>Tge xxxxxxxxxxxxxxxxxxxxx------------x---------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------x---------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------Y MWVMPSSSARCAQLPRAADKVPFYAALKKFRDYLNGIIADLDESEVVFSD SKLKNYFEPEVKEEPKDEHSCYAYGRLPSNGELTDLSNAVVKKDDQPPAK KKRGRPKKVKSDCPEVKKSGAEIQRKEPEHSDVPKKKRGRPKKIKTEDIM MSSNQHLEHK---------------------------------------- ------------------------------------------EISAAISS EHNLGSPSPTSPSIGPPDFEPPTSMPEDTSDDQQNSTRG----------- ------------------------------------------GSAPEYGA KRNMNQDVSSKSLSGLESLVDQIPSIAEGETPHGAVGNSNGEEQFDSPHI PT------------------------------------------------ --------------------------------------ISSLAASNYASM NTNVNSYSNLISAPHPMGSHMMGGTNSIGTPMFGGGMSGGIVERACSMGS SMGSLGSTVALPNHMNGMNMGSSSLPYPYRQYSHGASTYPGGPPGGFPYT -------------------------------------------------- ---------------------------------xxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxx >Tms x-------------------xxxxxxxxxxxx------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------KCLYLSGLTPEPMTADDDYKLLQVGIGFTNMVAR ATKGSADLTRKEIKE----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -GSQILLEKLQKFKPKIAVFNGKLIFEVFSGKKDFSFGKQPEFVDGTNTY MWVMPSSSARCAQLPRAADKVPFYAALKKFRDYLNGIIADLDESEVVFSD SKLKNYFEPEVKEEPKDEHSCYAYGRLPSNGELTDLSNAVVKKDDQPPAK KKRGRPKKVKSDCPEVKKSGAEIQRKEPEHCDVPKKKRGRPKKIKTEDIM MSSNQHLEHKSTPTPLPNCFSPPIHSPSNFNQQLNQQNLTNYNNQVSQSY SQNQSQSPSESHNYHQSPLQSQHYNQSPQPPSQPFTHSDLSSEISAAISS EHNLGSPSPTSPSIGPPDFEPPTSMPEDTSDDQQNPSRGVKNEMSPNNSQ KPNECCFSSPDPSNDASNMNYQNYRNYQTDSETNHSVIGYSQGSAPEYGA KRNMNQDVSSKSLSGLESLVDQIPSIAEGETPHGAVGNSNGEEQFDSPHI PTSQFNDESAYLGVYPNSSQYNNGSNSSNSSSYSPQFSSSSTNYSVSTSN SYSLHQSSASMNFSVTSLANSSASVNNEVSSQVSSSFSVSSLAASNYASM NTNVNSYSNLISAPHPMGSHMMGGTNSIGTPMFGGGMSGGIVERACSMGS SMGSLGSTVALPNHMNGMNMGSSSLPYPYRQYSHGASTYPGGPPGGFPYT PTHGLHVPSPNYPYPSPYSNSTYPQPSYLPNHVLDRIKQDRMDIGFGGF- -------------------------------------------------- -------------------------------------------------- ----------- >Tbi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- MWVMPSSSARCAQLPRAADKVPFYAALKKFRDYLNGIIADLDESEVVFSD SKLKNYFEPEVKEEPKDEHSCYAYGRLPSNGELTDLSNAVVKKDDQPPAK KKRGRPKKVKSDCPEVKKTGAEIQRKEPEHSDVPKKKRGRPKKIKTEDIM MSSNQHLEHKGTPTPLPNCFSPPIHSPSNFNQQLNQQNLTNYNNQVSQSY SQNQSQSPSESHNYHQSPLQSQHYNQSPQPPSQPFTHSDLSSEISAAISS EHNLGSPSPTSPSIGPPDFEPPTSMPEDTSDDQQNSTRGVKNEMSPNNSQ KPNECCFSSPDPSNDASNMNYQNYRNYQTDSETNHSVIGYSQGSAPEYGA KRNMNQDVSSKSLSGLESLVDQIPSIAEGETPHGAVGNSNGEEQFDSPHI PTSQFNDESAYLGVYPNSSQYNNGSNSSNSSSYSPQFSSSSTNYSVSTSN SYSLHQSSASMNFSVTSLANSSASVNNEVSSQVSSSFSVSSLAASNYASM NTNVNSYSNLISAPHPMGSHMMGGTNSIGTPMFGGGMSGGIVERACSMGS SMGSLGSTVALPNHMNGMNMGSSSLPYPYRQYSHGASTYPGGPPGGFPYT PTHGLHVPSPNYPYPSPYSNSTYPQPSYLPNHVLDRIKQDRMDIGFGGx- -------------------------------------------------- -------------------------------------------------- ----------- >Tte x------------------------------xxx---------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------x------------------------ -------------------------------------------------- ----------------KCLYLSGLTPEPMTADDDYKLLQVGIGFTNMVAR ATKGSADLTRKEIKE----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -GSQILLEKLQKFKPKIAVFNGKLIFEVFSGKKDFSFGKQPEFVDGTNTY MWVMPSSSARCAQLPRAADKVPFYAALKKFRDYLNGIIADLDESEVVFSD SKLKNYFEPEVKEEPKDEHSCYAYGRLPSNGELTDLSNAVVKKDDQPPAK KKRGRPKKVKSDCPEVKKTGAEIQRKEPEHSDVPKKKRGRPKKIKTEDIM MSSNQHLEHKGTPTPLPNCFSPPIHSPSNFNQQLNQQNLTNYNNQVSQSY SQNQSQSPSESHNYHQSPLQSQHYNQSPQPPSQPFTHSDLSSEISAAISS EHNLGSPSPTSPSIGPPDFEPPTSMPEDTSDDQQNSTRGVKNEMSPNNSQ KPNECCFSSPDPSNDASNMNYQNYRNYQTDSETNHSVIGYSQGSAPEYGA KRNMNQDVSSKSLSGLESLVDQIPSIAEGETPHGAVGNSNGEEQFDSPHI PTSQFNDESAYLGVYPNSSQYNNGSNSSNSSSYSPQFSSSSTNYSVSTSN SYSLHQSSASMNFSVTSLANSSASVNNEVSSQVSSSFSVSSLAASNYASM NTNVNSYSNLISAPHPMGSHMMGGTNSIGTPMFGGGMSGGIVERACSMGS SMGSLGSTVALPNHMNGMNMGSSSLPYPYRQYSHGASTYPGGPPGGFPYT PTHGLHVPSPNYPYPSPYSNSTYPQPSYLPNHVLDRIKQDRMDIGFGGF- -------------------------------------------------- -------------------------------------------------- ----------- >Tpa ---------------------------------xxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----xxxxxxxxxxxxxxxxxxxxxxxxxxxxx---------------- ------------xxxxxxxxxxxxxx------------------------ -------------------------------------------------- ----------------KCLYLSGLTPEPMTADDDYKLLQVGIGFTNMVAR ATKGSADLTRKEIKExSVSYRREPGRKGGSVGYRREPGGNRGSMGYRREP GEKGGSVGYHREPGEKGGSAGYRRELGGKGCSAGYRRELGGKGGSAGYRG EPGGREVQRVTAVNRAGREVRRVTVVNQVGREIQRVTAVNWAGREVQRAT VVNWAGREVRRVTAVNRAGKKVWRFTAVNLVGRELMMDNLDKKKYTQTLN xGSQILLEKLQKFKPKIAVFNGKLIFEVFSGKKDFSFGKQPEFVDGTNTY MWVMPSSSARCAQLPRAADKVPFYAALKKFRDYLNGIIADLDESEVVFSD SKLKNYFEPEVKEEPKDEHSCYAYGRLPSNGELTDLSNAVVKKDDQPPAK KKRGRPKKVKSDCPEVKKTGAEIQRKEPEHSDVPKKKRGRPKKIKTEDIM MSSNQHLEHKGTPTPLPNCFSPPIHSPSNFNQQLNQQNLTNYNNQVSQSY SQNQSQSPSESHNYHQSPLQSQHYNQSPQPPSQPFTHSDLSSEISAAISS EHNLGSPSPTSPSIGPPDFEPPTSMPEDTNDDQQNSTRGVKNEMSPNNSQ KPNECCFSSPDPSNDASNMNYQNYRNYQTDSETNHSVIGYSQGSAPEYGA KRNMNQDVSSKSLSGLESLVDQIPSIAEGETPHGAVGNSNGEEQFDSPHI PTSQFNDESAYLGVYPNSSQYNNGSNSSNSSSYSPQFSSSSTNYSVSTSN SYSLHQSSASMNFSVTSLANSSASVNNEVSSQVSSSFSVSSLAASNYASM NTNVNSYSNLISAPHPMGSHMMGGTNSIGTPMFGGGMSGGIVERACSMGS SMGSLGSTVALPNHMNGMNMGSSSLPYPYRQYSHGASTYPGGPPGGFPYT PTHGLHVPSPNYPYPSPYSNSTYPQPSYLPNHVLDRIKQDRMDIGFGGF- -------------------------------------------------- -------------------------------------------------- ----------- >Tdi ---------------------------------xx--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxxxxxxxxxxxxxxxxxxxxxx-- ----------------------------------xxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxKCLYLSGLTPEPMTADDDYKLLQVGIGFTNMVAR ATKASADLIRKEIKE----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -GSQILLEKLQKFKPKIAVFNGKLIFEVFSGKKDFSFGKQPEFVDGTNTY MWVMPSSSARCAQLPRAADKVPFYAALKKFRDYLNGIIADLDESEVVFSD SKLKNYFEPEVKEEPKDEHSCYAYGRLPSNGELTDLSNAVVKKDDQPPAK KKRGRPKKVKSDCPEVKKTGAEIQRKEPEHSDVPKKKRGRPKKIKTEDIM MSSNQHLEHKSTPTPLPNCFSPPIHSPSNFNQQLNQQNLTNYNNQVSQSY SQNQSQSPSESHNYHQSPLQSQHYNQSPQPPSQPFTHSDLSSEISAAISS EHNLGSPSPTSPSIGPPDFEPPTSMPEDTSDDQQNPSRGVKNEMSPNNSQ KPNECCFSSPDPSNDASNMNYQNYRNYQTDSETNHSVIGYSQGSAPEYGA KRNMNQDVSSKSLSGLESLVDQIPSIAEGETPHGAVGNSNGEEQFDSPHI PTSQFNDESAYLGVYPNSSQYNNGSNSSNSSSYSPQFSSSSTNYSVSTSN SYSLHQSSASMNFSVTSLANSSASVNNEVSSQVSSSFSVSSLAASNYASM NTNVNSYSNLISAPHPMGSHMMGGTNSIGTPMFGGGMSGGIVERACSMGS SMGSLGSTVALPNHMNGMNMGSSSLPYPYRQYSHGASTYPGGPPGGFPYT PTHGLHVPSPNYPYPSPYSNSTYPQPSYLPNHVLDRIKQDRMDIGFGGF- -------------------------------------------------- -------------------------------------------------- ----------- >Tcm ---------------------------------x---------xxx---- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------xxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--------------- ----------------KCLYLSGLTPEPMTADDDYKLLQVGIGFTNMVAR ATKGSADLTRKEIKE----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -GSQILLEKLQKFKPKIAVFNGKLIFEVFSGKKDFSFGKQPEFVDGTNTY MWVMPSSSARCAQLPRAADKVPFYAALKKFRDYLNGIIADLDESEVVFSD SKLKNYFEPEVKEEPKDEHSCYAYGRLPSNGELTDLSNAVVKKDDQPPAK KKRGRPKKVKSDSPEVKKTGAEIQRKEPEHSDVPKKKRGRPKKIKTEDIM MSSNQHLDHKSTPTPLPNCFSPPIHSPSNFNQQLNQQNLTNYNNQVSQSY SQNQSQSPSESHNYHQSPLQSQHYNQSPQPPSQPFTHSDLSSEISAAISS EHNLGSPSPTSPSIGPPDFEPPTSMPEDTSDDQQNPSRGVKNEMSPNNSQ KPNECCFSSPDPSNDASNMNYQNYRNYQTESETNHSVIGYSQGSAPEYGA KRNMNQDVSSKSLSGLESLVDQIPSIAEGETPHGAVGNSNGEEQFDSPHI PTSQFNDESAYLGVYPNSSQYNNGSNSSNSSSYSPQFSSSSTNYSVSTSN SYSLHQSSASMNFSVTSLANSSASVNNEVSSQVSSSFSVSSLAASNYASM NTNVNSYSNLISAPHPMGSHMMGGTNSIGTPMFGGGMSGGIVERACSMGS SMGSLGSTVALPNHMNGMNMGSSSLPYPYRQYSHGASTYPGGPPGGFPYT PTHGLHVPSPNYPYPSPYSNSTYPQPSYLPNHVLDRIKQDRMDIGFGGF- -------------------------------------------------- -------------------------------------------------- ----------- >Tce -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxDAENMMNSDLLMxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxIxxxxxxxxxxxxxxxxx xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------KCLYLSGLTPEPMTADDDYKLLQVGIGFTNMVAR ATKGSADLTRKEIKE----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -GSQILLEKLQKFKPKIAVFNGKLIFEVFSGKKDFSFGKQPEFVDGTNTY MWVMPSSSARCAQLPRAADKVPFYAALKKFRDYLNGIIADLDESEVVFSD SKLKNYFEPEVKEEPKDEHSCYAYGRLPSNGELTDLSNAVVKKDDQPPAK KKRGRPKKVKSDCPEVKKSGAEIQRKEPEHCDVPKKKRGRPKKIKTEDIM MSSNQHLEHKSTPTPLPNCFSPPIHSPSNFNQQLNQQNLTNYNNQVSQSY SQNQSQSPSESHNYHQSPLQSQHYNQSPQPPSQPFTHSDLSSEISAAISS EHNLGSPSPTSPSIGPPDFEPPTSMPEDTSDDQQNPSRGVKNEMSPNNSQ KPNECCFSSPDPSNDASNMNYQNYRNYQTDSETNHSVIGYSQGSAPEYGA KRNMNQDVSSKSLSGLESLVDQIPSIAEGETPHGAVGNSNGEEQFDSPHI PTSQFNDESAYLGVYPNSSQYNNGSNSSNSSSYSPQFSSSSTNYSVSTSN SYSLHQSSASMNFSVTSLANSSASVNNEVSSQVSSSFSVSSLAASNYASM NTNVNSYSNLISAPHPMGSHMMGGTNSIGTPMFGGGMSGGIVERACSMGS SMGSLGSTVALPNHMNGMNMGSSSLPYPYRQYSHGASTYPGGPPGGFPYT PTHGLHVPSPNYPYPSPYSNSTYPQPSYLPNHVLDRIKQDRMDIGFGGF- -------------------------------------------------- -------------------------------------------------- ----------- >Tsi ---------------------------------M---------------- ---------------------------------xxxxxxSAFSDGIVKQE PRDDGYETSGGLELRSQADNHKMMNHIHxxxxxGIKCEPLEDPYSFVDDD PTPIPQPRPPAVVLQNMPNKQGRKKKIPEGRSAFSDGIVKQEPRDDGYET SGGLELRSxxxxxxxxxxIHIAGSMGIKCEPLxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxDAENMMNSDLLMKKRxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxIIGINxxxxxxxxxxxxx xxxxxxxIPSTVWWINASxxLVxxxxxxxxxxxxxQEEQxIALQxxxxxx xxxxxxxxxxxxxxxxxxxxxITSTRPxxHLNPxxxxxxGQxxxxxxxxx