>Tge LD------------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------------NA VDLDxxxxxxxxxxDSLDNAVDLDNNVDGLDxxxxxxxxxxDxxxxxxxx xxGVGLNxxxxxxxx------------xxxxxxxxxx--------xxxxx xxxxxxxxxxDNNILVMENLESTAV--------------AVDVPGNMVAI SSPRVREMSDRTEERVVGGQASQPGAWPWIVALYKDGSFHCGGVILNPSW VMTAAHCVDEFEHHYYEVRAGMLRRLSFAPSEQLRAVSGVSAHSKYDRTV MKNDLALLRLRDSLRLNRWVRQICLPRVSPRPFTVCTAVGWGATQ----- -------------------------------------------------- ----------------EHGLD-------------------------PDHM REVELPILSECKHKEDSEGHEICAGMEEGGRDACQGDSGGPLLCRDTSNP HRWYVAGVVSHGEGCARPDEPGAYTRVSLFVSWIQNTIREYQESSKRPRS KCPGMHCPPSQRCIPQHKICDGVVDCLGAEDELNCRPKSKASEGNQTSRK CQKGRKKVSG---xTSPLDAPSRSTNHSATL--SENGLHGSRANVFEEVI EDARDIINNISSELNLRLPNATNIISTNNISTQNQTGSTNRPSSVIVSNN NSVPEVT--LVKNGSVLQTNMTSSPASGAVVTTLSTLSNIQGDMTSSEEL LLVTTATTPKTSELGSTVRELGDVIGSTRSFTETNQDSLTTSFISPTFLT SSTTEESLNITGPPVGKPDTLETDASVDKVIGSSNKPEIMTATEDMMSTT QNILVKPQNVSTLINQSNKTI-xQIDVDNRVLPAIDSFITGVSN------ -------------------------------------------xxx---- -----------------------TPxxxxxxxxxxVTPSxx--------- ----xxxTVTTVxx------------------------------------ -----------------------xxxxxxxxx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxxx >Tbi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x------------NxxxLxxxxxxxxxxxxxxxxxx xxxxx-------NILVMENLESTAV--------------AVDVPGNMAAI SSPRVREMSDRTEERVVGGQASQPGAWPWIVALYKDGSFHCGGVILNPSW VMTAAHCVDEFEHHYYEVRAGMLRRLSFAPSEQLRAVSGVSAHNKYDRTV MKNDLALLRLKDSLRLNRWVRQICLPRVSPRPFTVCTAVGWGATQ----- -------------------------------------------------- ----------------EHGLD-------------------------PDHM REVELPILSECKHKEDSEGHEICAGMEQGGRDACQGDSGGPLLCRDTSNP HRWYVAGVVSHGEGCARPDEPGAYTRVSLFVSWIQNTIREYQESSKRPRS KCPGMHCPPSQRCIPQHKICDRVVDCLGAEDELNCRPKSKASEGNQTSSK CQKGRKKVSG---xTSPLDAPSRSTNHSATL--SENGLHDSRANVFEEVI EDARDIINNISSELNLRLPNATNKTSTNNISTQNQTGSTNRPSSGIVQNN NSVPEVTLILVKNGSVLQTNLTSSPANGAVVTTLSTLSNIQGDMTSSEEL LLVTTATTPKTSEFSSTVRELGDVIGSTRSSIETNQDSLTTSFISATFLM SSTTEESLNITEPPVGKPDTLETVASVDKVTGSSDKPEIMTATEDMMSTT QNIIVKPQNVSTLTNQSNKTI-DQIDVDNRVLPAIDSFITVVSN------ -------------------------------------------xxx---- -----------------------xxxxxxxxxxxxxxxxxx--------- ----xxxxxxxxxx------------------------------------ -----------------------SLATETx-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----- >Tte -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------x------------xVDGxxxxxxxxxxxxxxxxxxx xxxxxxxxxxHNNILVMENLESTAV--------------AVDVPGNMAAI SSPRVREMSDRTEERVVGGQASQPGAWPWIVALYKDGSFHCGGVILNPSW VMTAAHCVDEFEHHYYEVRAGMLRRLSFAPSEQLRAVSGVSAHNKYDRTV