>Tge M------------------------------------------------- ---------------xxxxxRKVxxxxxxxxxxxxxxxxRLxxxxxxxxx xxxxATMQRTQRYTTxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxWSSGGxxxxxxxxxKSVWSSGxxx xxxxxxx-----------------------------xxxxEQWRNWSQPV PSNKGEKVTYDACKIWDRNYSSLTLDDLDLSQGHxLSAVPCTSWEFDVED TYGRTIISQWSLVxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------- ------KFGRRRLIVYNLVVVIPLQLCLPYLPSVELYIAIQFLLGVTGLG LYLSSYVLC----------------------------------------- --------------------------VELVDGKWRTIT------------ ----------------------------------GLANPLSNPT------ -------------------------------------------------- ----------------AFVSIAGIAYLLPRWDYLNLAISLPALLIFGIWL AIPESPRWLMTQGKKEEVMEVIKTAARCNKRTLPTNIEKQLDQ------- ------------------------FMS-RSSNEEQAxxxxxxxTPNLRRN TLLLYVEWFTINLIYxALVLNTGNIGGNIYVTSAILxxVEFSTVTRVSRK QKPQEVSISSCQCFRHCRVLHSHKGIKETETS------------------ -GGAVEYPAVALAILCMLKMGRRWPLSLSSIISGVACLLSLVVSPENPSG QWWVIMAAMIGKFCSAAASGIVFVTSLEIFPTVVRNVGLGTCQxxxxVAF LLTPFLWNLVSGHQGSDWSDVQPWLPMSILGASGIVGGxxxxxxPETSNR SFPHTLEDGEAISRxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------ -------------------------------xxxxxxxxxxxxxxxxxxx xxxxxxxxxxxYCESITLxHAAxxxxxxxxNPRVSSASPDTISSVSHTVE SNLWELSxxSGQGYIKxxxxxxxxxxxxxxxxxHTMERIVRFVVAMATVV TLAAAASSFKKPEYLESCPRNDNACLKKL--------------------L QVLIPKLSKGSNEFSLQPLDPMHIPEMNVVYQMGGNIRGNVSxxxxxxxx xxKIRINDVRSNVNDxHLSMEVDVKxxxVFVEGSxxANGLIVVFPINGKG VFNISMSDVSATWKLSGQVIERNEVxxxRLDHFNMxPVVGDMKFYASELF TGSDELS-----------------------------------------EC Qx >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------MTQGKKEEVMEVIKTAARCNKRTLPTNIEKQLDQ------- ------------------------FMS-RSGNEEQAxxxxxxxTPNLRRN TLLLYVEWFTINLIYxALVLNTGNIGGNIYVTSAIL-------------- -------------------------------------------------- --GAVEYPAVALAILCMLKMGRRWPLSLSSIISGVACLLSLVVS------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -- >Tms MAAPPEGEEKDPITEAVGEFGPWQLRLTFLLTLVNIPLMWRLDIPTYISL HSDYWCSRPSNLANISV--------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------EQWRNWSQPV SSNKDGKVTYDACKIWDRNYSGLTLGDLDLSQGHxLSAVPCTSWEFDVED SYGRTIISQWSLVxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------- ------KFGRRRLIVYNLVAVIPLQLCLPYLPSVELYITIQFLLGITGLG LYLSSYVLC----------------------------------------- --------------------------VELVDGKWRTIT------------ ----------------------------------GLANPLSNPT------ -------------------------------------------------- ----------------AFVSIAGIAYLLPRWDYLNLAISLPALLIFGIWL VIPESPRWLMTQGKKEEVMEVIKTAARCNKRTLPTNIEKQLDQ------- ------------------------FMS-RSSNEEQAxxxxxxxTPNLRRN TLLLYVEWFTINLIYxALVLNTGNIGGNIYVTSAIL-------------- -------------------------------------------------- --GVVEYPAVALAILCMLKMGRRWPLSLSSIGSGVACLLSLMVSPENPSG QWWVIMTAMIGKFCAAAASGIVFVTSLEIFPTVVRNVGLGTCQxxxxVAF LLTPFLWNL---------SDVQPWLPMSILGTSGIVGGxxxxxxPETSSR