>Tms xGDNGVASTSVRRDLQGKENRNSFKRIVDAPKHCSRKRKRDVVSHCQRHS VDKHHSSSTSTGTDKRHELSTKRRHKLSTGKKHAGDLKKEKMSKKEEKRQ HKTLVKKHAVYNKEVHDAENSLRKRLQNxLxLEVPLLQQENQKACLESME LASQDGEFDGQDGELGTM----ESQEVELESQEGELGSQELVLEPQVVEL SDSDEPAGTQYIAEECLELAPDQNIESEEPAIDSEIVEIPVVKIPIEVID ILSSPESCSDIELDQTSFEKIPCNDGETTAENVVDHEDISHKDTGGNILE --------KTKTTVINTAEEDEVLQLRLIALRSAVMKKHLERKKRGIRIR TKRQQARETLIYPPDIPLPPTNREQGDTLPSNGP---HQSDSSVNTEPDE ITTIVDMELADTDDEKDMSKPTTDQEAIH--------------------- -------------------------------------------------- -------------------------------------------------- ---------------------WNSNRGEPTMYSNEPIWEPDCPRYNAGPP FNNDGMLGPHDYENTFYRTGMHPHEYYQDPGSPHIPAQFYPDSSDVYSKC PPIPTGEPGELVGLSTNEEHLHKMPAIHIAKSTAENSAITKKSVVDYVKE CLKDILETTKKHKSNAIKVSTPxSHDGHVLTTNENGASPINAGEFIGPSS PVNVGSFSPINVGASSQVKKDDDSLSTKMSSYIDRTSLVLSGSPEHVKPI SSKYPFNYVQPSSPKQPNNTPSSILSEIQKQQDDDDDELLLRERLLMALK CKNAKSLVDPLKAAPRVNSMLADTTSMxxDISSTNTDTSINSADTKLAST VINHTQAESLQSAYSPTQTVESLQRNFTYKRKLPPKCQQPTSGVYLARKR VNAARLTTKGGPALSLQVTVPTKEPPEPRKRFVICLGEESDSGTEEDPEM SHEFERSVEVFLRQAREKQEAQTIQGTTPISIRSMPLSQQQEYRRLRDQI AKLEESNHQQRLRLASKNIKAQLPLSPSKKESSSVPLHNTVLASSHNLKQ INLPNDRTRT---------------------------------------- -------------------------------------------------- RGRGTRTISKPYFTNKFTGRRVSASKGLVVTIPGAPPNAGRSTSSLLVQE VSSSLDLSDVSDVAEKNGTCNESWIVTNTNKDEVLK-CHDGHSSSEDCVS SINKNKEATKEETxDEMDVDSILATNVVKSSKLATCKDGLAKSEINERS- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------KEHLEDLQTQLTDVEQKLLKQRYAVLNDMTVTLDL LNQLDQERSNKDILSEEVKQLRAQLLSAEGRLAQQRKVLQTVRTQTSESY NRVVEGKTACLGLSRRCLMLGISLRGKQYKVPTAAAKIMVLKLHQLAKLS QRLKRRSGGEENVITREP----PSMSLAQKQV------------------ ------------------------------------------ENETQNLS STIHETRLVSCSRTKQNxQTDVSISCSDKTQxxQLLDEQGLVGDKVVLNA NSFEYIPFSSKNSADDEELTYEEPTTLSLSSNCLALEHTSESSASGTIYR DKVLGLDIDPSRTTETSWTLPADWIHT----------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxxxxxExxxxxTxxxx---------- ------------------------- >Tbi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------MDTSEEDEVLQLRLIALRSAVMKKHLERKKRGIRIR TKRQQARETLIYPPDIPLPPTNREQGDKVPSNGPDLSHQSDSSGNTEPDE ITTIVDMELADTDDEKDMSKPTTxxEAIH--------------------- -------------------------------------------------- -------------------------------------------------- ---------------------WNSNRGEPTIYSNEPIWEPDFPRYNAGPP