>Tge ------------------------------------------------------------ -----------------------------------------------MDN---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --NAPATNTTHEPDIESL-------TPGLWLNAPLLYHQLVRVRETER-------RGHIA QCN---NRQQGNDLETYL------------------------------------------ --------------FPNLSI---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------VRQGVGNKW-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------VKEKLKTEEEI---FNMKEHIHTL TKVKEDQRTKIDSLEKCIEELKHTSEEAAETLNTYLEQTRNENSHLTKQNKDLIIDSKKK AEAEEILKKKISSLQDDLDEVTDAIIAAIVSRYIVTSVLQKQQLLKVTENLSEYVIHALM NSPAILFRYHCWVNEDHPLGYVLQPQH--------------------------------- ----------------------------------------------------------HK NKVQPS------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------KVGASLVRVTVL------------------- ------------------------------------------------------------ --------------------------------------------------PLF----KLF L--------------------------------------------------IPQ------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------QKAAFTMLAV------------ --------------------------------KVFLITKSG------I >Tsi ------------------------------------------------------------ -------------MYMKDNIESLSLLLTTTKDELLKLQKEHT---DLLDNIQANEGSSTA LQQLNQMN---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ELSIQ IKNLHLQHTEKDLEINSLKKILQEKTEKLAETANTIHGLEKNISELDKLLSHWKEKAYVA QNSLLSN----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------SDTLALSVACLSTELKVLGLIPVIAEQSLIGEILTSP----- -PPSTLTMIKGLRANDSTPRALLHIFYITPHPWRHNCWWSTDEIFIDYDSLIEYFIKSLD DLVSRSLVHYAKVLKENEKNIIPELQESGILQKLKSIAQTLTIHCRSLLYNVDNNCVEHY NTAIVKKKTGGKRIYFTQRGSYQARCAAAVVSYNSGALHYKLHKKLYGPSPGKFTKFEEA RKRRKMSRPKKKREDSHHSKPIRSSKPFFPIPPKENELQNSLQHSEEELRNLEHQTINQI CRKLPSTGCENLVKQILNSELQHLSSLSYGKANEERAIAKLEETLKIRVECCGFFVDRDL TFLGATPDGLIDNVGIVEVKCPSSAEQMSPESAILQRKEKLKLQEDI---FNTQEYISSL TMDNQGYKTKIDSLEKCIEELKNTSEEAAEVLNMSLEQTRNENSLLTNQNKDLIIDFKKT AEAEEILKKKISSMQDDLDEVT------ALEAKIEASQLEQKTLLERCFSSSSTCDSLQR TVNEIRRRLEESQAALHEMGRENQNLQLKLEKL-VGRKWTEDS---DAASIAKDNYLATW -STSTFPHLETVSTHYDKLTVSTGLYSLRANRPVPRLMLSFHIMSKTDGKLEALIGQ--- -ESAPNP-PPPLKDHTCKQQVRLTASGANPPVPASDAFLSDKVKNRRYTRGTDWPGVRAK TSPFPERPHVQEQETTNYKAFTPIYLSVNKVGMGPLAPYTLNSLSCGPHFKFHIDTKVTT QGYIFFDANAAALVPIFGGGSTGVTSPARHSAAPAKSPRGCTPGPEQFGGGWVEPQRKPG QVQTSDKRLVRAKTTILKQGLASWLPAWWAESVRVGDEELTGDEGQLNPQPSPTPSGWLW TLVNGVLTKSTCSTQSPTKLQQERLDTLQ----------------------GIGKVEIEE VNP--------------HLR---GGRVENHLGKTTPSSPDRDSNLDLPVLSSRAQHDKR- ----------------VSQLRHRGGYTGRRVTAQTVRRGKLAIWLPNNLCVSQIECGDQL RERSMIMAPEVFIFNYTNFSLLDIAPSYPNAHGIQFLDSRSAVTVISFTYNFCLDSDTAA RIQAKPTKSLPNCLADRWCHVVSTTITPDINLGFLYRSHYYFIRYFSIHPPVYEKDTKIF VWNCALESASEVVFDYCVHAHIGGGVEEGGTASWGIHPVGCLCPSGTARGRIPSAFLASR VCDHRRGVVSRRCGIQLWRLLQSGPYQAMRGRSGWGAGRRMKRQGCSEKGGGAAGAATAG AIKIGKTTKSLESANVDCPRGQANNDSETTMVRFLNSKANRFSEPAIVESYRVQAASGLE LTVAGVPEIRLAFLRGDCDWRPECASSITTLRL-----RPRCFESNVGVDAPPIQKEVGK TNTHHPNRSVEAMALPDGAQPSPPLRAGEWLTRVIHIPAEDLAAAGPS >Tcm ------------------------------------------------------------ -------------MYMKDNIESLSLLLTTTKDELLKLQKEHT---DLLDNIQANEGSSTA LQQLNQMN---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ELSIQ IKNLHLQHTEKDLEINSLKKILQEKTEKLAETANTIHGLEKNISELDKLLSHWKEKAYVA