SFPHTLEDGEAISR------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxxxxxxxxxxxxxxxx -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -- >Tps MAAPPEGEEKDPITEAVGEFGPWQLRLTFLLTLVNIPLMWRLNIPTYISL HSDYWCSRPSNLANISV--------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------EQWRNWSQPV SSNKDGKVTYDACKIWDRNYSSLTLGDLDLSQGHxLSAVPCTSWEFDVED SYGRTIISQWSLVxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------- ------RFGRRRLIVYNLVVVIPLQLCLPYLPSVELYIAIQFLLGVTGLG LYLSSYVLC----------------------------------------- --------------------------VELVDGKWRTIT------------ ----------------------------------GLANPLSNPT------ -------------------------------------------------- ----------------AFVSIAGIAYLLPRWDYLNLAISLPALLIFGIWL AIPESPRWLMTQGKKEEVMEVIKTAARCNKRTLPTNIEKQLDQ------- ------------------------FMS-RSSNEEQAxxxxxxxTPNLRRN TLLLYVEWFTINLIYxALVLNTGNIGGNIYVTSAIL-------------- -------------------------------------------------- --GAVEYPAVALAILCMLKMGRRWPLSLSSICSGVACLLSLTVSPENPYG QWWVIMAAMIGKFCAAAASGIVFVTSLEIFPTVVRNVGIGACQxxxxVAF LLTPFLWNL---------SDVQPWLPMSILGASGIVGGxxxxxxPETSNR SFPHTLEDGEAISR------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------xxxxxxxxxxxxxxxxxxxxxxxx -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -- >Tdi MAAPPEGEEKDPITEAVGEFGPWQLRLTFLLTLVNISLMWRLSIPNYISL HSDYWCSRPSNLANIPV--------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------EQWRNWSQPV SSNKDGKVTYDACKIWDRNYSSLTLGDLDPxxxxxLSAVPCTSWEFDVED SYGRTIISQWSLVxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------- ------RFGRRRLIVYNLVVVIPLQLCLPYLPSVELYIAIQFLLGVTGLG LYLSSYVLC----------------------------------------- --------------------------VELVDGKWRTIT------------ ----------------------------------GLANPLSNPT------ -------------------------------------------------- ----------------AFVSIAGIAYLLPRWDYLNLAISLPALLIFAIWL AIPESPRWLMTQGKKEEVMEVIKTAARCNKRTLPTNIEKQLDQ------- ------------------------FMS-RSSNEEQAxxxxxxxTPNLRRN TLLLYVEWFTINLIYxALVLNTGNIGGNIYVTSAIL-------------- -------------------------------------------------- --GAVEYPAVALAILCMLKMGRRWPLSLSSIGSGVACLLSLTVSPE---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -- >Tte MGAPPEGEEKDPITEAVGEFGPWQLRLTFLLALVNIPLMWRLDIPTYISL HSDYWCSRPSNLANISV--------------------------------- -------------------------------------------------- -------------------------------------------------- ------xxWRNWSQPVSSNKVSLEQWRNWSKPxxxxxxxxEQWRNWSQPV SSNKGEKVTYDACNIWDRNYSSLTLDDLDLxxxxxLSAVPCTSWEFDVED TYGRTIISQ--------------------------------xxxxxxxxx xxxxxxRFGRRRLIVYNLVVVIPLQLCLPYLPSVELYITIQFLLGVSGLG LYLSSYVLS---------------------------------------TG YNEATxxxxxxxxxLIQLTACLKRSGVELVDGKWRTIT------------ ----------------------------------GLANPLSNPT------ -------------------------------------------------- ----------------AFVSIAGIAYLLPRWDYLNLAISLPALLIFGIWL