>Tge xxxxxxxxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------KSVIR ICFHERRLQYMEKEQMAAWQASRPGERILEVDVPLSYGLYDVSQDRHNLN TVKFLWDPTKEVGVYVKVNCISTEFTPKRHGGEKGVTFKIQVETYFNGED SGKHLHSAACQIKVFKLKGADRKHKQDRERILKRPLCEQDKFQPSYDCTV LND-------------------------------------------xxx- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------x >Tms --------xx---------xxxxxxxxxxxxxxxxx-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------E------------------- ----------------------------------CGGEGRMSAWQVDDIP DLDGSLSGLGVDLSGYTMNEGLLALPSLTIFKQEAPSPSSHNDNV----- ---PTNIELDSNAVNKNSQLHHILQHQSGQYGNSVVTTIPPQQQTQLANT VSQGVVSSSSPVTNMTISSVATSTTSPGQHNIDC-------------RFQ YVLAAATSTATKVNEETLTYLNQGQSYEIKLKKLGELSAYRGKILKSVIR ICFHERRLQYMEKEQMAAWQASRPGERILEVDVPLSYGLYDVSQDRHNLN TVKFLWDPTKEVGVYVKVNCISTEFTPKRHGGEKGVTFKIQVETYFNGED SGKHLHSAACQIKVFKLKGADRKHKQDRERILKRPLCEQDKFQPSYDCTV LND-------------------------------------------IPVE SQFFPSGAVTSxxxxxxxxxxxxxx-----xxxxxxxxx----------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------xxxxPVRADxxxxxPMLDGRGxxxxx >Tpa --------x----------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xxxxxxxxxxxxxxRFQ YVLAAATSTATKVNEETLTYLNQGQSYEIKLKKLGELSAYRGKILKSVIR ICFHERRLQYMEKEQMAAWQASRPGERILEVDVPLSYGLYDVSQDRHNLN TVKFLWDPTKEVGVYVKVNCISTEFTPKRHGGEKGVTFKIQVETYFNGED SGKHLHSAACQIKVFKLKGADRKHKQDRERILKRPLCEQDKFQPSYDCTV LND-------------------------------------------IPVE xxFFSSVAVTSxxxxxxxxxxxxxxxxxxxx------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------- >Tce --------xx-------------------------xxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxAEG----------------------------- --------NxxNPISPVSSSSNENVSNDAAEGLFPWGDELRFALDDVKVG YRTAVEGGRIALAAGTRKRKRWCDMDAAPPPQLAKIPSGVVGGQDMGFVD EEVMVEPILGDCGAGGKRDNNVVVRYKDTKDPxxxxxxNxxxx------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------KE------------------- ----------------------------------CGGEGRMSAWQVDDIP DLDGSLSGLGVDLSGYTMNEGLLALPSLTIFKQEAPSPSSHNDNV----- ---PTNIELDSNAVNKNSQLHHILQHQSGQYGNSVVTTIPPQQQTQLANT VSQGVVSSSSPVTNMTISSVATSTTSPGQHNIDC-------------RFQ YVLAAATSTATKVNEETLTYLNQGQSYEIKLKKLGELSAYRGKILKSVIR ICFHERRLQYMEKEQMAAWQASRPGERILEVDVPLSYGLYDVSQDRHNLN TVKFLWDPTKEVGVYVKVNCISTEFTPKRHGGEKGVTFKIQVETYFNGED SGKHLHSAACQIKVFKLKGADRKHKQDRERILKRPLCEQDKFQPSYDCTV LND-------------------------------------------IPVE SQFFPSGAVTSxxxxxxxxxxxxxxxx----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------- >Tps --------x----------------------------------------- --------------------x----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------xxxxx xxxPTNIELDSNDVNKNSQLHHILQHQSGQYGNSVVTTIPPQQQTQLDNT VSQGVVSSSSPVTNMTISSVATSTTSPGQHNIDC-------------RFQ YVLAAATSTATKVNEETLTYLNQGQSYEIKLKKLGELSAYRGKILKSVIR ICFHERRLQYMEKEQMAAWQASRPGERILEVDVPLSYGLYDVSQDRHNLN TVKFLWDPTKEVGVYVKVNCISTEFTPKRHGGEKGVTFKIQVETYFNGED SGKHLHSAACQIKVFKLKGADRKHKQDRERILKRPLCEQDKFQPSYDCTV LNDxxxxxxLGGDNLSTTDCNSNPYHPVIGSPVYFENDTLDHSITKIPVE SQFFSSVAVTSxxxxxxxxxxxxxxxx----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------- >Tdi --------M----------------------------------------- --------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxx---------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------E------------------- ----------------------------------CGGGGRMSAWQVDDIP DLDGSLSGLGVDLSGYTMNEGLLALPSLTIFKQEAPSPSSHNDNV----- ---PTNIELDSNDVNKNSQLHHILQHQSGQYGNSVVTTIPPQQQTQLDNT VSQGVVSSSSPVTNMTISSVATSTTSPGQHNIDC-------------RFQ YVLAAATSTATKVNEETLTYLNQGQSYEIKLKKLGELSAYRGKILKSVIR ICFHERRLQYMEKEQMAAWQASRPGERILEVDVPLSYGLYDVSQDRHNLN TVKFLWDPTKEVGVYVKVNCISTEFTPKRHGGEKGVTFKIQVETYFNGED SGKHLHSAACQIKVFKLKGADRKHKQDRERILKRPLCEQDKFQPSYDCTV LNDxxxxNHLGGDNLSTTDCNSxxxxxVIGSPVYFxxxxxDHSITKIPVE SQFFSSVAVTSxxxxxxxxxxxxxxxx----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------- >Tte --------xxxxxxxxxxxx---------------x-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------E------------------- ----------------------------------CVGEGRMSAWQVDDIP DLDGSLSGLGVDLSGYTMNEGLLALPSLTIFKQEAPSPSSH-DNV----- ---PTNIELDSNAANKNTQLHHILQHQSGQYGNSVVATILPQQQTQLDNT VSQGVVSSSSSVTNMTISSAATSTTSPGQHNIDC-------------RFQ YVLAAATSTATKVNEETLTYLNQGQSYEIKLKKLGELSAYRGKILKSVIR ICFHERRLQYMEKEQMAAWQASRPGERILEVDVPLSYGLYDVSQDRHNLN TVKFLWDPTKEVGVYVKVNCISTEFTPKRHGGEKGVTFKIQVETYFNGED SGKHLHSAACQIKVFKLKGADRKHKQDRERILKRPLCEQDKFQPSYDCTV LND----------------------------------------------- --------------------------------------xxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxIGLIGGEITCKEFWKRPKQHVITLPSVDM GCMVERGGMKxxxxxxxxxxx----------------------------- -------------------------------------------------- ----------------LEEERVLHMALSHVVRLGHEKGDSITFPSPESLD RIQLRSMNLPTDVDSLRGLIEKVFKRREETFNMENTYRQFVTAHVCKLAE EMRLDVVCLQEPYTLRGKVPHMPDAMRKLIPVVKGDTKVGNKPLNDRLQS LRARARITLRRKREFEDGLFQEKRKSWEKYVQVELQRGPWGVSFKIASGK LRSPxxxxxxxxxxxxxxxxxxxxxxLLxETLLPDxxxxxxxxxxxxxxx xxENDGx------------------------- >Tbi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------MSAWQVDDIP