YNNDGMLVPHDxxxxxxxxGMHPHEYYQDPGSPHIPAQFYxxxxxxxxxx PPIPIGEPGELxxxxxxEENLHKIPAVQTATKTAENSAITKKSVVDYVKE CLKDILETTKKHKSNAKKVSTP-SHGGGVLTTNENGASPINAREFxGPSS PVNVGSFSPINVGASSQVKKGNDSLSIKMSSYIDKTSLVLxxxxxxxxxI SSEYPSNYLQPSSPKQPNNSPSSILSEIQKQQDDDDDELLLRERLLMALK CKNAKSLVDPLKAAARVDSVLANTTS---QLGSKNTDTAPNCADTKLAST VINHTQAEPLQTAYSQTQTVESPQRNFTYKRRFPAKCQQPTSGLHLARKR VNAARLTTKGGPALSLQVTVPTKEPPEPRKRFVICLGEESDSGAEEDPEM SHEFERSVEVFLRQAREKQEAQTIQGTTPISIRSMPLSQQQEYRRLRDQI AKLEESNHQQRLRLASKNIKAQLPLSPSKKVGSSVPLHNMVVARSRNLKQ IILPNDRTRTRFDKLRSNAPMLSxELGRPFSNRTSTKNTAQTLVNKEASS SSKQATEFLPVSVKTSSCISAPRPSVKTTSPSIRxTTLSKPGRTYTYFNA RGRGTRTISKPYFTNKFARRRVSASKGLVVTIPGAPPNAGGSTSSLLMQE VSPSLKLSDVSDVAEKNEICNVSWSVTNTHKDEVMKKYHDGHSVSEDCVS SINRNREAAKEET------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------KEYLEDLQTQLTDVEHKLLNQRYAVLDDMTVTLDL LNQLEQERSSKDILSEEVKRLRAQLLSAEGRLAQQRKVVQTVRTQTSESY HRVVEGKTACLGLSRR--------------VPTAAAKIMVLKLHQLAKLS QRLKRKSGGDENVTTREPLVLSPSVCLAQKQV------------------ ------------------------------------------ESETQNLS STIHETHLVSCTPSK---QTDESISCSEKTHx-LLLDEQGLVGDKVMLNA NSFEYIPFSSKNSTDDEELTYEEPATLSLSSNCLALEHPSESSASWTIYR DKVLGLDIDPTRTTETSWTLPADRIHT----------------------- -------------------------------------------------- -------------------------------------------------- ---SPDWSVKIDPLHPLCPYDLRGACRDVECQFQHITWLH---------- ------------------------- >Tte -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------VVEL SDSDEPAGIQYIAEECLELVPDQNIESEEPSIDSEIVEIPVVKIPIEVID ILSSPESCSDIEQDQTSFEENP-------AEKVEDHEDIGHKDTGGNILD KPITGTCEKTKTNEMDTTEEDEVLQLRLIALRSAVMKKHLERKKRGIRIR TKRQQARETLIYPPDIPLPPTNREQGDKVPSNGPDLSHQSDSSGNTEPDE ITTIVDMELADTDDEKDMSKPTTYQEAIH--------------------- -------------------------------------------------- -------------------------------------------------- ---------------------WNSNRGEPTIYSNEPIWEPDFPRYNAGPP YNNDGMLVPHDYENTYYRTGMHPHEYYQDPGSPHIPAQFYPASSDVYSEC PPIPIGEPGELVGLSINEENLHKMPAVQTATKTAENSAITKKSVVDYVKE CLKDILETTKKHKSNAKKVSTP-SHGGGVLTSNENGASPINAREFIGPSS PVNVGSFSPINVGASSQVKKGNDSLSIKMSSYIDKTSLVLSESPEHVRPI SSEYPSNYLQPSSPKQPNNSPSSILSEIQKQQDDDDDELLLRERLLMALK CKNAKSLVDPLKAAARVDSVLANTTS---QLGSKNTDTALNCADTKLAST VINHTQAEPLQTAYSQTQTVESPQRNFTYKRRFPAKCQQPTSGLHLARKR