>Tge -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------LVESLKSKLGKVSEEVENL EAAEVDIEQAHRKLQELQKEVRGLYVFKEDVDAAESDLQSLKGRVDGCIS QAKTLVSETKDRYIGLQQLVPTDIAQ------------------------ -------------------------------------------------Q LSSLELLWETVSGAMEEKSRDLKRARTVRSEYTADVDEVQDWLQRAEAQV QDRSLDPHKQKEYLM--------------------------------QFQ GELGSVDDRMERLTKNGGVLIGNSRDDAEKALVQSTINTLTERLQQFRSC LEQKKHQVGDTLDSWQRFMTMYQAVKSWVDEKQTFLVEPLQLSSLTQARQ KVHDYS---------------------------TAVKTCKQMTKNLSDMS KELENIGQVNSVGDLPEKLEEVEETKGEVEAQLLER-------------- -------------------------------------------------- --------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxTxxxxTYLRFTNCLGAxxNALLLETSEEWEQC --------------------EKKMKDVRAWMDKSRQSLESPQNKKKPLRD QLAMRDKMVGDIAIQKTKISISAEKLQVHFRSGVGGDSKVTEAAQEILKE LDQFHEVVKEQSNTLDTCLLQLDQYQQEIQQLRQQIVQVETQLRIVLSPT YLPHERDRAAEEQNVCRERVVALQTKIAARNERMKLLAQRGTPDTEPLDS >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------QSLKGRVDGCIS QAKTLVSETKDRYIGLQQLVPTDIAQ------------------------ -------------------------------------------------Q LSSLELLWETVSGAMEEKSRDLKRARTVRSEYTADVDEVQDWLQRAEAQV QDRSLDPHKQKEYLM--------------------------------QFQ GELGSVDDRMERLTKNGGVLIGNSRDDAEKALVQSTINTLTERLQQFRSC LEQKKHQ------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- >Tbi x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------xxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxLVESLKSKLGKASEEVENL EAVEVDIEQAHRKLQELQKEVRGLYVFGEDVDAAESDLQSLKGRVDGCIS QAKTLVSETKDRYIGLQQLVPTDIAQ------------------------ -------------------------------------------------Q LSSLELLWETVSGAMEEKSRDLKRARTVRSEYTVDVDEVQDWLQRAEAQV QDRSLDPHKQKEYLM--------------------------------QFQ GELGSVDDRMERLTKNGGVLIGNSRDDAEKALVQSTINTLTERLQQFRSC LEQKKHQVGDTLDSWQRFMTMYQAVKSWVDEKQTFLVEPLQLSSLTQARQ RVHDYS---------------------------TAVKTCKQMTKNLSDMS KELENIGQVNSVGDLPEKLEEVEETKGEVEAQLLER-------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------NALLLETSEEWEQC --------------------EKKMKDVRAWMDKSRQSLESPQNKKKPLRD QLAMRDKMVGDIAIQKTKISISAEKLQVHFRSGVGGDSKVTEAAQEILKE LDQFHEVVKEQSNTLDTCLMQLEQYQQEIQQLRQQIVQVETQLRIVLSPT YLPHERDRAAEEQNVCRERVVALQTKIAARNERMKLLAQRGTPDTEPLDS >Tte x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------------xxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxLVESLKSKLGKASEEVENL EAVEVDIEQAHRKLQELQKEVRGLYVFGEDVDAAESDLQSLKGRVDGCIS QAKTLVSETKDRYIGLQQLVPTDIAQ------------------------ -------------------------------------------------Q LSSLELLWETVSGAMEEKSRDLKRARTVRSEYTVDVDEVQDWLQRAEAQV QDRSLDPHKQKEYLM--------------------------------QFQ GELGSVDDRMERLTKNGGVLIGNSRDDAEKALVQSTINTLTERLQQFRSC LEQKKHQVGDTLDSWQRFMTMYQAVKSWVDEKQTFLVEPLQLSSLTQARQ RVHDYS---------------------------TAVKTCKQMTKNLSDMS