DLDGSLSGLGVDLSGYTMNEGLLALPSLTIFKQEAPSPSSHNDNV----- ---PTNIELDSNAANKNTQLHHILQHQSGQYGNSVVATILPQQQTQLDNT VSQGVVSSSSSVTNMTISSAATSTTSPGQHNIDC-------------RFQ YVLAAATSTATKVNEETLTYLNQGQSYEIKLKKLGELSAYRGKILKSVIR ICFHERRLQYMEKEQMAAWQASRPGERILEVDVPLSYGLYDVSQDRHNLN TVKFLWDPTKEVGVYVKVNCISTEFTPKRHGGEKGVTFKIQVETYFNGED SGKHLHSAACQIKVFKLKGADRKHKQDRERILKRPLCEQDKFQPSYDCTV LND----------------------------------------------- --------------------------------------xxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxIGWIxxxxxxxxxxxRPKQHxxxxxxxxM GCMVxxxxxxxxxxxxxxxxxCTMVLKWMYxxxxxxxxxxxxxxxxxERD NQGKPVLKDVVSRGSIIGLLGPNLRHEGRGDRLYTSLNPRDDPVTKFIRD YFGNVTEEGGKTFLTRLEEERVLHMALSHVVRLGHEKGDSITFPSAESLD RIQLRSMNLPTDVDSLRGLIEK---------------------------- -----------------------DAMRKLIPVVKGDTKVGNKPLNDRLQS LRARARITLRRKREFEDGLFQEKRKxxEKYVQVELQRGxxGVSFKIASGK LRPPxxxxxxxxxxxxxxxxxxxxxxLLxETLLPDxxxxxxxxxxxxxxx xxKNDGx------------------------- >Tsi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------xxxxxxxxLLYEIRPLxxS PVYxxxTLDAHAVRDCSANPAKFVSTVAxxxxxxCGGEGRMSAWQVDDIP DLDGSLSGLGVDLSGYTMNEGLLALPSLTIFKQEAPSPSSHNDNV----- ---PTNIELDSNDVNKNSQLHHILQHQSGQYGNSVVTTILPQQQTQLDNT VSQGVVSSSSSVANMTISSVATSTTSPGQHNIDC-------------RFQ YVLAAATSTATKVNEETLTYLNQGQSYEIKLKKLGELSAYRGKILKSVIR ICFHERRLQYMEKEQMAAWQASRPGERILEVDVPLSYGLYDVSQDRHNLN TVKFLWDPTKEVGVYVKVNCISTEFTPKRHGGEKGVTFKIQVETYFNGED SGKHLHSAACQIKVFKVRNS------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------- >Tcm --------Mx-------------------------xxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxAEG----------------------------- --------NxxNPISPVSSSSNENFSNDASEGIFPWGDELRFALDDVKVG YRTAVEGGRIALAAGTRKRKRWCDMDAAPPPQLAKIPSSVVGGQDMGYVD EEVMVEPILGDCGAGSKRDNNVVVRYKDTKDPxxxSNQNxxxxxGDRLAL HFxxxxxxxxxxxxYGWPTGSQCAACYPSGRRCKLVAAVKYASSHLPQAF SLVSWSQHHRGSLTFCARKTKPSIFDSWMGNIISNLLVLGGVGGGINELG GMHKTNTRLSIQEPEIxxxRGLSYHPFVQRKLGTLNQKTECVEPLVYxxx xxVxxxxxxxxLRGGRVGNxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx PLASxxxxxxxxxxxxRRRDxxxxxxxxxxE------------------- ----------------------------------CGGEGRMSAWQVDDIP DLDGSLSGLGVDLSGYTMNEGLLALPSLTIFKQEAPSPSSHNDNV----- ---PTNIELDSNDVNKNSQLHHILQHQSGQYGNSVVTTILPQQQTQLDNT VSQGVVSSSSSVANMTISSVATSTTSPGQHNIDC-------------RFQ YVLAAATSTATKVNEETLTYLNQGQSYEIKLKKLGELSAYRGKILKSVIR ICFHERRLQYMEKEQMAAWQASRPGERILEVDVPLSYGLYDVSQDRHNLN TVKFLWDPTKEVGVYVKVNCISTEFTPKRHGGEKGVTFKIQVETYFNGED SGKHLHSAACQIKVFKV--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- 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