xxxxxx-------------------------------------------- -------------------------------------------------- ----------------------------------x--------------- ----------------KCLYLSGLTPEPMTADDDYKLLQVGIGFTNMVAR ATKGSADLTRKEIKE----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -GSQILLEKLQKFKPKIAVFNGKLIFEVFSGKKDFSFGKQPEFVDGTNTY MWVMPSSSARCAQLPRAADKVPFYAALKKFRDYLNGIIADLDESEVVFSD SKLKNYFEPEVKEEPKDEHSCYAYGRLPSNGELTDLSNAVVKKDDQPPAK KKRGRPKKVKSDSPEVKKTGAEIQRKEPEHSDVPKKKRGRPKKIKTEDIM MSSNQHLDHKSTPTPLPNCFSPPIHSPSNFNQQLNQQNLTNYNNQVSQSY SQNQSQSPSESHNYHQSPLQSQHYNQSPQPPSQPFTHSDLSSEISAAISS EHNLGSPSPTSPSIGPPDFEPPTSMPEDTSDDQQNPSRGVKNEMSPNNSQ KPNECCFSSPDPSNDASNMNYQNYRNYQTESETNHSVIGYSQGSAPEYGA KRNMNQDVSSKSLSGLESLVDQIPSIAEGETPHGAVGNSNGEEQFDSPHI PTSQFNDESAYLGVYPNSSQYNNGSNSSNSSSYSPQFSSSSTNYSVSTSN SYSLHQSSASMNFSVTSLANSSASVNNEVSSQVSSSFSVSSLAASNYASM NTNVNSYSNLISAPHPMGSHMMGGTNSIGTPMFGGGMSGGIVERACSMGS SMGSLGSTVALPNHMNGMNMGSSSLPYPYRQYSHGASTYPGGPPGGFPYT PTHGLHVPSPNYPYPSPYSNSTYPQPSYLPNHVLDRIKQDRMDIGFGGF- -------------------------------------------------- -------------------------------------------------- ----------- >Tps ---------------------------------x---------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------xxxxxxxxxxxxxxxxx xxxxxxxxxxxxx------------------------------------- ----------------------------------xxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxKCLYLSGLTPEPMTADDDYKLLQVGIGFTNMVAR ATKGSADLIRKEIKE----------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -GSQILLEKLQKFKPKIAVFNGKLIFEVFSGKKDFSFGKQPEFVDGTNTY MWVMPSSSARCAQLPRAADKVPFYAALKKFRDYLNGIIADLDESEVVFSD SKLKNYFEPEVKEEPKDEHSCYAYGRLPSNGELTDLSNAVVKKDDQPPAK KKRGRPKKVKSDCPEVKKTGAEIQRKEPEHSDVPKKKRGRPKKIKTEDIM MSSNQHLEHKSTPTPLPNCFSPPIHSPSNFNQQLNQQNLTNYNNQVSQSY SQNQSQSPSESHNYHQSPLQSQHYNQSPQPPSQPFTHSDLSSEISAAISS EHNLGSPSPTSPSIGPPDFEPPTSMPEDTSDDQQNPSRGVKNEMSPNNSQ KPNECCFSSPDPSNDASNMNYQNYRNYQTDSETNHSVIGYSQGSAPEYGA KRNMNQDVSSKSLSGLESLVDQIPSIAEGETPHGAVGNSNGEEQFDSPHI PTSQFNDESAYLGVYPNSSQYNNGSNSSNSSSYSPQFSSSSTNYSVSTSN SYSLHQSSASMNFSVTSLANSSASVNNEVSSQVSSSFSVSSLAASNYASM NTNVNSYSNLISAPHPMGSHMMGGTNSIGTPMFGGGMSGGIVERACSMGS SMGSLGSTVALPNHMNGMNMGSSSLPYPYRQYSHGASTYPGGPP------ ----------------------------------------------xxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-------------- -------------------------------------------------- ----------x