AIPESPRWLMTQGKKEEVMEVIKTAARCNKRTLPTNIEKQLDQ------- ------------------------FMS-KSSNEEQAxxxxxxxTPNLRRN TLLLYVEWFTINLIYxALVLNTGNIGGNIYVTSAIL-------------- -------------------------------------------------- --GAVEYPAGALAILCMLKMGRRWPLSLSSIISGVACLLSLMVSPENPSG QWWVIMAAMIGKFCSAAASGIVFVTSLEIFPTVVRNVGLGTCQxxxxVAF LLTPFLWNL---------SDVQPWLPMSILGTSGIVGGxxxxxxPETSNR SFPHTLEDGEAISRxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxNIPGRADKVEMx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -- >Tce x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -IPESPRWLMTQGKKEEVMEVIKTAARCNKRTLPTNIEKQLDQ------- ------------------------FMS-RSSNEEQAxxxxxxxTPNLRRN TLLLYVEWFTINLxxxALVLNTGNIGGNIYVTSAILxxVEFSTxxxxxxx xxxxxxxxxxxxxxxxxRVLNSHRCNKEAETSGSIxxxxxxxxxxYCYSQ SQAMVEYPAVALAILCMLKMGRRWPLSLSSxxSGVACLLSLMVSPENPSG QWWVIMAAMIGKFCAAAASGIVFVTSLEIFPTVVRNVGLGTCQxxxxVAF LLTPFLWNL---------SDVQPWLPMSILGTSGIVGGxxxxxxPETSSR SFPHTLEDGEAISR------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xx >Tbi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------xxxxxxxxx xxxxxxRFGRRRLIVYNLVVVIPLQLCLPYLPSVELYITIQFLLGVSGLG LYLSSYVLS---------------------------------------TG YNEATIELMGGAEWLIQLTACLKRSGVELVDGRWRTIT------------ ----------------------------------GLANPLSNPT------ -------------------------------------------------- ----------------AFVSIAGIAYLLPRWDYLNLAISLPALLIFGIWM AIPESPRWLMTQGKKEEVMEVIKTAARCNKRTLPTNIEKQLDQ------- ------------------------VRD-K--------------------- -----xxx------------------------------------------ -------------------------------------------------- --------------------------------xGVxx------------- -----------------------------------------xx------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -x-----------------------------------------xxxxxxx xx >Tcm -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------MTQGKKEEVMEVIKTAARCNKRTLPTNIEKQLDQxxxxxxx xxxxxxxVYCESDALDYLTTEALCLMD-IxSNEEQAxxxxxxxTPNLRRN TLLLYVEWFTINLIYxALVLNTGNIGGDIYVTSAIL-------xxxxxxx xxxxxx---------------------------xxxxxxxxxx------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xx >Tsi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----DGKVTYDACKIWDRNYSSLTLGDLDLSxGHxLSAVPCTSWEFDVED SYGRTIISQWSLVxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------- ------RFGRRRLIVYNLVVVIPLQLCLPYLPSVELYIAIQFLLGVTGLG LYLSSYVLCKSPSAATxxxxLPQQLRPLISKSEIRIVExxxxxLGSTxTG YNESVxxxxxxxx---------------------RVITxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxVPRGDxxxxxxxxxxxxxxxPTxxxxxx xxxxxxxxxxxxxxxxRRELYRIGKVEIEEVNPHLRGGGVENHLGENHPx xxxxxxxxxxxxxxxxxxxxxxx--------------------------- AIPESPRWLMTQGKKEEVMEVIKTAARCNKRTLPTNIEKQLDQ------- ------------------------ITSxRSSNEEQAxxxxxxxTPNLRRN TLLLYVEWFTINLxxxALVLNTGNIGGDIYVTSAI--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -x