>Tge -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------x------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------xxxxxxxxGVTYPCIHAVWARWAPPLERSRMASLAFAGS YVGTVVSLPICGILANELGWPSIFYVFG---------------------- ------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-- -------------------------------------------------- ----------------------NLVHPWRKFFTSMPVWAVIVAHFCENWG FYTLLTQLPTFMK--------DALEFNLKKAGFMSALPYLVMAIVLSFSG QLADYLITNKYLNTSQ---------------------------------- -------------------------------------------------- -----------------------------------------xRKLFTCSA FMGQ--------AVFMLMTCFLLTPTGAVSCLTAAVGLGAFAWSGFSVNH LDIAPQHASVLMGLSNTMATLPGIISPSITGILVQNK------------- ----TVDEWRVVFYMASSIYLFGALFYGAFSSGQIQPWAEHK-NNQDRTK IDEK >Tms x------------------------------------------------- ---------------------------------xxxxDDYIISLGSFEAS NExxxxxxxxVxxxxIPxKNFxDIVIRxxxASQxxxxxxxxxxKxxxxxx xxxxxxxxxxxxxxSHxxxxxxxxxHxxxHWxTDKEILCALGLWxxxxx- -------xxxxxxGDGLGPMYFFWRRRRYMVAMLAFFGFFNVYALRVNFS VAIVAMTSNRTVEENGTIVEY----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------GPEFDWDSKTQGLLLS SFFFGYICTQILGGWLASRIGGNKVYGIGIAATSILTIVMPAVTYFPDHA VIPMIILVRVVEGLFEH-----------------------KGTRLSRTCY SAVCDIDE----------------EQGYFGPVTALSVT------------ -------------------------------------------------- ---ETxSKKSxAFYPALFxGVTYPCIHAVWARWAPPLERSRMASLAFAGS YVGTVVSLPVCGVLANELGWPSIFYVFGVVGLIWFIIWMYVVKEGPEMDP KISPQELEYLQNILGQTDKS---------------------------VFT LGAEKVLANREV-------------------------------------- ------DLRESTHTSREMGHTxNLVHPWRAFFTSMPVWAVIVAHFCENWG FYTLLTQLPTFMK--------DALEFNLKKAGFMSALPYLVMAIVLSFSG QLADYLITNKYLNTSQxNCERYEALTGGFSAKQWMDRVSGMGSxxxxxxx xxxxxxxxxxx--------------------------------------- -----------------------------------------ARKLFTCSA FMGQ--------AVFMLMTCFLLTPTGAVSCLTAAVGLGAFAWSGFSVNH LDIAPQHASVLMGLSNTVATLPGIISPSITGILVQNK------------- ----TVDEWRVVFYMASFIYLFGALFYGVFSSGEIQPWAEHK-NNQDRTK IDDK >Tps -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------MYFFWRRRRYMVAMLAFFGFFNVYALRVNFS VAIVAMTSNRTVEENGTNVEY----------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------GPEFDWDSKIQGLLLS SFFFGYICTQILGGWLASRVGGNKVYGIGIAATSILTIVMPAVTYFPDHA VIPMIILVRVVEGLFE---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------GVTYPCIHAVWARWAPPLERSRMASLAFAGS YVGTVVSLPVCGLLANELGWPSIFYVFGVVGLIWFIIWMYVVKEGPEMDP KISPQELEYLQNILGQTDK------------------------------- -------------------------------------------------- ----------------------NLVHPWRAFFTSMPVWAVIVAHFCENWG FYTLLTQLPTFMK--------DALEFNLKKAGFMSALPYLVMAIVLSFSG QLADYLITNKYLNTSQ---------------------------------- -------------------------------------------------- -----------------------------------------xRKLFTCSA FMGQ--------AVFMLMTCFLLTPTGAVSCLTAAVGLGAFAWSGFSVNH LDIAPQHASVLMGLSNTMATLPGIISPSITGILVQNK------------- ----TVDEWRVVFYMASFIYLFGALFYGAFSSGEIQPWAEHK-INQDRTK IDEK >Tte -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------MYFFWRRRRYMVAMLAFFGFFNVYALRVNFS VAIVAMTSNRTVKENGTIVEYVx--------------------------- ----------------xNxxQGKQCPxxPWFHRHCANLVIVYKNDLQRSL RNELxQFAAQVLNMKENYKxxxx-------xxx----------------- -------------------------------------------------- ---------------------------------EGPEFDWDSKTQGLLLS SFFFGYICTQILGGWLASRVGGNKVYGIGIAATSILTIVMPAVTYFPDHA VIPMIILVRVVEGLFE---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------GVTYPCIHAVWARWAPPLERSRMASLAFAGS YVGTVVSLPICGILANELGWPSIFYVFGVVGLIWFIIWMYVVKEGPEMDP KISPQELDYLQNILGQTDK------------------------------- -------------------------------------------------- ----------------------NLVHPWRKFFTSMPVWAVIVAHFCENWG FYTLLTQLPTFMK--------DALEFNLKKAGFMSALPYLVMAIVLSFSG QLADYLITNKYLNTSQxNCMRYEALTGGFSVKQRLDR------------- ----------FPPLEKKxx------xxxxxxxxxxxxxxxxxxxF----- ----------------------------------------IVRKLFTCSA FMGQ--------AVFMLMTCFLLTPTGAVSCLTAAVGLGAFAWSGFSVNH LDIAPQHASVLMGLSNTMATLPGIISPSITGILVQNK------------- ----TVDEWRVIFYMASSIYLFGALFYGAFSSGQIQPWAEHK-NNQDRTK IDEK >Tdi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------MYFFWRRRRYMVAMLAFFGFFNVYALRVNFS VAIVAMTSNRTVEENGTNVEYA---------------------------- -------------------------------------------------- --------------------------------xxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxDGPEFDWDSKIQGLLLS SFFFGYICTQILGGWLASRVGGNKVYGIGIAATSILTIVMPAVTYFPDHA VIPMIILVRVVEGLFERCDKNTKASTSxxxxxCSKISPExKGTRLLQTCN SAICDRDE----------------EQGYFGPVPALPVTxxxxxxPVxxxx xFSSAYLIRGPVRKSNSSFRLSETGVSTDPLTSPPPNSxxxxxxxxxxxx xxxx---------------GVTYPCIHAVWARWAPPLERSRMASLAFAGS YVGTVVSLPVCGLLANELGWPSIFYVFGVVGLIWFIIWMYVVKEGPEMDP KISPQELEYLQNILGQTDK------------------------------- -------------------------------------------------- ----------------------NLVHPWRAFFTSMPVWAVIVAHFCENWG FYTLLTQLPTFMKGKLLNLTPDALEFNLKKAGFMSALPYLVMAIVLSFSG QLADYLITNKYLNTS----------------------------------- -------------------------------------------------- -------------------------------------------------- ---xxxxxxxxxAVFMLMTCFLLTPTGAVSCLTAAVGLGAFAWSGFSVNH LDIAPQHASVLMGLSNTMATLPGIISPSITGILVQNK------------- ----TVNEWRVVFYMASFIYLFGALFYGAFSSGEIQPWAEHK-INQDRTK IDEK >Tce -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------------MASLAFAGS YVGTVVSLPVCGVLANELGWPSIFYVFGVVGLIWFIIWMYVVKEGPEMDP KISPQELEYLQNILGQTDK------------------------------- -------------------------------------------------- ----------------------NLVHPWRAFFTSMPVWAVIVAHFCENWG FYTLLTQLPTFMK--------DALEFNLKKAGFMSALPYLVMAIVLSFSG QLADYLITNKYLNTSQxNCERYEALTGGFSAKQWMDRVSGMGSxxxxxxx xxxxxxxxxxx-------xxxxxxxx------------------------ -----------------------------------------xx------- -----------------------------------------------VNH LDIAPQHASVLMGLSNTVATLPGIISPSITGILVQNKxxxxxxxxxxxxx xxxx---------------------------------------------- ---x >Tpa M------------------------xDFT--------------------- ----------------------------YSSATV---------------- -------------------------------------------------- -------------------------------------------------- -------------GDGLGPMYFFWRRRRYMVAMLAFFGFFNVYALRVNFS VAIVAMTSNRTVKENGTIVEYMYFWFGISLSPxxxxxxxxxxxxxxxLAx xxxxxxxxxxxxxxxxxNLxQGKQCPLPPWFHHHCANLVTVYKNDLQRSL RNELxQFAAQVLNMKEIYKDSFxxxxxxxxx------------------- -------------------------------------------------- ----------------------------------GPEFDWDSKTQGLLLS SFFFGYICTQILGGWLASRVGGNKVYGIGIAATSILTIVMPAVTYFPDHA VIPMIILVRVVEGLFE---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------GVTYPCIHAVWARWAPPLERSRMASLAFAGS YVGTVVSLPICGILANELGWPSIFYVFGVVGLIWFIIWMYVVKEGPEMDP KISPQELDYLQNILGQTDK------------------------------- -------------------------------------------------- ----------------------NLVHPWRKFFTSMPVWAVIVAHFCENWG FYTLLTQLPTFMK--------DALEFNLKKAGFMSALPYLVMAIVLSFSG QLADYLITNKYLNTSQxNCMRYEAMTGGFSVKQRLDR------------- ----------FPPLEKKxx------xxxxxxxxxxxxxxxxSxxFxVCDN NFLWQENIFTSLRHQNIRDFDFVxxxxxxxxxxxKIxxxxNVRKLFTCSA FMGQ--------AVFMLMTCFLLTPTGAVSCLTAAVGLGAFAWSGFSVNH LDIAPQHASVLMGLSNTMATLPGIISPSITGILVQN-------------- -------------------------------------------------- ---x >Tbi M------------------------xDFT--------------------- ----------------------------YSSATG---------------- -------------------------------------------------- -------------------------------------------------- -------------GDGLGPMYFFWRRRRYMVAMLAFFGFFNVYALRVNFS VAIVAMTSNRTVKENGTIVEYMYFWFGISLSPxxKIAGRHQRMITSSLAx xxxxxxxxxxxxxxxxx---xxxxxxLPPWFHRHCANLVIxxxxDLQRSL RNELxxxxxxxxxxxxxxxxxxxxxxxxxxx------------------- -------------------------------------------------- ----------------------------------GPEFDWDSKTQGLLLS SFFFGYICTQILGGWLASRVGGNKVYGIGIAATSILTIVMPAVTYFPDHA VIPMIILVRVVEGLFE---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------GVTYPCIHAVWARWAPPLERSRMASLAFAGS YVGTVVSLPICGILANELGWPSIFYVF----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------DALEFNLKKAGFMSALPYLVMAIVLSFSG QLADYLITNKYLNTSQ---------------------------------- -------------------------------------------------- -----------------------------------------xxxxxTCxx xMGQ--------AVFMLMTCFLLTPTGAVSCLTAAVGLGAFAWSGFSVNH LDIAPQHASVLMGLSNTMATLPGIISPSITGILVQNK------------- ----TVDEWRVIFYMASSIYLFGALFYGAFSSGQIQPWAEHKxNNQDRTK IDEK >Tcm x------------------------x------------------------ -------------------------------------------------- -------------------------------------------------- ------------------------------------------------xx xxxxxxxx------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------VLSVVGLIWFIIWIYVVKEGPEMDP KISPQELEYLQNILGQTDK------------------------------- -----------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxx---------------xxxx------------------------ ----------------------ALEFNLKKAGFMSALPYLVMAIVLSFSG QLADYLITNKYLNTSQ---------------------------------- -------------------------------------------------- -----------------------------------------xRKLFTCSA FMGQ--------AVFMLMTCFLLTPTGAVSCLTAAVGLGAFAWSGFSVNH LDIAPQHASVLMGLSNTMATLPGIISPSITGILVQNK------------- ----TVDEWRVVFYMASSIYLFGALFYGAFSSGQIQPWAEHK-INQDRTK IDDK >Tsi MxTLVxxxSSQLTDDSFEKSPDQxxxxxxxPDxLxKHIEDVIERAQGMVT GPxxxxLGGAWRPRDPEREASIRxxxxxxSSATV---------------- -------------------------------------------------- -------------------------------------------------- -------------GDGLGPMYFFWRRRRYMVAMLAFFGFFNVYALRVNFS VAIVAMTSNRTVEENGTNVEY----------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------xxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxHGxxxGGPEFDWDSKTQGLLLS SFFFGYICTQILGGLLASRVGGNKVYGIGIAATSILTIVMPAVTYFPDHA VIPMIILVRVVEGLFERCDKNTK--------------------------- -------ELPFYCTTAPKYLxxxxEQGRSGPATALSVT------------ -------------------------------------------------- ---Exxx-----------xGVTYPCIHAVWARWAPPLERSRMASLAFAGS YVGTVVSLPVCGLLANELGWPSIFYVF----------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------DALEFNLKKAGFMSALPYLVMAIVLSFSG QLADYLITNKYLNTSQ---------------------------------- -------------------------------------------------- -----------------------------------------xRKLFTCSA FMGQ--------AVFMLMTCFLLTPTGAVSCLTAAVGLGAFAWSGFSVNH LDIAPQHASVLMGLSNTMATLPGIISPSITGILVQNK------------- ----TVDEWRVVFYMASSIYLFGALFYGAFSSGQIQPWAEHK-INQDRTK IDDK