>Tge -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------MADTS SSSSNATAPVADLSYRPQ-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------VSVHP TSAPQPPPDVYLYPPPPGLEVEHARMFTTDALKFVAQLITAFDRDVDQLY QKRLVRKCDLQGGSALPNFQRVPGDWKVAPLPRRLLNRHLDLGDVSPSNQ EHFTKALNADV--------------------------------------- --QGVQ-------------------------------------------- ---------------------VDFDDGHCPTWRNQISGLHNVYRAVHGLL PGVPSIHSAPILMLRPRAWNxxxQSRKRRLTTKGFVVLTILQPVAAEVGT Ixxxxxxxxxxx-----xKGKEVPGPLIDFGLLVFHNGKILAEQGCGPFF YLSKLEGANEARLWDDVFTWSERVLGITHGTIKACVLIENILSSFELDVI LFALKDHSLGLNCGIWDYAASIICKF------------------------ -------------------------------------------------- ----------------GDRKEFVLPDRSKYVNMERHFLKSYLRLVVQACH RRGAYATGGMAALLLPADGQKHT--------------------------- -------------------------------------------------- --------REAADVMRKVSEAKLSEIREGIDGFMVYDVGLVPVIN----- ------QLWQTYSPGLNQLSLTRDDLQVTSRDLLEMPQGGVTFAGLKHNI AVAILFVYHWLQGIGHFRYQGAVEDSATAEISRSQIWQWIRHGVSRTRHC ILKKTMMEDMDAVVTRSLVQSIATRFVSEQDRTPSRGEPQTKKPRLDTAL QLFLEIVSKRDFPEFITTYLNDSQT------------------------- ---------------------------FWACHRPIMAPYRLLSKQ >Tte -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------MNMADTS SSSSNATVPVADLSYRPQ-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------VSVHP TSAPQQPPDVYLQPPPPGLEVEHARMFTTDALKFVAQLITAFDRDVNQLY HKRLVRKCDLQGGSALPNFQRVPGDWKVAPLPRRLLNRHLDLGDVSPSNQ EHFTKALNADV--------------------------------------- --QGVQ-------------------------------------------- -------------------------------------------------- --x----------------------------------------------- ------------------NGKEVPGPLLDFGLLVFHNGKILAEQGCGPFF YLSKLEGANEAQLWDDVFTWSERVLGITHGTIKACVLIENILSSFELDGI LFALKDHSLGLNCGIWDYAASIICKF------------------------ -------------------------------------------------- ----------------GDRKEFVLPDRSKYVNMERHFLKSYLRLVVQACH RRGTHATGGMAALLLPADGQKHT--------------------------- -------------------------------------------------- --------REAADVMRKVSEAKLSEIRDGIDGFMVYDVGLVPVIN----- ------QLWQTYSPSLNQLSLTRDDLQVTSRDLLEMPQGGVTLAGLKHNI AVAILFVYHWLQGIGHFRYQGAVEDSATAEISRSQIWQWIRHG------- ----TMMEDMDAVVTRSLVQSIATRFVSEQDRNPSRGEPQTKKPRLDTAL QLFLEIVSKRDFPEFITTYLNDSQT------------------------- ---------------------------FWACHRPIMAPYRLLSKQ >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------MNMADTS SSSSNATVPVAFLSYRPQLxxxxxxxxxxxxxxxxx-------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------VSVHP TSAPQPPPDVYLDPPPPGLEVEHARMFTTDALKFVAQLITAFDRDVDQLY QMRLVRKCDLRGGSALPNFQRVPGDWKVAPLPRRLLNRHLDLGDVSPSNQ EHFTKALNADV--------------------------------------- --QGVQ-------------------------------------------- ---------------------VDFDDGHCPTWRNQISGLHNVYRAVHGLL PGx----------------------------------------------- ------------------NGKEVPGPLLDFGLLVFHNGKILAEQGCGPFF YLSKLEGANEARLWDDVFTWSERVLGITHGTIKACVLIENILSSFELDGI LFALKDHSLGLNCGIWDYAASIICKF------------------------ -------------------------------------------------- ----------------GDRKEFVLPDRSKYVNMERHFLKSYLRLVVQSCH RRGAHATGGMAALLLPADGQKHTS--------------xxxxxxxxVLVx xxxxxxxLGH----------------------xxYEDWASPACDVAMPVx xxxxxxxxREAADVMRRVSEAKLSEIREGIDGFMVYDVGLVPVIN----- ------QLWQTYSPGLNQLSLTRDDLQVTSRDLLEMPQGGVTLAGLKHNI AVAILFVYHWLQGIGHFRYQGAVEDSATAEISRSQIWQWIRHG------- ----TMMEDMDAVVTRPLVQSIATRFVSEQDRTPSRGEPQKRKPRLDTAL QLFLEIVSKRDFPEFITTYLNDSQT------------------------- ---------------------------FWACHRPIMAPYRLLSKQ >Tbi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------M------ -----------------------------------xxxxxxxDPLRGRPN YSHHCVKELLCLGQLPTFQLNDKINSVRVQNQSRRNREIxxxxxxMDRAR LxxxxxxxxxxxxxKYExxxxxxDGQERxxIITHRIGVTMSTASHLLIGG ALTLMAQAIMAMSHDNIFADKLSRQGRVRAHWVLQAFAAIFIFGGFLVIV INxxxxxxxxxxTIxxxVGLIAVILVGLxxxxxxxxxxxxxxxxxVSVHP TSAPQQPPDVYLQPPPPGLEVEHARMFTTDALKFVAQLITAFDRDVNQLY HKRLVRKCDLQGGSALPNFQRVPGDWKVAPLPRRLLNRHLDLGDVSPSNQ EHFTKALNADVxxxxGExMAFMTYxxxxGSDxPMAFMTYKxxRWAFMTYK xx------------------------------------------------ ---------------------VDFDDGHCPTWGNQISGLHNVYRA----- --x----------------------------------------------- ------------------NGKEVPGPLLDFGLLVFHNGKILAEQGCGPFF YLSKLEGANEAQLWDDVFTWSERVLGITHGTIKACVLIENILSSFELDGI LFALKDHSLGLNCGIWDYAASIICKF------------------------ -------------------------------------------------- ----------------GDRKEFVLPDRSKYVNMERHFLKSYLRLVVQACH RRGTHATGGMAALLLPADGQKHT--------------------------- -------------------------------------------------- --------REAADVMRKVSEAKLSEIRDGIDGFMVYDVGLVPVIN----- ------QLWQTYSPSLNQLSLTRDDLQVTSRDLLEMPQGGVTLAGLKHNI AVAILFVYHWLQGIGHFRYQGAVEDSATAEISRSQIWQWIRHG------- ----TMMEDMDAVVTRSLVQSIATRFVSEQDRNPSRGEPQTKKPRLDTAL QLFLEIVSKRDFPEFITTYLNDSQT------------------------- ---------------------------FWACHRPIMAPYRLLSKQ >Tms -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------MNMADTS SSSNDTTDPVAFLGYRTQ-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------VSVHP TSAPQPPPDVYLDPPPPGLEVEYARIFTTGALKFVAQLITAFYRDIDQLY QKRLVRKCDLQGGSVLPNFQKVPGDWKVAPLPRRLLNRHLDLGDVSPSNQ EHFTKALNADV--------------------------------------- --QGVQ-------------------------------------------- -------------------------------------------------- --x----------------------------------------------- ------------------NGKEVPGPLLDFGLLVFHNGKILAEQGCGPFF YLSKLEGANEAQLWDDVFTWSERMLGITHGTIKACVLIENILSSFELDGI LFALKDHSLGLNCGIWDYAASIICKF------------------------ -------------------------------------------------- ----------------GDRKEFVLPDRSKYVNMERHFLKSYLRLVVQTCH RRGAHATGGMAALLLPADGQKHTRYTLEGxxxxxxxxxx----------- -------------------------------------------------- --------REAADVMRKVSEAKLNEIREGIDGFMVYDTGLVPVIN----- ------QLWQTYSPSLNQLSLTRDDLQVTSQDLLEMPQGGVTLAGLKHNI AVGILFVYHWLQGIGHFRYQGAVEDSATAEISRSQIWQWIRHG------- ----TMIEDMDAVVTRSLVQSIATRFVSEQNRTPSRGDQQT-xPRLDTAL QLFLEIVSKRDFPEFITTYLNDSHT------------------------- ---------------------------FWACHRPIMAPYRLLSKQ >Tce -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------MNMADTS SSSNDTTDPVAFLGYRTQ-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------VSIHP TSAPQPPPDVYLDPPPPGLEVEYARIFTTGALKFVAQLITAFYRDIDQLY QKRLVRKCDLQGGSVLPNFQKVPGDWKVAPLPRRLLNRHLDLGDVSPSNQ EHFTKALNADV--------------------------------------- --QGVx-------------------------------------------- -------------------------------------------------- --x----------------------------------------------- ------------------NGKEVPGPLLDFGLLVFHNGKILAEQGCGPFF YLSKLEGANEAQLWDDVFTWSERMLGITHGTIKACVLIENILSSFELDGI LFALKDHSLGLNCGIWDYAASIICKF------------------------ -------------------------------------------------- ----------------GDRKEFVLPDRSKYVNMERHFLKSYLRLVVQTCH RRGAHATGGMAALLLPADGQKHTRYTLEGxxxRFYRIRI----------- -------------------------------------------------- --------REAADVMRKVSEAKLNEIREGIDGFMVYDIGLVPVIN----- ------QLWQTYSPSLNQLSLTRDDLQVTSQDLLEMPQGGVTLAGLKHNI AVGILFVYHWLQGIGHFRYQGAVEDSATAEISRSQIWQWIRHGVSLTRQR ILKKTMMEDMDAVVTRSLVQSIATRFVSEQNRTPSRGDQQT-xPRLDTAL QLFLEIVSKRDFPEFITTYLNDSHTxxxxxxxxxxxxxxxxxxxxFIVLT TCHPLSANVGTIFTNIQQPPDRCGxxx------------------ >Tsi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------MNMADTS SSSNNTTDPVxxLxxxxx-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------VSVHP TSTPQPPPDVYLEPPPPGLELEHARIFTSDALKFVAQLITAFVRDIDQLY QKRLVRKCDLQGGSLLPNFQKVPGDWKVAPLPRRLLNRHLDLGDVSPSNQ KHFTKALNADV--------------------------------------- --QGVx-------------------------------------------- ---------------------VDFDDGHCPTWRNQISGLHNVYRAxHGLL PGVPRIRSVPILMLRPRAWNx----------------------------- -----------VEHHLxxNGREVPGPLFDFGLLVFHNGKILSEQGCGPFF YLSKLEGANEAQLWDDVFTWSERMLGITHGTIKACVLIENILSSFELDGI LFALKDHSLGLNCGIWDYAASIICKFGIREIIFICSVPAFTWRVSGKPFR KKPPSVTRAILNIDLPVIGSLVYFESSVLNNGATEVSCELSVSTKVVTGL LCHILRTFGQCLAHLSGDRKEFVLPDRSKYVNMERHFLKSYLRLVVQACH RRGAHATGGMAALLLPTDGQKHT--------------------------- -------------------------------------------------- --------REAADVMRKVSEAKLSEIREGIDGFMVYDVGLVPVINxIVNP RFMDPIQLWQTHSPSLNQLSLTRDDLQVTSHDLLEMPQGGVTLAGLKHNI AVGILFVYHWLQGIGHFRYQGAVEDSATAEISRSQIWQWIRHGVSQTRRR ILKKTMMEDMDAVVTRSLVQSIATRFVSEQNRTPSRGDQQTKPPRLDTAL QMFLEIVSKRDFPEFITTYLNDSHT------------------------- ---------------------------FWACHRPMTAPYRLLSxx >Tcm -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------MAALLLPTDGQKHT--------------------------- -------------------------------------------------- --------REAADVMRKVSEAKLSEIREGIDGFMVYDVGLVPVINxIVNP RFMDPIQLWQTHSPSLNQLSLTRDDLQVTSHDLLEMPQGGVTLAGLKHNI AVGILFVYHWLQGIGHFRYQGAVEDSATAEISRSQIWQWIRHG------- ----TMMEDMDAVVTRSLVQSIATRFVSEQNRTPSRGDQQTKPPRLDTAL QMFLEIVSKRDFPEFITTYLNDSHT------------------------- ---------------------------FWACHRPMTAPYRLLSKQ >Tps -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------MADTS SSSNNTTDPVAVLGYRP--------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------------QLY QKRLVRKCDLQGGSLLPNFQKVPGDWKVAPLPRRLLNRHLDLGDVSPSNQ EHFTNALNADV--------------------------------------- --QGVQ-------------------------------------------- ---------------------VDFDDGHCPTWRNQISGLHNVYRAVHGLL PGVPSIHSVPILMLRPRAWNx----------------------------- -----------VEHHLxxNGKEVPGPLLDFGLLVFHNGKILADQGCGPFF YLSKLEGANEAQLWDDVFTWSERMLGITHGTIKACVLIENILSSFELDGI LFALKDHSLGLNCGIWDYAASIICKF------------------------ -------------------------------------------------- ----------------GDRKEFVLPDRSKYVNMERHFLKSYLRLVVQACH RRGAHATGGMAALLLPADGHKHT--------------------------- -------------------------------------------------- --------REAADVMRKVSEAKLSEIREGIDGFMVYDVGLVPVIN----- ------QLWQTHSPSLNQLSLTRDDLQVTSHELLEMPQGGVTLAGLKHNI AVGILFVYHWLQGIGHFRYQGAVEDSATAEISRSQIWQWIRHGxxxxxxx xxxx---------------------------------------------- -------------------------------------------------- --------------------------------------------- >Tdi xxxNSVTVQNQSRRNREIxxxxxxMDRARLxxxxxxxxxxxxxNYGxxxx xxDGQERxxIITHRIGALTLMAQAIMAMSHDNIFADKLSRQGRVRAHWVL QAFAAIFIFAGFLVIVVNKNxxxxxxxxTIxxxVGLISVILVGLxxxxxx xxxxxxxxxxxVRPAVMKLVHNILGIVTFSLGVICIILGLFSKWFSDNGG YAAQVICTVVVALAGVLTLESAVKSAYASHCISHRLPGTKPNRLSHKRNF PAARFRSTNFSCITKFSRDWFGTTACISGEIDARKTRNKFKTRTLGFKQH LQDVSGDISPASLLNEKEVALEFKPNGKVTIDHGKSKVRHTLQMxMADTS SSSNNTTDPVAVLGYRPQ-------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------------------------VSVHP TSTPQPPPDVYLEPPPPGLELEHARIFTSDALKFVAQLITAFDRDIDQLY QKRLVRKCDLQGGSLLPNFQKVPGDWKVAPLPRRLLNRHLDLGDVSPSNQ EHFTKALNADV--------------------------------------- --QGVQMGFHDVxxxxxxxxDVxxxxxGFHDVQxxQMGFHDVQxxQxxxx xxxxxxxxxxxxxxxxxxxHxVDFDDGHCPTWRNQISGLYNVYRAxHGLL PGVPSIRSVPILMLRPRAWN------------------------------ ----------------xxNGKEVPGPLLDFGLLVFHNGKILAEQGCGPFF YLSKLEGANEAQLWDDVFTWSERMLGITHGTIKACVLIENILSSFEMDGI LFALKDHSLGLNCGIWDYAASIICKF------------------------ ----------------------------------EVSCELSVTTKVVTGL LNHILRTFGQCLTHLSGDRKEFVLPDRSKYVNMERHFLKSYLRLVVQACH RRGAHATGGMAALLLPADGHKHTRYTLEG----xxxIRI----------- -------VGHELTTVSLLTSKMSAxxxxxxxxx----------------- --------SEAADVMRRVSEAKLSEIREGIDGFMVYDVGLVPVIN----- ---------QTHSPSLNQLSLTRDDLQVTSHELLEMPQGGVTLAGLKHNI AVGILFVNHWLQGIGHFRYQGAVEDSATAEISRSQIWQWIRHG------- ----TMMEDMDAVVTRSLVQSIATRFVSEQNRTPSRGDQQTKPRYLDTAL QMFLEIVSKRDFPEFITTYLNDSHT------------------------- ---------------------------FWACHRPMTAPHRLLSKQ