KELENIGQVNSVGDLPGKLEEVEETKGEVEAQLLER-------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------NALLLETSEEWEQC --------------------EKKMKDVRAWMDKSRQSLESPQNKKKPLRD QLAMRDKMVGDIAIQKTKISISAEKLQVHFRSGVGGDSKVTEAAQEILKE LDQFHEVVKEQSNTLDTCLMQLEQYQQEIQQLRQQIVQVETQLRIVLSPT YLPHERDRAAEEQNVCRERVVALQTKIAARNERMKLLAQRGTPDTEPLDS >Tsi x------------------------------------------------- ------xxxxxCQIGPQNCVDVGNTGVGGGGTIYIRQQTNKQTTRPTPSR GPGLLPPVAPLQRLKGPHxxxLALTNGLYLRxxxxxxxxxxxxGSLxxxG GMPGLIQIVSNTRARLDGRGSNFENGIRKWKYQVAGR------------- -------------------------------------------------- ------------------------ALEGTFTLEGLSE-----------AL EGTFTLEGLSEALE---------ETFxLEGLSEAIEGTFTxxGLSEALEG TLTLEGQSEALEGTLTLEGQS----------------------------- -------------------------------------------------- -------------------------------------------------- ---------LLRPxxxxx---------VQRICxxxISxxxxxxxxxxxxx xx--------------------------AASNPxxxxPRTLKSKAKLGLT SDKCxxxxxxxxxxxPHLSHAPLREMSGFNTDLARGSRCPSAPPVESLxL xxxFSGYTxxxxxxxxxxxxxxx--------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxxxxxERARER-----CSERAxxxxxx--xxxxxxx xxxxxLLxxxxxTRxxxxxxxxxxxx------------------------ ---------------------------------------------xxxx- --------------xxxxxxxxxPGxx--------------------x-- ------------------------------RLVESLKSKLGKVNEEVEHI EAVEVDIEQAHRKLQELQKEVRGLYVFGEDVDAAESDLQSLKGRVDSSIS QAKTLVSETKDHYIGLQQLVPTDIAQxF---------------------- ----------------------------------RATIRVIYWSVVVV-Q LSSLELLWETVSGAMEEKSRDLKRARTVRSEYNADVDEVQSWLQRAEAQV QDRSVDPHQQKEYLM--------------------------------KFQ GELGSVDDRLERLTKNGGVLIGNSRDDGEKALVQSTINTLTERLQQFRSC LEQKKHQVGDTLDSWQRFMTMYQAVKSWVDEKQTFLVEPLHLSSLTQARQ KVHDYS---------------------------TAVKTCKQMTKNLSDMS KELESIGQVNSVGDLPEKLEEAEEAKGEVEAQLLERIFDKLDKRGSTLYS SPRASLVLTDSVEKLPDQVTYHYAKSNDLQKH------------------ -------------------------------------------------- ------------------------------------NGLLLETSEEWEQC --------------------EKKMKDVRAWMDKSRQSLESPQNKKKPLRD QLTMRDKMVMDVATQKTKISISAEKLQVHFRSGVGGDSKVTEAAQEILKE LDQFHEVVKEQSNTLDTCLLQLDQYQQEIQQLRQQIVQVESQLRIVLSPT YLPHERDRAAEEQNVCRERVVALQTKIAARNERMKLLAQRGTPDTEPLDS >Tps -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------LVESLKNKLGKVSEEVEHI EAVEVDIEQAHRKLQELQKEVRGLYVFGEDVDAAESDLQSLKGRVDSSIS QAKTLVSETKDHYIGLQQLVPTDIAQxF---------------------- ----------------------------------LATIRVIYWSVVVV-Q LSSLELLWETVSGAMEEKSRDLKRARTVRSEYNADVDEVQSWLQRAEAQV QDRSVDPHQQKEYLM--------------------------------KFQ GELGSVDDRLERLTKNGGVLIGNSRDDGEKALVQSTINTLTERLQQFRSC LEQKKHQVGDTLDSWQRFMTMYQAVKSWVDEKQTFLVEPLQLSSLTQARQ KVHDYS---------------------------TAVKTCKQMTKNLSDMS KELESIGQVNSVGDLPEKLEEAEEAKGEVEAQLLER-------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------NGLLLETSEEWEQC --------------------EKKMKDVRAWMDKSRQSLESPQNKKKPLRD QLTMRDKMVMDVATQKTKISISAEKLQVHFRSGVGGDTKVTEAAQEILKE LDQFHEVVKEQSNTLDTCLLQLDQYQQEIQQLRQQIVQVESQLRVVLSPT YLPHERDRAAEEQNVCRERVVALQTKIAARNERMKLLAQRGTPDTEPLDS >Tdi xx------------------------------------------------ ---xxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------ERERER-----CSERAxxxxxxxTxxxxxxx xxxxxLLxxxxxTKxxxxxxxxxxxx------------------------ ---------------------------------------------x---- -------------------------xxxxxxxxxxxxxxxxVWARxxx-- ------------------------------xLVESLKNKLGKVSEEVEHI EAVEVDIEQAHRKLQELQKEVRGLYVFGEDVDAAESDLQSLKGRVDSSIS QAKTLVSETKDHYIGLQQLVPTDIAQxF---------------------- ----------------------------------WATIRVIYWSVVVV-Q LSSLELLWETVSGAMEEKSRDLKRARTVRSEYNADVDEVQSWLQRAEAQV QDRSVDPHQQKEYLMLDEPPSSPLRAGIETWPLRLNYGAVTCVAVLQKFQ GELGSVDDRLERLTKNGGVLIGNSRDDGEKALVQSTINTLTERLQQFRSC LEQKKHQVGDTLDSWQRFMTMYQAVKSWVDEKQTFLVEPLQLSSLIQARQ KVHDYS---------------------------TAVKTCKQMTKNLSDMS KELENIGQVNSVGDLPEKLEEAEEAKGEVEAQLLERIFARLDKRGSTLYS SPRASLVLTDSVKKLPDQITYHYAKSNDLQKHAFFLPPLCANVLILCSLV MYVSKLVVx----------------------------------------- -----------------------------------xNGLLLETSEEWEQC --------------------EKKMKDVRAWMDKSRQSLESPQNKKKPLRD QLTMRDKMVMDVATQKTKISISAEKLQVHFRSGVGGDTKVTEAAQEILKE LDQFHEVVKEQSNTLDTCLLQLDQYQQEIQQLRQQIVQVESQLRVVLSPT YLPHERDRAAEEQNVCRERVVALQTKIAARNERMKLLAQRGTPDTEPLDS >Tce x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- --------------------------------------xxxxxx--xxxx xxxxxxxxxxxxTRxxx--------------------------------- ------------------------------------------------xx xxxxxxxxxxxxxxxx---------------------------------- -------------------------------LVESLKSKLGKVSEEVEHL EAVEVDIEQAHRKLQELQKEVRGLYVFGEDVDAAQSDLQSLKGRVDSSIS QAKTLVSETKDHYIGLQQLVPTDIAQxVxLEEVNPHLRGGRVENNLEKTT PVHPTEIRTSISPSSAVGLNTTSALANYDTEAVxWATFRVIYWSVVVIxQ LSSLELLWETVSGAMEEKSRDLKRARTVRSEYNVDVDEVQDWLQRAEAQV QDRSVDPHQQKEHLT--------------------------------KFQ GELSSVDDRMERLTKNGGVLIGNSRDDGEKALVQSTINTLTERLQQFRSC LEQKKHQVGDTLDSWQRFMTMYQAVKSWVDEKQTFLVEPLQLSSLTQARQ KVHDYSVSRTLNTSGGALVSTRCYMGESSSVYTTAVKTCKQMTKNLSDMS KELENIGKVNSVGDLPEKLEEAEEAKGEVEAQLLER-------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------NGLLLETSEEWEQC --------------------EKKMKDVRAWMDKSRQSLDSPQNKKKPLRD QLNIRDKIVMDIATQKTKISISAEKLQVHFRSGVGGDSKVTEAAQEILKE LDQFHEVMKEQSNTLDTCLLQLDQYQQEIQQLRQQIVQVESQLRIVLSPT YLPHERDRAAEEQNVCRERVVALQTKIAARNERMKLLAQRGTPDTEPLDS >Tcm xx--xxxxxxxLxxxxxxxxxxxxxDASAGRxxxxxxxxxxxxxxxxxxx xxxVLER------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------ERERER-----CSERAxxxxxxxx--xxxxx xxxxxLLxxxxxTRxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxx-----------xxxxxxx-------------xxxxxx-x- -------------------------------------------------- -------------------------------------------------- ---------------------------------------SLKGRVDSSIS QAKTLVSETKDHYIGLQQLVPTDIAQxF---------------------- ----------------------------------RATIRVIYWSVVVV-Q LSSLELLWETVSGAMEEKSRDLKRARTVRSEYNADVDEVQSWLQRAEAQV QDRSVDPHQQKEYLM--------------------------------KFQ GELGSVDDRLERLTKNGGVLIGNSRDDGEKALVQSTINTLTERLQQFRSC LEQKKHQVGDTLDSWQRFMTMYQAVKSWVDEKQTFLVEPLQLSSLTQARQ KVHDYS---------------------------TAVKTCKQMTKNLSDMS KELESIGQVNSVGDLPEKLEEAEEAKGEVEAQLLERIFDRLDKRGSTLYS SPRAxLVLTDSVEKLPDQITYHYAKSNDLQKH------------------ -------------------------------------------------- ------------------------------------NGLLLETSEEWEQC --------------------EKKMKDVRAWMDKSRQSLESPQNKKKPLRD QLTMRDKMVMDVATQKTKISISAEKLQVHFRSGVGGDSKVTEAAQEILKE LDQFHKVVKEQSNTLDTCLLQLDQYQQEIQQLRQQIVQVESQLRVVLSPT YLPHERDRAAEEQNVCRERVVALQTKIAARNERMKLLAQRGTPDTEPLDS >Tms xxxxx--------------------DxxxxR------------------- -------------------------------------------------- ------------------------------------------xGCPxxxG GMPGLIQIxxxxRAxxxxxxSxxxxxxxxWKYQVAGTxxxKIVLYNNPRP SSYVSLLTHVSGPLCPPGTRAGNIVTWPRKGRKIDYILILAIKILLQCVN WFTLRVLSLTRHLGPGLVHSLLAGALEGTFTLEGLSEALDLVHSLLAGxL EGTFTLEVLSETLERTFxLEGLKRTFTLEGLSEALEGTFTxxxLSEALEG TFTLEVLSEALEGTFTLEGLSEPHHNWVGVTTLALGTACLYRGVTTQALG TACLYRGVxxxxxxTACLYRGVxTLALGTACxxxxxxTLPLGTACLYRGV TTLALGTACLYRGQPLxxxNPFSSxxQxxxRALCVxxxxxxxDIEWGEKA AAAIAVICLLSxxxxxxxxxxxxxxxxxxxxxxxxIIxxxxxxxxxxxxx xxCDExxVCGxxxxxxPSTNATNAxExEALTN------------------ -------------------------------------------------- --------------------QHRxxxxxxHFGGYAGTSVPLEPRVPGVIY RVGSPRGQRxxxxxxxxxxxxxxxxxxxxxxxxxxxxxVVTQPDLSGTCG AGSDKPTAATxxxxxPCxGGTRLTPxxxxxxxxxxVxxxCSGKLxxxxxx xxxxxxxxxxxxxxxxx--ERERERAAPxxCSE----------------- ----------------xxx------------------------------- --------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx------- -------------------------------------------------- -------------------------------LVESLKSKLGKVSEEVEHL EAVEVDIEQAHRKLQELQKEVRGLYVFGEDVDAAQSDLQSLKGRVDSSIS QAKTLVSETKDHYIGLQQLVPTDIAQ------------------------ -------------------------------------------------Q LSSLELLWETVSGAMEEKSRDLKRARTVRSEYNVDVDEVQDWLQRAEAQV QDRSVDPHQQKEHLT--------------------------------KFQ GELSSVDDRMERLTKNGGVLIGNSHDDGEKALVQSTINTLTERLQQFRSC LEQKKHQVGDTLDSWQRFMTMYQAVKSWVDEKQTFLVEPLQLSSLTQARQ KVHDYS---------------------------TAVKTCKQMTKNLSDMS KELENIGKVNSVGDLPEKLEEAEEAKGEVEAQLLER-------------- ----------------------xxxxx----------------------- -------------------------------------------------- -----------------------------------------------xxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxx--------------------- -------------------------------------------------- -------------------------------------------------- --------------ACKHR------------------------------x