MKNDLALLRLKDSLRLNRWVRQICLPRVSPRPFTVCTAVGWGATQ----- -------------------------------------------------- ----------------EHGLD-------------------------PDHM REVELPILSECKHKEDSEGHEICAGMEQGGRDACQGDSGGPLLCRDTSNP HRWYVAGVVSHGEGCARPDEPGAYTRVSLFVSWIQNTIREYQESSKRPRS KCPGMHCPPSQRCIPQHKICDGVVDCLGAEDELNCRPKSKASEGNQTSSK CQKGRKKVSG---xTSPLDAPSRSTNHSATL--SENGLHDSRANVFEEVI EDARDIINNISSELNLRLPNATNKTSTNNISTQNQTGSTNRPSSGIVQNN NSVPEVTLILVKNGSVLQTNLTSSPANGAVVTTLSTLSNIQGDMTSSEEL LLVTTATTPKTSEFSSTVRELGDVIGSTRSSIETNQDSLTTSFISATFLM SSTTEESLNITEPPVGKPDTLETVASVDKVTGSSDKPEIMTATEDMMSTT QNIIVKPQNVSTLTNQSNKTI-xQIDVDNRVLPAIDSFITVVSN------ -------------------------------------------xxx---- -----------------------TPxxxxxxxxxxVTPSxx--------- ----xxxIVTTVxx------------------------------------ -----------------------xxxxx---------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----- >Tce xxQLQHYPQQQLQQYPQQLFYPPTGFSAQIQPLF---------------- ---------SPFSPRLCSYYLPTLQFPTVPGTAGGTRQDTSVQGDFIHPT VVGEDGELRAAAGQKSNGSGSPQTDYHGQTGDISQVPVSRADDCPPGQVA CSEGIHCVTExxWCDGEVHCVDASDEKSCSCQDRVDSNRLCDGYFDCPQG EDELGCFGCSEVSFSCGDSSHHKGVLCVPLIRRCDGHPDCSNGKDEEDCS VITDTLVHTQDLLVSYSSGLLHHNWQGVWYPVCSFEMVWATAACDSEVGM RDSTRDHLQLHPLSEPHATLFVAPQPNGQATFLHNCNGYISHVTCAPVPC GTRLxxSRDLRRGEMDDDVTRLKKRFRRTRDTDRRAHRDSVFLHTLxxNN VDPDxxxxxxxxxxxx---------------------------xxxxxxx xNGVDSYxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-xxxxxxxxxxx- -----------------------xxxxxxxxxxxxxxxxAVDVPGNMAAI SSPRVREMSDRTEERVVGGQASQPGAWPWIVALYKDGSFHCGGVILNPSW VMTAAHCVDEFEHHYYEVRAGMLRRLSFSPSEQLRAVSGVSAHSKYDRTV MKNDLALLRLKDSLRLNRWVRQICLPRVSPRPFTVCTAVGWGATK----- -------------------------------------------------- ----------------EHGPD-------------------------PDHM REVELPILSECKHREDSEGHEICAGMEEGGRDACQGDSGGPLLCRDTSNP HRWYVAGVVSHGEGCARPDEPGAYTRVSLFVSWIQNTIREYQESSKRPRA KCPGMHCPPSQRCIPQHKICDGVVDCLGAEDELNCQPKSKASEGNQTSRK CQKGRKKVSGPxxPTSPPDAPSSSTNHSVTLxxSEDSLHGSRANVFEEVI DDARDIINNISSALNLRLPNATNIISTNNISTQNQTRSTNRPSSVIVQNN TSVPEVTLVLVKNGSLLQNNLTSSLASGAVVTTLTTLSDIQGDMTSSEEL LLVTTATTPKTSVFSSTVGEL----GSTRPFTETKQDSLTTSFVSVTFLT SSTTEEHFNITEPPVGRPDTLE--------------------TEDMMSTT QNILVKPQNVSTLVNESNKTIxNQTDVHNKVLTAIDSFIALVSN------ -------------------------------------------xxx---- -----------------------TSxxxxxxxxxxVTPSxx--------- ----xxxTVTTVxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----- >Tdi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------M REVELPILSECKHREDTEGHEICAGMEEGGRDACQGDSGGPLLC------ ---------SHGEGCARPDEPGAYTRVSLFVSWIQNTI------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----- >Tsi xx------------------------------xxxxxxxxxxxxxxxxxx xxxxxxxxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------FEHHYYEVRAGMLRRLSFSPSEQLRAVSGVSAHSKYDRTV MKNDLALLRLKDSLRLNRWVRQICLPRVSPRPFTVCTAVGWGATK----- -------------------------------------------------- ----------------EHGPDxKYLRGVGGHQGARPRPSCEQAxxxADHM REVELPILSECKHREDTEGHEICAGMEEGGRDACQGDSGGPLLCRDTNNP HRWYVAGVVSHGEGCARPDEPGAYTRVSLFVSWIQNTIREYQESSKRPRT ECPGMHCPPSQRCIPQHKICDGVVDCLGAEDELNCRPKSKASEGNQTSRK CQKGRKKVSGPSSLTPPPDAPSRSTNHSVTLSESEEGLHGSRANVFEEVI EDARDIINNISSELNLRLPNATNIISTNNTPTQSQTGSANRPSSVIVQNN TSVPEVTLVLVKNGSLLQTDLTSSPASGAVVTTSTTVADIQGDMTSSEEL LLATTATTPETGVFSSTAGELGDVMGSTPSFTETKQDSSTTSIASATFLT SSTTEESFNITEPPVGRPDTLET--------GSPDKPEIITETEDMMSTT QNILVKPQ------NESNKTIxNQTDVHNGVLPAIDSFIASVSNxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxI---- -----------------------TPLLATETTVTTIxxxxxTETTVxxIx xxxxxxxxxxxxxx------------------------------------ -----------------------SLATETTVTNLLDTKIPTMILTTTSTT DKTPPVSNTNKVPEFVLSSVSGMRQSTGTSSVDDLERTTKTSDIITLKVS HGSTTDSAPQKLSLPLSSAGP----VVTANENDVILQTNEETGVSAPDS- ---GTSAAAMTLPLPATRAPTQVSPGVSREVYSCTRIQQNIPADRRCDRT LDCEDGSDEVNCTCREYLLYSHPHVLCDGNIDCADRTDELDC-------- ---xxxxVSLYCSRAVSSVTVLFQGRVSQQSITVPPVTSVSLSHSGMREV HQQGSLPALHLPGRRNPPCPPLAGETHPSLPSTCRGDASLPALHLPGRRI LTDTILLSIVALTDGSTVFLGLDARPQLFSEGVISYSLLGEWHPLCDDGK KEYSRMAADICGLLDFRSYPCKYCWGSGRIRATIAGVQVVSVQLLLGFRS YLCNYCLGSGRICATIAGVQVVSVQLLLGFRSYLCNYCWGSGRISATIAG VQVVSVQLLLGVYRDYVTAQLGVPRPELGVLTLWEQLIRVDEAKPVLQTE VVLLHLERAPALNRHVWPLVLLQEYSAPQSSYECVALGQDSDNAVVSLRL KPMLSFVEPGEIYFHGLEQTEDCTDSTNTFPWSGVVACRQKRGWYPAGVY YQPDGLCGFKYDTHAVSVVDILPHIRATMGQWGFAPTSGDIGLQTIVPTM GQWGFAPTSGDIGLQTIVPTMDQWGFAPTSGDIGLQTIVPTISIRTLI-- ----- >Tcm -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------SRDTNNP HRWYVAGVVSHGEGCARPDEPGAYTRVSLFVSWIQNTIREYQESSKRPRT ECPGMHCPPSQRCIPQHKICDGVVDCLGAEDELNCRPKSKASEGNQTSRK CQKGRKKVSGPSSLTPPPDAPSRSTNHSVTLSESEEGLHGSRANVFEEVI EDARDIINNISSELNLRLPNATNIISTNNTPTQSQTGSANRPSSVIVQNN TSVPEVTLVLVKNGSLLQTDLTSSPASGAVVTTSTTVADIQGDMTSSEEL LLATTATTPETGVFSSTAGELGDVMGSTPSFTETKQDSSTTSIASATFLT SSTTEESFNITEPPVGRPDTLET--------GSPDKPEIITETEDMMSTT QNILVKPQ------NESNKTIxHQTDVHNGVLPAIDSFIASVSNxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---- -----------------------TxxxxxxxxxxxIxxxxx--------- ----xxxxxxxITP------------------------------------ -----------------------SLATETTVTNLLATKIPTMILTTTSTT DRTPPVSNTNKAPEFVLSSVSGMRESTGTTSVDDLERTTKTSDIITLKVS HGSTTDSAPQKLSLPLSSAGP----VVTANENDVILQTTEETGVSAPDS- ---GTSAAAMTLPLPATRAPTQVSPGVSREVYSCTRIQQNIPADRRCDRT LDCEDGSDEVNCTCREYLLYSHPHVLCDGNIDCADRTDELDC-------- ---RPCLVSLYRSRAVSSVTVLFQGRV----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----- >Tms