QNSLLSN----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------SDTLALSVACLSTELKVLGLIPVIAEQSLIGEILTSP----- -PPSTLTMIKGLRANDSTPRALLHIESLAPGLW--------------------------- ------------------------------------------------------------ --------------------------------LNAPLLYY-------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------QEKLKLQEDI---FNTQEYISSL TMDNQGYKTKIDSLEKCIEELKNTSEEAAEVLNTSLEQTRNENSLLTNQNKDLIIDFKKT AEAEEILKKKISSMQDDLDEVT------ALEAKIEASQLEQKTLLERCFSSSSTCDSLQR TVNEIRRRLEESQAALHEMGRENQNLQLKLEKL-VGRKWTEDS---DAARCIK------- ------------------------------------------------------------ ----------------CEK----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------VF TLL--------------------------------------------------------- ------------------------------------------------------------ -----------------------------------IRR---------------------- -------------------------------HHCR------------------------- -----------NCF-------------------------------------------KIY CNECSAKTAA---------------VES---------------------DRKPV-----R VCDS-------------------------------------------------------- ------------------------------------------------------------ -----------------------------------------CFNELSS------------ -----------------------------------------------K >Tps ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------MQPDGTGRTG SSNPPNQPSKSPGIHHALSYGGAADLGRLQAESDMGPTVIPRSFHRAVRLDYIHPSPTSF HPLASELPITHLQCGPSLIGSFGRLIYGVGMRQLPEPSFLKAGLLILEGNFGHSLELSIQ IKNLHLQHTEKDLEINSLKKILQEKTEKLAETANTIHGLEKNISELEKLLSHWKEKAYVA QNSLLSNEKEMIEFKTNLETEMVELSIESNTKVSKFSEIILNLKLELESACTDAKNYKLQ LSENAELHEELSKVFPRALIGKVGDKTTCKVWCVQCGYMNQIF-ALQQVIEKCVAVRKKV YCS-------------------VVDLEKAYNQVNRSMVWMHDYAVLMAEDERDLQNALNC LNGATDRMDLCIDVSKAKSDTLALSVACLSTELKVLGLIPVIAEQSLIGEILTSP----- -PPSTLTMIKGLRANDSTPRALLH------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------EKLKLQEDI---FNTQEYISSL TMDNQGYKTKIDSLEKCIEELKNTSEEASQVLNTSLEQTRNENSHLTQQNKDLIIDLKKT AEAEEILKKKISSMQDDLDEVTGEKL--ALEAKIEASQLEQKTLLERCFSSSSTCDSLQR TVNEIRRRLEESQAALHEMGRENQNLQ--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------ >Tdi MNLCCGKVVAKCWDRRGLQYVLISPVVRSCGRVSEPTADGDGKIECGCIVLACGKPCDGR ----LMLKQPHTELFRKDNIESLSLLLTTTKDELLKLQKEHT---DLLDNIQANEGSSTA LQQLNQMNGSAHQTWGAAQQVVMKGLYEEGTQDVVTQVFIQDFNSTPWLVRLHNCILKET PSPFPQVTTSQSLQTALNGPRKEEPTAREQTALMGWVVSRQATHQPRFRHMQPDGTGRTG SSNPPNQPSKSPGIHHALSYGGAADLGRLQAESDMGPTVIPRLFHRAVRLDYIHPSPTSF HPLASELPITHLQCGPS---------YFCGL-NIPVTSL-----------FLSHIELSIQ IKNLHLQHTEKDLEINSLKKILQEKTEKLAETANTIHGLEKNISELEKLLSHWKEKAYVA QNSLLSNEKEMIEFKTNLETEMVELSIESNTKVSKFSEIILNLKLELESACTDAKNYKLQ LSENAELHEELSKFFPRALIGKVGDKTTCKVWCVQCGYMNQIF-ALQQVIEKCVAVRKKV YCSVVDLEKAYNQVNRSMVWMHVVDLEKAYNQVNRSMVWMHDYAVLMAEDERDLQNALNC LNGATDRMDLCIDVSKAKSDTLALSVACLSTELKVLGLIPVIAEQSLIGEILTSP----- -PPSTLTMIKGLRANDSTPRALLH------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------EKLKLQEDI---FNTQEYISSL TMDNQGYKTKIDSLEKCIEELKNTSEEASQVLNTSLEQTRNENSHLTKQNKDLIIDLKKT AEAEEILKKKISSMQDDLDEVT------ALEAKIEASQLEQKTLLERCFSSSSTCDSLQR TVNEIRRRLEESQAALHEMGRENQNLQITPFER-VQSEAKENL---DPIR---------- -------------SDFIAQSVVCLLAELRV------L---AKARSGADERQEAGQGQNHK LETGPGQLAPSLVGWECEGWGQRAESLSAPLASVSEAYYHNKVYLVTYRWQLRYPG---- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------VGCDRPTGDEGRLNPQPSPTPSGWLW TLVNGVLTKSTRSTQSPTKLQQERLDTLQVHPTKIRNSISPSSAVELNTTNALANYATEA VNNMKAITQKKKAPPTIHLNVAPTGRCGAVLPPGSPCVDCTEVHSGLGLLRSTAAVETQS