>Tge -------------------------------------------------- ME-------xxxxxxxxxxxxxxxxxxxxxxxxxx-------xxx----- -----------------xxxxxxxxxxFGNTDxxxxxxxxxx-------- -----------xxxxxxxLRQDPLFYSxxQxPLF---------------- -----xxxxxx--------Pxxxx---------LRQDPLFY--------- --xxGRxPLxxxxRQDPLFYRLGREP------------------------ -----------xxxxx---------------------------------- -----RRDPLFYSLRQDPL----------------------xxxxxxxxx xxxxxxx--xxxxx-xxxxxxxxxx--xxxxxxxxx--xxxxxxxxx--x xxxxxxxxx--xxxx-----------FYCF--xxxxxxxxxx--xxxxxx xxx-------------xxxxxxxxxxxxxxxxxxx------xxxxxxx-- xxVSNxxxxxxxxxxxxxxx-----------xxxxxxxxx---------- ------xxxxx-------------------xxxQRRLEGCRELSPPGNLL S--DSTCRIKSLGSQ-------------------------------xxxx x------------------------------------------------- -------------- >Tte -------------------------------------------------- M----------------GRPSTKRCNVxxxxxxxxxxxxxxxSRCRHVAR DQVLxxxxxxxxxLLSASENVLLTAxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx---------------- -----xxxxxx--------xxxxxxxxxxxxxxxxxxxxxx--------- --xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxx---------------------------------- ----xxxxxxxxxxxxxxx----------------------xxxxxxxxx xxxxxxx--xxxxx-xxxxxxxxxx--xxxxxxxxx--xxxxxxxxx--x xxxxxxxxx--xxxx-----------xxxx--xxxxxxxxxx--xxxxxx xxx-------------xxxxxxxxxxx---xxxxxxxxxxxxxxxxxxxx xxxx---------------------------------------------- ------------------------------------------xxxxx--- -------------------------------------------------- -------------------------------------------------- -------------- >Tms -----------------------------------------------MYR MQGALHLILPL--------------------VSMV-------SLCKSLIL GSVRPGNFT----LLHEPENPQKVA--FGQPDVNHYLQ------------ -----------RQPGPQQYRNDSLFYA--DGPLFKWLPPGGRGKRYVTAE ETKQSSPDKQETxxxEGLSGLFDN---------QGQNDLVRGKRKSLARR EGYDGVPPITFELIQACRAARLDWPP------------------C----- ----------NLFFSYPWSVYGVDDKDEGNTELEDEDKWLPDPEVDTISL QDNSVSVDTNPRGKRSNPLERKRELNAFREWDDESISKFSNWFRKRGQKF FSWGGKKDPKLFNWGGKRxxxxxSWxxKxxxxxxxxxxxxxxxxxxxxxx xxPKFFSWGxKxDPRxxxxxxxxxxxFFSWGGKRDPKFFSWGGKRDPRFF SWGGKRDPKFFSWGGKxxxxxxxxxxxxx-xxxxxxNE---KTNLDMV-- QPASKNNYINSFPFKKTVSIPEAEGIKQVFSSQRGEIIPLDLAYSEKNDK SDQMLPTDQMSALGETRVMHDHDNNDKHVVTTDQKKSEE-------DNFQ PTFNDVGHIKPLSNREGIKYSLYTEDEDENISFFDSVDSEYKQEFPSISE K------------------------------------------------- -------------- >Tce -------------------------------------------------- MQGALHLILPL--------------------VSMV-------SLCKSLVL GSVRPGNFT----LLHEPENPQKVA--FGQPDVNHYLQ------------ -----------RQPGPQQYRNDSLFYA--DGPLFKWLPPGGRGKRYVTAE ETKQSSSEKQETxxxEGLSSLFDN---------QGQDDLVRGKRKSLARR EGYDGVPPITFELIQACRAARLDWPP------------------C----- ----------NLFFSYPWSVYGVDDKDEGNTELEDEDKWLPDPEVDTISL QDNSVSVDPNPRGKRSNPLERKRELNAFREWDDESISKFSNWFRKRGQKF FSWGGKKDPKLFNWGGKRDPRFFSWGGKxxxxxxxxxxxxxxxxxxxxx- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- x------------------------------------------------- -------------- >Tsi -----------------------------------------------MYR MQGAMHLIIPL--------------------VSMV-------SLCKSLIL GSVRPGNFT----LLHEPENTQNVA--FSQPDVNHYLQ------------ -----------RQPGPQQYRNDSLFYA--DGPLFKWLPPGGRGKRYVTAE ETKQSSSETQETxxxEGLSGLFDN---------QGQEDLVRGKRKGLARG EGYDGVPPSTFELIQACRGARLDWPP------------------C----- ----------NLFFSYPWSVYGVDDKDEGNTELKDEEKWLPDSEVDTISL QGNSVSVDPNPRSKRSSPLERKRELNAFREWDDESISKFSNWFRKRGQKF FSWGGKKDPKLFDSGRKRxxxxxSWxxKxxxxxxxxxxxxxxxxxxxxxx xxPRFFSWG--xDPKxxxxxxxxxxxFFSWGGKRDPKFFSWGGKRDPRFF