INAARLTTKGGPALSLQVTVPTKEPPEPQKRFVICLGEESDSGAEEDPEM SHEFERSVEVFLRQAREKQEAQTIQGTTPISIRSMPLSQQQEYRRLRDQI AKLEESNHQQRLRLASKNIKAQLPLSPSKKVGSSVPLHNMVVARSRNLKQ IILPNDRTRTRFDKLRSNAPMLSSELGRPFSNRTSTKNTAQTLVNKEASS SSKQATEFLPVSVKTSSCISATRPSVKTTSPSIRxTTLSKPGRTYTYFNA RGRGTRTISKPYFTNKFARRRVSASKGLVVTIPGAPPNAGGSTSSLLMQE VSPSLKLSDVSDAAEKNEICNVSWSVTNTHKDEVMKKYHDGHSVSEDCVS SINRNREAAKEET------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------KEHLEDLQTQLTDVEHKLLNQRYAVLDDMTVTLDL LNQLEQERSSKDILSEEVKRLRAQLLSAEGRLAQQRKVVQTVRTQTSESY HRVVEGKTACLGLSRRCLMLGISLRGKQYKVPTAAAKIMVLKLHQLAKLS QRLKRKSGGDENVTTREPPVLSPSVCLAQKQVxxxxxxxxxxxxxxxxxx Exxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------- ---------------------------------------GLVGDKVMLNA NSFEYIPFSSKNSTDDEELTYEEPATLSLSSNCLALEHPSESSASWTIYR DKVLGLDIDPARTTKTSWTLPADWIHT----------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxxxxxxxxxxxxxxxxxxExxxxxIxxxx---------- ------------------------- >Tsi x------------------------------------------------- -------------------------------------------------- -----------------------------LxLEVPLLQQENQKACLESVE LASQEGEFDGQDGELGTMEGELESQEVELESQEKKGKSQELVLEPQVVEL SDSDEPAGTQYSAEECLELAPDQNIESEEPAIDSEIVEIPVVKIPIEVID ILSSPESCSDIELDQTSFEEIPCKNGETTPENVVDHEDISHKDTGGNILD KPLSGTCKKTKTTVINTTEEDEVLQLRLIALRSAVMKKHLERKKRGIRIR TKRQQARETLIYPPDIPLPPTNREQGDKLPSNGP---HQSDSSGNTEPDE ITTIVDMELADTDDEKDMSKPTTDQEAIH--------------------- -------------------------------------------------- -------------------------------------------------- ---------------------WNSNIGEPTMYSNEPIWESDCPRYNAGPP FNNDGMLVPHDYENTFYRTGMRPHEYYQDPGSPHIPAQFYPASSDVYSKC PPIPTGEPGELVALSINEEHLHKMPAIQTATSTAENSAITKKSVVDYVKE CLKDILETTKKHKSNAKKVSTP-SHDGHVLTTNENGASPINAGEFIDPSS PV--------NVGASSQVKKDDDSLSTKMSSYIDRTSLVLSGSPEHVKPI SSKYPLNYLQPSSPKQPNNTPSSILSEIQKQQ-DDDDELLLRERLLMALK CKNPKSLVDPLKAATRVDSMLADTTSIxxDIGSTNTDTAIPCADTKLVST VINHTQAVSIQSAYSPTQTVESLQRNFTYKRRLPPKCQQPPSGVHLARKR VNAARLTTKGGPALSLQVTVPTKEPPEPRKRFVICLGEESDSGTEEDPEM SHEFERSVEVFLRQAREKQEAQTIQGTTPISIRSMPLSQQQEYRRLRDQI AKLEESNHQQRLRLASKNIKAQLPLSPNKKVGSSVPLQNMVIASSHTLKQ INLPNDKTRTKFDKLR---------------------------------- ----------------SCVSATRPSIRTTS-----TTLSKPGRTYTYFNA RGRGTRTISKPYFTNKFAGRRVSASKGLVVTIPGAPPNAGRSKSSLLVQE