VIEKEKGKGEQVSANHVLQLQHSPEWSSRRVSA--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---CALRAKRE------------KQYEA------------------TRKQAIP------- ----------------------------------------IKR----------------- PLYVGKDSANIFRLRVSC--GQLNEPSSLLL---------QFSRPKLL------------ --------------------LPYSSSSFVLKRLSLVLFQSHCFTEKIG------------ -------------------------------------SAED------- >Tpa ---------------------MLQLASWSSGW-SAPLATNDLKI----------RGLDSR HTIALKLCEITFVLRMKDNIESLSLLLTSTKDELLKLQKEHT---ELLDNIQANEGSSTA LQQLNQMN---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------ELSFQ IENLHLQHTEKDLEIDSLKKILQEKTEKLAETANTIHGLEKNTSELEKLVSHWKEKAYLA QNSLLSNEKNMMEFKTNLEVEMSDLSIDCNTKVSELSEMIFNMKIDLESACTDAKNYKLQ LSENAKLHEELKQNYESLLM-------LCSVEVKEENVRVEIWNEINEVLNAC------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------ETG------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------ERIILLGDMNGWVGTQRESSAI VLGRFG------------------------------------------------------ --------------DDRVDE---------------------------------NCNEL-- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------ >Tbi ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------LEAKIEASQLEQKTLLERCFSSTSTCDNLQR TVNEIRRRLEESQAALHEMGRENQNLQALTDEMRTLSKRNEHKHLGDAAHGDAENLMANI RDTAKTPAIHQLVS-WLQSRVELVKVSLQNYP---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------VCRIAIEADK II--------------YIQRGHSA-----RFGAAWVRK---S------------------ ------------------------------GH---------------------------- ---------------------------------------------------------RVF V------------------------LEG-------------------------------K RCD--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------ >Tte MS---------------------------------------------------------- ----------------------------------LKLRGGNAFTHSVSDSVWSRDVSVT- -------N---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------PYR LKNLTLFSSPLLLP----------------------HGTAAR---------HYFAGGGIS CCSALPT------------VEYTRIPLDT------------------------------- LSSQA---------FPSFVF---------------------------------------- ------L----------------------------------------------------- ----------------------------------------LLASVSYLDRHFSAPYFLNH LLERVRCRLAKVILGMETLHAYIHNLTLS------------------------------- -----------------------ECEKQRGEGTL-------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------RSEKLKTEEEI---FNMKEHIHTL TKVKEDQRTKIDSLEKCIEELKHTSEEAAETLNMYLEQTRNENSHLTKQNKDLIIDSQKK AEAEEILKKKISSLQDDLDEVT------ALEAKIEASQLEQKTLLERCFSSTSTCDNLQR TVNEIRRRLEESQAALHEMGRENQNLQALTDEMRTLSKRNEHKHLGDAAHGDAENLMANI RDTAKTPAIHQLVS-WLQSRVELVKVSLQNYPGLPK------TNNNIEGWHRGL--QQHI SASHPN------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------IW KFVSAI------------KMEQ-----------------------------SLNEVRIEQ YTS--------------------------------------------GQKPSRRPIEADK II--------------YIQRGHSA-----RFGAAWVRK---S------------------ ------------------------------GH---------------------------- ---------------------------------------------------------RVF V------------------------LEG-------------------------------K RCDQ----------------------------------SRSSRQ---------------- ------------------------------------------------------------ ------------------------------------IFATSAMTALLAA----------- -NNHHSSANKHS------------------ISRVFTVLIVSR-----S