SWGGKRDPRFFSWGGKxxxxxxxxxxxxx-xxxxxxNE---KTNLDMV-- QPASKNNYSNILFFKKTVSIPDAKGIKHVFSSQRGEIIPLDLTYSEKNDK SDQMLPTDEMKTLGETRVMHDHDNNDKHVVTPDQKKSEED---AFPDNFQ PTFNDVGHIKPLSNREGIKYSLYSEDEDENISFFDSVDSEYKQEFPSISE K------------------------------------------------- -------------- >Tcm -------------------------------------------------- MQGAMHLIIPL--------------------VSMV-------SLCKSLIL GSVRPGNFT----LLHEPENTQNVA--FSQPDVNHYLQ------------ -----------RQPGPQQYRNDSLFYA--DGPLFKWLPPGGRGKRYVTAE ETKQSSSETQETxxxEGLSGLFDN---------QGQEDLVRGKRKGLARG EGYDGVPPSTFELIQACRGARLDWPP------------------C----- ----------NLFFSYPWSVYGVDDKDEGNTELKDEEKWLPDSEVDTISL QGNSVSVDPNPRSKRSSPLERKRELNAFREWDDESISKFSNWFRKRGQKF FSWGGKKDPKLFDS------------------------------------ ------------------------------xxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxx------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------- >Tps MxGRVSRGVIRTRREARSEQCSPxxxxxHRTKDSSEQATVSIEKLFLMYR MQGALHLIIPL--------------------VLMV-------SLCKSLIL GSVRPANFT----LLHEPENTQKVA--FGQLEVNHYLQ------------ -----------RQPGPQQYRNDSLFYA--DGPLFKWLPPGGRGKRYVTAE ETKQSSSKKQE----EGLSGLFDN---------QGQEDLVRGKRKGLARG EGYDGVPPITFELIQACRGARLDWPP------------------C----- ----------NLFFSYPWSVYEVDDKDEGNTELKDEDKWLPDSEEDTISL QGNSVSVDLNPRSKRSSPLERERELNAFREWDDESISKFSNWFRKRGQKF FSWGGKKSPKLFDSGGKRxxxxxSWxxKxxxxxxxxxxxxxxxxxxxxxx xxPKFFSWGxxRDPR-----------FFSWGGKRDPRFFSWGGKRDPRFF SWGGKRDQKFFSWGGKxxxxxxxxxxxxx-xxxxxxNE---KTNLDMV-- QPASKNNYNHILYFKKTVSIPDAKGIKQVFPNQRGEIIPLDLTYSEKNDK SDQMLPTDEMKALGETRVMHDHDNNDKHVVTPDQKKSEED---AFPDNFQ PTFNDVRHINPLSNREGIKYSLYSEDEDENISFFDSVDSEYKREFPSISE KAxxxxxx---------------------------------EFIKSLVTI PLWLFKVAQLDVHG >Tdi -------------------------------------------------- MQGALHLIIPL--------------------VLTV-------SLCKSLIL GSVRPANFT----LLHEPENTQ-VS--FGQLEVNHYLQ------------ -----------RQPGPQQYRNDSLFYA--DGPLFKWLPPGGRGKRYVTAE ETKQSSSEKQE----EGLSGLFDS---------QGQEDLVRGKRKGLARG EGYDGVPPITFELIQACRGARLDWPP------------------C----- ----------NLFFSYPWSVYEVDDKDEGNTELKDEDKWLPDSEEDTISL QGNSVSVDPNPRSKRSSPLERKRELNAFREWDDESISKFSNWFRKRGQKF FSWGGKKSPKLFDSGGKRxxxxxSWxxKxxxxxxxxxxxxxxxxxxxxxx xxxxxFxxGxxxDPR-----------FFSWGGKRDPRFFSWGGKRDPRFF S------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-------- -------------- >Tbi -------------------------------------------------- MQGALHLILPL--------------------VSMV-------SLCESLIL GNVRPGNFT----LLHQPENTRKVA--FGQPDVNHYLQ------------ -----------RQPGPQQYRNDSLFYA--DGPLFKWLPPGGRGKRYVTAE ETKQSSSEKQE----EGFTGLFDN---------QGQEDLVRGKRKSLARG EGYDGVPPITFELIQACRAARLDWPP------------------C----- ----------NLFFSYPWSVYGVNDKEEGSPELKDEEKWLPDPEVDTISL QDNSVSVDPNPRGKRSSPLERKRELNAFRAWGDESTSKFSNWFRKRGQKF FSWGGKx-----------xxxxxSWxxxxxxxxxxxxxxxxxxxxxx--- -------------------------------------------------- ------------------------------------NE---KTNLDMV-- QPASKNNYSNSLPFKDTVSILDAEGIKQVLSSRRGEIIPLNLPYSGKNDK SDQMLPTDEMNALGETGVMHDHDNNDKHVVTIDQKKSEEDVDVAFPDNFQ PTFNDVGHIKPLSNREGIKYSLYSEDEDDNISFFDSVDSDYKKDFPSVSE K------------------------------------------------- -------------- >Tpa -------------------------------------------------- MQGALHLILPL--------------------VSMV-------SLCESLIL GNVRPRNFT----LIHQPENTRKVA--FGQPDVNHYLQ------------ -----------RQPGPQQYRDDSLFYA--DGPLFKWLPPGGRGKRYVTAE ESK---PEKQE----EGITGLFDN---------QGQEDLVRGKRKSLSRG VGYDGVPPITFELIQACRAARLDWPP------------------C----- ----------NLFFSYPWSVHGVNDREEGSPELQDEEKWLPDPEVDTVSL QDNSVSVDPNPRGKRSSPLERKRELNAFRLWGDESISKFSNWFRKRGQKF FSWGGKx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------