>Tge -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------MYVSAEGEFEV HKRGQILGTFGPGRVFGELAILYNSQRNASIRGKSHLVLVHFGFLSCLxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxLVHFCFLSRLxxxxxxxx xxxxxxxxxxxxxxxxxxxCFLSRLV---------------LLLATSGYG SLLLLVTSxx--LVTEALVWVLEREVFKQIMRISSIQRSQDNIKYLRSVP LLEHLSDKNLAEMSDLLRVKFFVPGTKIVEQDTNGNEFFIISGGSVKITK RIP----------------------------------------------- -------GSTEEEDLGTLVRGDFFGEQALLHQVLRQATITALSPGVECLV MEREPFEKxLGGIEGLKDKVYPPVISYQAxx------------------- ---------------EYQDIGLKDLLKVGTLGVGGFGRVELVQYKRDKKL TFAIKCLKKYYVVEQQQEDHAYNEKTVMLECAECPFxxRYVHRQVRSSPG TLIIRYVHRQASPSPGTFITRYVHxxxxxxxxxxxxxxxxRQVRSSPGTx VARYVRRQxxxxxxxLIA--------------R----------------- -------LYRTYRDTKYIYFLMEACLGGDVFTVLQKYKKFQDNTARFMIA CVVEALVFLHDRGFIYRDLKPENLLIDSTGYIKMTDFGFAKRIGTSGKTW TFAGTPEYVAPEIILNRGHDRSVDYWALGVLVYELLSGSPPFRGTDHLKT YGLILKGIESVKGFPKEITRDAKGLIRKLCRVVPTERLGYQKNGIADIKN HKWFTDFDWEALKQRRLPAPIVQPVKSNTDTSNFDKYEREKEIPPDEFSG WDKDF >Tms xVLQDYLGGVIVLMAIVASLVTATLLPGQVPPALVGLAVNYTLLVPIYLN WVVKFLADVEMYMNDVERVQQYATTPTEDYRTQGVSVPHSWPEKGDIVFE NVSLRYDSKREPVVTNLNLHIPPGQKVGICGRTGSGKSSLVMSLFHMVDV YEGSIEIDGIDITQVPLQVLRSRLSIIPQDVIMFSGTIRENLDPRHQYSD EDLWRSLEMAQLKDIVSSYQGCLDGEVREGGENLSAGERQLFCLARAILH DAACLIMDEATSSVDPGTEKALLAAAAKAFANKTVITIAFVKLATPLLEQ NMSPIPIHRLPTILECDRIVVLDEGRIAEDGSPAELMNKFKGFHWFHTLV LTVTITSFHRDMERASTERMYYQYISTVSRLTVAPSYPSTPPSDISESEE IWQQVTERERAKIKPFYIRAAVSSAMILDVAINHLVCNELKGEGGAFEFC VTNVAQSMVRGGLSSDPQAPRKFSNILALFVGGGAPKxxxxxxxSCFPSI FSDKETWTLESLSSDKRPGSFTKIDPDNRHDDNQSNNxxxxEKVxxxxHV SVFVNxxxSTCPKPPRIAVVDVIKRKASDVDIPFYQKDQS-------xxx -------------------------------------------------- -------------------------------------------------- -------------------------------------DHMYVSAEGEFEV HKRGQILGTFGPGRVFGELAILYNSQRNASIRGKSR-------------- -------------------------------------------xxxxxxx xxxxLVHLCFLSRLxxxxxxxxxxxxxxxxxxxxTSDSGTLPLLVTSGSG TLPLLVTSxxxxLVSEALVWVLEREVFKQIMRISSIQRSQDNIKYLRSVP LLEHLSDKNLAEMSDLLRVKFFVPGTKIVEQDTNGNEFFIISGGSVKITK RIP----------------------------------------------- -------GSTEEEDLGTLVRGDFFGEQALLHQVLRQATITALSPGVECL- ------------------------------xxxxxxxx------------ --xxxxxxxxxxYxxEYQDIGLKDLLKVGTLGVGGFGRVELVQYKRDKKL TFAIKCLKKYYVVEQQQEDHAYNEKTVMLECAECPF-------------- -------------------------------------------------- ----------------IA--------------R----------------- -------LYRTYRDTKYIYFLMEACLGGDVFTVLQKHKKFQDNTARFMVA CVVEALVFLHDRGFIYRDLKPENLLIDSTGYIKMTDFGFAKRIGTSGKTW TFAGTPEYVAPEIILNRGHDRSVDYWALGVLIYELLSGSPPFRGTDHLKT YGLILKGIESVKGFPKEITKEAKGLIRKLCRVVPTERLGYQKNGIVDIKN