x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxxxxxx----------- --------------------------------------------xxxxxx xxxxxx-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------EYQESSKRPRA KCPGMHCPPSQRCIPQHKICDGVVDCLGAEDELNCQPKSKASEGNQTSRK CQKGRKKVSGPSSPTSPPDAPSSSTNHSVTLSESEDSLHGSRANVFEEVI DDARDIINNISSALNLRLPNATNIISTNNISTQNQTRSTNRPSSVIVQNN TSVPEVTLVLVKNGSLLQNNLTSSLASGAVVTTLTTLSDIQGDMTSSEEL LLVTTATTPKTSVFSSTVGEL----GSTRPFTETKQDSLTTSFVSAALLT SSTTEEHFNITEPLVGRPDTLExxx--------------------MMSTT QNILVKPQNVSTLVNESNKTIxNQTDVHNKVLPAIDSFIALVSNxxx--- -------------------------------------------------- -----------------------TSxxxxxxxxxxVTPxxx--------- ----xxxxxTxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxVxx xxxxxxxxxxxxxxxxxxxxxxxSLATEAIVTTLLATEIPIMILTTTSTT DKTPPVSNINEVTEFVLTSVSGIRQSTGTTSVDDLEQTTKTSDIITLRVL HNLTTGSTSQKLSPSLSSAGPEAWSVVTANENNVILETTEETEVSAPNNx SEVGTSVVAMTLPLPATRAPTQVSPGAAREVYSCTRIHQNIPADRRCDRT LDCEDGSDEVNCTCREYLLYSHPHILCDGNIDCADRTDELDCxxxxxxSS YTxQ-----LYCSRAMSSVTVLFHGNV----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----- >Tps -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------EYQESSKRPRT KCPGMHCPPSQRCIPQHKICDGVVDCLGAEDELHCRPKSKASEGNQTSRK CQKGGKKVSGPxxLTSPPDAPSRSTNHSVTLxxSEDGHHGSRANVFEEVI EGARDIINNISSELNLRLPNATNIISTNNTPTQNQTRSTNRPSSVIVQNN TSVPEVTLVLVKNGSLLQTNLTSSPASGAVVTTLTTLSDIQGDMTSSEEL LLVTTATTPETSVIGSTVGELGDVIGSTPSFTETKQDSSTTSFVRATFPT SSTTGESFNITEPPVGQPDTLETDASVDKITGSSDKPEIITETEDTMSTA QNILVKPQNVSTLVNESNKTIxNQTDVHNGVLPAIDSFIALVSNxxxxxx xxxxxxxxxxxxxxxxx--------------------------xxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--------------- -------------------------------------------------- -----------------------SLATEAIVTTSLATEIPILILTTTSTT DKTPPVSNTNQVTEFVLTSVSGMRQSTGTTSVDDLERTTKTSDVTTLKVS HSSTTDSAPQKLSLSSSSAGPEAWSVVTANENNVTLQTTEGTGVSAPDSx SEVGTSAVAMTLPLPATRAPTQVSPGVAREVYSCTRIQQNIPADRRCDRT LDCEDGSDEVNCTCREYLLYSHPHVLCDGNIDCADRTDELDCSELIxx-- --------------AVSSVAVLFHGRV----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----- >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------xxxxxxTVV--------------AVDVPGNMAAI SSPRVREMSDRTEERVVGGQASQPGAWPWIVALYKDGSFHCGGVILNPSW VMTAAHCVDEFEHHYYEVRAGMLRRLSFAPSEQLRAVSGVSAHSKYDRTV MKNDLALLRLRDSLRLNRWVRQICLPRVSPRPFTVCTAVGWGATQxxxxx LPPGVGDTKEXRGVGDTKEHGLDCKYHRGVGDTKEHGLDxKYRRGVGDTK EHGPxxxxxxxxxGTKEHGLD-------------------------PDHM REVELPILSECKHKEDSEGHEICAGMEEGGRDACQGDSGGPLLCR----- ----------------------------------------YSE------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----