VSPSLKLSDVSDVAEKNGTCNESWSVTNTNKDEVLKMCHDGHSSSEDCVS SINKNREAAKEETxDEMDVDSILATNVVKSSNLATCKDGLAKSEINERSS VTFNVKSLTNQGTKNDGHSKINTNLIVDSKLISKINFKTSSDKIVAKASL DINLENNIERTSSPNHFEINVDSIHGITDNETTLRMNEVSEITNSLDCSS NMKLNIIGVEIGSENGLKFDTNLSKSTKNHSSFKLESGSKNTCMDSDLGI NDETLSERNNMEFLKEQHLEDLQTQLTDVEQKLLKQRYAVLDDMTVTLDL LNQLEQERSNKDILSEEVKRLRAQLLSAEGRLAQQRKVLQTVRTQTSESY HRVVEGKTACLGLSRQCLMLGISLRGKQYKVPTAAAKIMILKLHQLAKLS QRLKRRSGGEENVITREPPVISPSVCLAQKQV------------------ ------------------------------------------ESETQNLS STIHETRLVSCTRAK---QTDVSISCSEKTQxxLLLDEQGLVGDKVMLNA NSFEYIPFSSKNSANDEELTYEEPATFSLSSNCLALEHPSESSASGTIYR DKVLGLDIDPSRTSETSWTLPADWIHTxxxxxxxxxxxxFEELVExxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxVSISQAMQVRxxxxxxxxxxxxxx xxSRR-------------------------------KxxxxxxxxVLRxG xxxxx----------------------------------xxxxxxxxHID NGPSSSAFWTLCSMLEQxxxxxxxx >Tcm x------------------------------------------------- -------------------------------------------------- -----------------------------LxLEVPLLQQENQKACLESVE LASQEGEFDGQDGELGTMEGELESQEVELESQEKKGKSQELVLEPQVVEL SDSDEPAGTQYSAEECLELAPDQNIESEEPAIDSEIVEIPVVKIPIEVID ILSSPESCSDIELDQTSFEEIPCKNGETTPENVVDHEDISHKDTGGNILD KPLSGTCKKTKTTVINTTEEDEVLQLRLIALRSAVMKKHLERKKRGIRIR TKRQQARETLIYPPDIPLPPTNREQGDKLPSNGP---HQSDSSGNTEPDE ITTIVDMELADTDDEKDMSKPTTDQEAIH--------------------- -------------------------------------------------- -------------------------------------------------- ---------------------WNSNIGEPTMYSNEPIWESDCPRYNAGPP FNNDGMLVPHDYENTFYRTGMRPHEYYQDPGSPHIPAQFYPASSDVYSKC PPIPTGEPGELVALSINEEHLHKMPAIQTATSTAENSAITKKSVVDYVKE CLKDILETTKKHKSNAKKVSTP-SHDGHVLTTNENGASPINAGEFIDPSS PV--------NVGASSQVKKDDDSLSTKMSSYIDRTSLVLSGSPEHVKPI SSKYPLNYLQPSSPKQPNNTPSSILSEIQKQQ-DDDDELLLRERLLMALK CKNPKSLVDPLKAATRVDSMLADTTSIxxDIGSTNTDTAIPCADTKLVST VINLTQAVSIQSAYSPTQTVESLQRNFTYKRRLPPKCQQPPSGVHLARKR VNAARLTTKGGPALSLQVTVPTKEPPEPRKRFVICLGEESDSGTEEDPEM SHEFERSVEVFLRQAREKQEAQTIQGTTPISIRSMPLSQQQEYRRLRDQI AKLEESNHQQRLRLASKNIKAQLPLSPNKKVGSSVPLQNMVIASSHTLKQ INLPNDKTRTKFDKLR---------------------------------- ----------------SCVSATRPSIRTTS-----TTLSKPGRTYTYFNA RGRGTRTISKPYFTNKFAGRRVSASKGLVVTIPGAPPNAGRSKSSLLVQE VSPSLKLSDVSDVAEKNGTCNESWSVTNTNKDEVLKMCHDGHSSSEDCVS SINKNREAAKEETxDEMDVDSILATNVVKSSNLATCKDGLAKSEINERSS VTFNVKSLTNQGTKNDGHSKINTNLIVDSKLISKINFKTSSDKIVAKASL DINLENNIERTSSPNHFEINVDSIHGITDNETTLRMNEVSEITNSLDCSS NMKLNIKGVEIGSENGLKFDTNLSKSTKNHSSFKLESGSKNTCMDSDLGI NDETLSERNNMEFLKEQHLEDLQTQLTDVEQKLLKQRYAVLDDMTVTLDL LNQLEQERSNKDILSEEVKRLRAQLLSAEGRLAQQRKVLQTVRTQTSESY HRVVEGKTACLGLSRQCLMLGISLRGKQYKVPTAAAKIMILKLHQLAKLS QRLKRRSGGEENVITREPPVISPSVCLAQKQV------------------ ------------------------------------------ESETQNLS STIHETRLVSCTRAK---QTDVSISCSEKTQxxLLLDEQGLVGDKVMLNA NSFEYIPFSSKNSANDEELTYEEPATFSLSSNCLALEHPSESSASGTIYR DKVLGLDIDPSRTSETSWTLPADWIHTxxxxxxxxxxxxFEELVExxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxVSISQAMQVRxxxxxxxxxxxxxx xxSRRKxxxxxxxxxxxxxxxEGRNRWRQLRPYFSLK------------- -------------------------------------------------- -------------MLEQxxxxxxxx >Tce x------------------------------------------------- -------------------------------------------------- -----------------------------L-------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------EKIHxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxx---------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------GPALSLQVTVPTKEPPEPRKRFVICLGEESDSGTEEDPEM SHEFERSVEVFLRQAREKQEAQTIQGTTPISIRSMPLSQQQEYRRLRDQI AKLEESNHQQRLRLASKNIKAQLPLSPSKKEGSSVPLHNTVLASSHNLKQ INLPNDRTRTRFDKLRSNVPMLSx-------------------------- ------------------LPATRPNVRTTS-----TTLSKPGRTYTYFNA RGRGTRTISKPYFTNKFTGRRVSASKGLVVTIPGAPPNAGRSTSSLHVQE VSPSLNLSDVSDIAEKNGTCNETWSVTNTNKDEVLK-CHDGHSSSEDCVS SINKNKEAAKEETxDEMDVDSILATNVVKSSKLATCKDGLAK-------- -------------------------------------------------- -------------------------------------------------- -----------------------------------KxGSKNTCMDSDLGI NDETLSERNNMEFLKEEHLEDLQTQLTDVEQKLLKQRYAVLNDMTVTLDL LNQLDQERSNKDILSEEVKQLRAQLLSAEGRLAQQRKVLQTVRTQTSESY NRVVEGKTACLGLSRRCLMLGISLRGKQYKVPTAAAKIMVLKLHQLAKLS QRLKRRSGGEENVITRELPIISPSVSLSQKQV------------------ ------------------------------------------ENETQNLS STIHETPLVSCSRTKQNxQTNVSISCSDKTQxxQLLDEQGLVGDKVVLNA NSFEYIPFSSKNSADDEELTYEEPATLSLSSNRLALEHTSESSASGTIYR DKVLGLDIDPSRTTETSWTLPADWIHT----------------------- -------------------------------------------------- -------------------------------------------------- ---SPDWAVKIDxLHPLCPYDLRGACRDVExxFQHTTWLx---------- -------------------------