HKWFNDFDWEALKQRSLPAPIVQPVKSNTDTSNFDKYEREKEIPPDEISG WDKDF >Tsi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xxxxxxxxxx-----------------xGDHMYVSAEGEFEV HKRGQILGTFGPGRVFGELAILYNSQRNASIR------------------ -------------------------------------------------- -------------------------------------------------- ------------VVSEALVWVLEREVFKQIMRISSIQRSQDNIKYLRSVP LLEHLSDKNLAEMSDLLRVKFFVPGTKIVEQDTNGNEFFIISGGSVKITK RIP----------------------------------------------- -------GSTEEEDLGTLVRGDFFGEQALLHQVLRQATITALSPGVECLV MERE---------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------LYRTYRDTKYIYFLMEACLGGDVFTVLQKHKKFQDNTARFMVA CVVEALVFLHDRGFIYRDLKPENLLIDSTGYIKMTDFGFAKRIGTSGKTW TFAGTPEYVAPEIILNRGHDRSVDYWALGVLTYELLSGSPPFRGTDHLKT YGLILKGIESVKGFPKEITREAKGLIRKLCRVVPTERLGYQKNGIADIKN HKWFNDFDWEALKHRSLPAPIVQPVKSNTDTSNFDKYEREKEIPPDELSG WDKDF >Tcm -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------xxxxxxxxxx-----------------xGDHMYVSAEGEFEV HKRGQILGTFGPGRVFGELAILYNSQRNASIR------------------ -------------------------------------------------- -------------------------------------------------- ------------VVSEALVWVLEREVFKQIMRISSIQRSQDNIKYLRSVP LLEHLSDKNLAEMSDLLRVKFFVPGTKIVEQDTNGNEFFIISGGSVKITK RIP----------------------------------------------- -------GSTEEEDLGTLVRGDFFGEQALLHQVLRQATITALSPGVECLV MEREPFxxxxxxxEGLxxKVYxxVISYQAxx------------------- ---------------EYQDIGLKDLLKVGTLGVGGFGRVELVQYKRDKKL TFAIKCLKKYYVVEQQQEDHAYNEKTVMLECAECPF-------------- -------------------------------------------------- ----------------IA--------------xxxxxxxxxxxxxxxxxx xxxxxxxLYRTYRDTKYIYFLMEACLGGDVFTVLQKHKKFQDNTARFMVA CVVEALVFLHDRGFIYRDLKPENLLIDSTGYIKMTDFGFAKRIGTSGKTW TFAGTPEYVAPEIILNRGHDRSVDYWALGVLTYELLSGSPPFRGTDHLKT YGLILKGIESVKGFPKEITREAKGLIRKLCRVVPTERLGYQKNGITDIKN HKWFNDFDWEALKQRSLPAPIVQPVKSNTDTSNFDKYEREKEIPPDELSG WDKDF >Tps -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------xxxGCLPSF FSDKETWTLESLSSDKRPGSFTKIDPDNRHDDNQSNNxxxxEKVxxxxHV SVFVNxxxSTCPKPPRIAVVDVIKRKASDVDIPFYQKDQ----------R -------------------------------------------------- -----------SEDLIKSAIMANEFLNNLEPNQIDLVVGAMYHKELDxxx xxxxxDxx----------------------------GDHMYVSAEGEFEV HKRGQILGTFGPGRVFGELAILYNSQRNASIR------------------ -------------------------------------------------- -------------------------------------------------- ------------VVSEALVWVLEREVFKQIMRISSIQRSQDNIKYLRSVP LLEHLSDKNLAEMSDLLRVKFFVPGTKIVEQDTNGNEFFIISGGSVKITK RIP----------------------------------------------- -------GSTEEEDLGTLVRGDFFGEQALLHQVLRQATITALSPGVECLV