRV--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >Tms ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------MGIYWDAGFQ--------- W------------------------SLIVPPTD--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------LGEYQESSKRPRAKCPGMHCPPSQRCIP QHKICDGVVDCLGAEDELNCQPKSKASEGNQTSRKCQKGRKKVSGPSSPTSPPDAPSSST NHSVTLSESEDSLHGSRANVFEEVIDDARDIINNISSALNLRLPNATNIISTNNISTQNQ TRSTNRPSSVIVQNNTSVPEVTLVLVKNGSLLQNNLTSSLASGAVVTTLTTLSDIQGDMT SSEELLLVTTATTPKTSVFSSTVGEL----GSTRPFTETKQDSLTTSFVSAALLTSSTTE EHFNITEPLVGRPDTLE--------------------TEAMMSTTQNILVKPQNVSTLVN ESNKTINNQTDVHNKVLPAIDSFIALVSNTTVTS----------SLATETTVTTVTPSLA TETTVTTVTPSLATEETGTTLLAIETTVTTVTPSLATEETGTTVTPSLATEETGTT---L LATETTVTTVTPSLATEAIVTTLLATEIPIMILTTTSTTDKTPPVSNINEVTEFVLTSVS GIRQSTGTTSVDDLEQTTKTSDIITLRVLHNLTTGSTSQKLSPSLSSAGPEAWSVVTANE NNVILETTEETEVSAPNNGSEVGTSVVAMTLPLPATRAPTQVSPGAAREVYSCTRIHQNI PADRRCDRTLDCEDGSDEVNCTCREYLLYSHPHILCDGNIDCADRTDELDCSELIHESSY TVQLYCSRAMSSVTVLFHGNV--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >Tps ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------EYQESSKRPRTKCPGMHCPPSQRCIP QHKICDGVVDCLGAEDELHCRPKSKASEGNQTSRKCQKGGKKVSGPSSLTSPPDAPSRST NHSVTLSESEDGHHGSRANVFEEVIEGARDIINNISSELNLRLPNATNIISTNNTPTQNQ TRSTNRPSSVIVQNNTSVPEVTLVLVKNGSLLQTNLTSSPASGAVVTTLTTLSDIQGDMT SSEELLLVTTATTPETSVIGSTVGELGDVIGSTPSFTETKQDSSTTSFVRATFPTSSTTG ESFNITEPPVGQPDTLETDASVDKITGSSDKPEIITETEDTMSTAQNILVKPQNVSTLVN ESNKTINNQTDVHNGVLPAIDSFIALVSNTTVTP----------SLATEATDTT---SLA TEATDTT---SLATEETDTT-------------SLATEETDTT---SLASEATDTT---S LATETTVTT---SLATEAIVTTSLATEIPILILTTTSTTDKTPPVSNTNQVTEFVLTSVS GMRQSTGTTSVDDLERTTKTSDVTTLKVSHSSTTDSAPQKLSLSSSSAGPEAWSVVTANE NNVTLQTTEGTGVSAPDSGSEVGTSAVAMTLPLPATRAPTQVSPGVAREVYSCTRIQQNI PADRRCDRTLDCEDGSDEVNCTCREYLLYSHPHVLCDGNIDCADRTDELDCSELIYE--- --------AVSSVAVLFHGRV--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >Tpa ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MENLEGTVV AVDVPGNMAAISSPRVREMSDRTEERVVGGQASQPGAWPWIVALYKDGSFHCGGVILNPS WVMTAAHCVDEFEHHYYEVRAGMLRRLSFAPSEQLRAVSGVSAHSKYDRTVMKNDLALLR LRDSLRLNRWVRQICLPRVSPRPFTVCTAVGWGATQEHGLDLPPGVGDTKEXRGVGDTKE HGLDCKYHRGVGDTKEHGLDRKYRRGVGDTKEHGPDRKYPRGVGG---------TKEHGL DPDHMREVELPILSECKHKEDSEGHEICAGMEEGGRDACQGDSGGPLLCR---------- -----------------------------------YSE---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------