MEREPFEKxLGGIEGLKDKVYPPVISYQAxx------------------- ---------------EYQDIGLKDLLKVGTLGVGGFGRVELVQYKRDKKL TFAIKCLKKYYVVEQQQQDHAYNEKTVMLECAECPF-------------- -------------------------------------------------- ----------------IA--------------R----------------- -------LYRTYRDTKYIYFLMEACLGGDVFTVLQKHKKFQDNTARFMVA CVVEALVFLHDRGFIYRDLKPENLLIDSTGYIKMTDFGFAKRIGTSGKTW TFAGTPEYVAPEIILNRGHDRSVDYWALGVLTYELLSGSPPFRGTDHLKT YGLILKGIESVKGFPKEITREAKGLIRKLCRVVPTERLGYQKNGIADIKN HKWFNDFDWEALKQRSLPAPIVQPVKSNTDTSNFDKYEREKEIPPDEFSG WDKDF >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------xxxSCFPSI FSDKETWTLEPLSSDKRPGSFTKIDPDNRHDDNQSSNxxxxEKVxxxxHV SVFVNxxxSTCPKPPRIAVVDVIKRKASDVDIPFYQKDQ----------R -------------------------------------------------- -----------SEDLIKSAIMANEFLNNLEPNQIDLVVGAMYHKELDxxx xxxxxDxx----------------------------GDHMYVSAEGEFEV HKRGQILGTFGPGRVFGELAILYNSQRNASIR------------------ -------------------------------------------------- -------------------------------------------------- ------------VVTEALVWVLEREVFKQIMRISSIQRSQDNIKYLRSVP LLEHLSDKNLAEMSDLLRVKFFVPGTKIVEQDTNGNEFFIISGGSVKITK RIP----------------------------------------------- -------GSTEEEDLGTLVRGDFFGEQALLHQVLRQATITALSPGVECLV MEREPFEKxLGGIEGLKDKVYPPVISYQAxx------------------- ---------------EYQDIGLKDLLKVGTLGVGGFGRVELVQYKRDKKL TFAIKCLKKYYVVEQQQEDHAYNEKTVMLECAECPF-------------- -------------------------------------------------- ----------------IA--------------R----------------- -------LYRTYRDTKYIYFLMEACLGGDVFTVLQKYKKFQDNTARFMIA CVVEALVFLHDRGFIYRDLKPENLLIDSTGYIKMTDFGFAKRIGTSGKTW TFAGTPEYVAPEIILNRGHDRSVDYWALGVLVYELLSGSPPFRGTDHLKT YGLILKGIESVKGFPKEITRDAKGLIRKLCRVVPTERLGYQKNGIADIKN HKWFTDFDWEALKQRSLPAPIVQPVKSNTDTSNFDKYEKEKEIPPDEFSG WDKDF >Tbi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------MYF-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------x--VVTEALVWVLEREVFKQIMRISSIQRSQDNIKYLRSVP LLEHLSDKNLAEMSDLLRVKFFVPGTKIVEQDTNGNEFFIISGGSVKITK RIP----------------------------------------------- ----------EEEDLGTLVRGDFFGEQALLHQVLRQATITALSPGVECLV MERE-----------------------------------xxxxxxxxxxx xxxxxxxxxxxxYxxEYQDIGLKDLLKVGTLGVGGFGRVELVQYKRDKKL TFAIKCLKKYYVVEQQQEDHAYNEKTVMLECAECPFxxxYVHRQVRSLPG TFIARYVHCQVRSLPGTFIARYVH-------------------------- ------RQxxxSxxxxxxxxxxRQVVFVIVTSR----------------- -------LYRTYRDTKYIYFLMEACLGGDVFTVLQKYKKFQDNTARFMIA CVVEALVFLHDRGFIYRDLKPENLLIDSTGYIKMTDFGFAKRIGTSGKTW TFAGTPEYVAPEIILNRGHDRSVDYWALGVLVYELLSGSPPFRGTDHLKT YGLILKGIESVKGFPKEITRDAKGLIRKLCRVVPTERLGYQKNGIADIKN HKWFTDFDWEALKQRSLPAPIVQPVKSNTDTSNFDKYEKEKEIPPDEFSG WDKDF >Tte -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------MYF-------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------x--VVTEALVWVLEREVFKQIMRISSIQRSQDNIKYLRSVP LLEHLSDKNLAEMSDLLRVKFFVPGTKIVEQDTNGNEFFIISGGSVKITK RIP----------------------------------------------- ----------EEEDLGTLVRGDFFGEQALLHQVLRQATITALSPGVECLV MEREPFEKxLGGIEGLNDKVYPPVISYQAKQ------ERxxxxxxxxxxx xxxxNxxxxxxxYxxEYQDIGLKDLLKVGTLGVGGFGRVELVQYKRDKKL TFAIKCLKKYYVVEQQQEDHAYNEKTVMLECAECPFxxRYVHCQVRSLPG TFIARYVHRQVRSSPGTFIARYVH-------------------------- ------xxxxxxxxxxxx--------------R----------------- -------LYRTYRDTKYIYFLMEACLGGDVFTVLQKYKKFQDNTARFMIA CVVEALVFLHDRGFIYRDLKPENLLIDSTGYIKMTDFGFAKRIGTSGKTW TFAGTPEYVAPEIILNRGHDRSVDYWALGVLVYELLSGSPPFRGTDHLKT YGLILKGIESVKGFPKEITRDAKGLIRKLCRVVPTERLGYQKNGIADIKN HKWFTDFDWEALKQRSLPAPIVQPVKSNTDTSNFDKYEKEKEIPPDEFSG WDKDF >Tce -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------MYVSAEGEFEV HKRGQILGTFGPGRVFGELAILYNSQRNASIRGKSRLV------------ ----------------------------------HFRFLSRLVLVHFFFL SRLVLVxxxxxxxxxxxxxxxx---------------------------- ---------x--LVSEALVWVLEREVFKQIMRISSIQRSQDNIKYLRSVP LLEHLSDKNLAAMSDLLRVKFFVPGTKIVEQDTNGNEFFIISGGSVKITK RIPxVASTCAEWFKNGHRIAGLILLEETLNNNKTLQKRRRLTHPILSNRL STGPVVARSTEEEDLGTLVRGDFFGEQALLHQVLRQATITALSPGVECL- ------------------------------xxxxxxxx------------ --xxxxxxxxxxYxxEYQDIGLKDLLKVGTLGVGGFGRVELVQYKRDKKL TFAIKCLKKYYVVEQQQEDHAYNEKTVMLECAECPF-------------- -------------------------------------------------- ----------------IA--------------R----------------- -------LYRTYRDTKYIYFLMEACLGGDVFTVLQKHKKFQDNTARFMVA CVVEALVFLHDRGFIYRDLKPENLLIDSTGYIKMTDFGFAKRIGTSGKTW TFAGTPEYVAPEIILNRGHDRSVDYWALGVLIYELLSGSPPFRGTDHLKT YGLILKGIESVKGFPKEITKEAKGLIRKLCRVVPTERLGYQKNGIVDIKN HKWFNDFDWEALKQRSLPAPIVQPVKSNTDTSNFDKYEREKEIPPDEISG WDKDF >Tdi x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------xxMxxGCLPSF FSDKETWTLESLSSDKRPGSFTKIDPDNRHDDNQSNNxxxxEKVxxxxHV SVFVNxxxSTCPKPPRIAVVDVIKRKASDVDIPFYQKDQRxKTPVSMFVR KSNKDENDVTKQASATAQERGIPLRPPDSSLTPYWCVTGIPRVYSDIKCS EFSYLFLESGLSEDLIKSAIMANEFLNNLEPNQIDLVVGAMYHKELDENT FIITExxx---------GKCVPGPPxxxxxxxxxxxGDHMYVSAEGEFEV HKRGQILGTFGPGRVFGELAILYNSQRNASIR------------------ -------------------------------------------------- -------------------------------------------------- ------------VVSEALVWVLEREVFKQIMRISSIQRSQDNIKYLRSVP LLEHLSDKNLAEMSDLLRVKFFVPGTKIVEQDTNGNEFFIISGGSVKITK RIP----------------------------------------------- -------GSTEEEDLGTLVRGDFFGEQALLHQVLRQATITALSPGVECLI MER----------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----