>Tge -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------------ESSTEDDGTKITKET IQSIQVTKEEKVSVDGDLIDEKIVA-DLVAATIVESPTKLKVSTAEEEEP SDIEFKLSDTIDKGELSDDERLKVSVPSPIVSPTKDVFKVLESKYDPSAL AAIDIDTSVPDKASVEPLIEKEPSLEVRFEEILMPSATEQVGERTPVETH EESVPEEPVKVSEIPLKEEEVSIVPTEILQQVCAVDKPLDKETIKKEERP QLEDTLTEKVTPPELISVFETEETYVIPKLREVSKVVSEVELIKALEEDI VVEIKDDKTTTSEE---------------------EPDKEESEKREEP-- --LSEKEIPPSDGKIVAKEIARTLELVPVKEETIEPKHVSVDV--RSEFD SKVSSEILK-------------------DDI-------SDSKLMDLGR-- ------VVLSGV------------------------------------VE VIDIAMKDEEA--------------------------------------- --FAEEVVSVV-------------ESTDE--------------------- ---------KILMRE-------LDLHLDTKKRSPSEEATPELIV------ -------------------------------------------------- ---KSETSESSPIxTVFSE---IDVKDEEVRF-----------VEGETLK EEGVSESPEISELDTIEDKVE-----------LPQE-------------- SMKTGVTLEDVSPSVDAIITEEAESLAVAEAPI--SPDKHITIGTKESSE AKLVVHVVKELPDDRVKLDQIKP-----------------------SLFD ESSTEDDGTKITKE--------------TIQSIQ----VTKEEKVSVDGD LIDEKIVA-xxxAATI---------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------x >Tte -------------------------------------------------- ----------------------------------------------ELDT IEDKVELPQESLKTGVTLEDVSPSVDAIITEEAESLAVAEAPISPDKHIT IGTKESSEAKLVVHVVKELPDDRVKLDQIKPSLFDESSTEDDGTKITKET IQSIQVTKEEKVSVDGDLIDEKIVA-DLVAATIVESPTKLKVSTAEEEEP SDIEFKLSDTIDKGELSDDERLKVSVPSPIVSPTKDVFKVLESKYDPSAL AAIDIDTSVPDKASVEPLIEKEPSLEVRFEEILMPPATEQVGERTPVETH EESVPEEPVKVSEIPLKEEEVSIVPTEILQQVCAVDKPLDKETIKKEERP QLEDTLTEKVTPPELISVYETEETYVIPKLREVSKVVSEVELIKALEEDI VVEIKDDKTTTSEE---------------------EPDKEESEKREEP-- --LSEKEIPPSDGKIVAKEIARTLELVPVKEETIEPKHVSVDV--RSEFD SKVSSEILK-------------------DDI-------SDSKLMDLGR-- ------VVLSGV------------------------------------VE VIDIAMKEEEA--------------------------------------- --FAEEVVSVV-------------ESTDE--------------------- ---------KILMRE-------LDLHLDTKKRSPSEEATPELIV------ -------------------------------------------------- ---KSETSESSHIxTVFSE---IDVKDEEVRF-----------VEGETLK EEGVSESPEISELDTIEDKVE-----------LPQE-------------- SLKTGVTLEDVSPSVDAIITEEAESLAVAEAPI--SPDKHITIGTKESSE AKLVVHVVKELPDDRVKLYQIKP-----------------------SLF- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------- >Tbi M---------------------------RELDLHLDTKKRSPSEEATPEL IVKSETSESSHITTVFSEIDVKDEEVRFVEGETLKEEGVSESPEISELDT IEDKVELPQESLKTGVTLEDVSPSVDAIITEEAESLAVAEAPISPDKHIT IGTKESSEAKLVVHVVKELPDDRVKLDQIKPSLFDESSTEDDGTKITKET IQSIQVTKEEKVSVDGDLIDEKIVA-DLVAATIVESPTKLKVSTAEEEEP SDIEFKLSDTIDKGELSDDERLKVSVPSPIVSPTKDVFKVLESKYDPSAL AAIDIDTSVPDKASVEPLIEKEPSLEVRFEEILMPSATEQVGERTPVETH EESVPEEPVKVSEIPLKEEEVSIVPTEILQQVCAVDKPLDKETIKKEERP QLEDTLTEKVTPPELISVFETEETYVIPKLREVSKVVSEVELIKALEEDI VVEIKDDKTTTSEE---------------------EPDKEESEKREEP-- --LSEKEIPPSDGKIVAKEIARTLELVPVKEETIEPKHVSVDV--RSEFD SKVSSEILK-------------------DDI-------SDSKLMDLGR-- ------VVLSGV------------------------------------VE VIDIAMKEEEA--------------------------------------- --FAEEVVSVV-------------ESTDE--------------------- ---------KILMRE-------LDLHLDTKKRSPSEEATPELIV------ -------------------------------------------------- ---KSETSESx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------- >Tps IDIAMKDVEALVEEVVSVVESTDEKILTREVGLILDTKKISPDEIVTHEL IVESETS------TVFSKLDVKDDEVKLFDGETLKDEGVSVSREISDFDT IEDKEELPQESMKTGVTLEQVSPSVVAIISEEAESLSVVEAQISPDKDII IDTKESSEAKFLVHDVEELPDVIVQEDQIKPSVFEESSTEEDRTKVTKES IQSIHVMEEEKLGVDGELIDEKIVAEDFVAAKIVESPTKTKVSTATEEKP SDIEFKVSDTAYEGDLIDVEKIKGSVPSPITSPTKDIFKISEAKHDPPIL GAIVIDSSAADKASFEPSVEKEPSLEVRFEEILMTPTTEQVGESIIVESH EEGVSKEFLKVSKVPLTEEEVSIVPPEILQPVGAVDKLSDQEIIKKEDRA QIEDTLPERITPPELTPVLETEDTYAIPTLIE---VVSEVELIKALEEDI VVELKDYKTTTSEE---------------------EPTKEESEKHEQQ-- --LSEKEVPPSDGKLVVKDIAKTLELIPVKEDTIEPKHVSVDV--RSEFD SKFAVEILK-------------------EDI-------SDSKLMDVGR-- ------VVLSDF------------------------------------VE AIDIAMKDEEA--------------------------------------- --LVEEVVSVV-------------ESTDE--------------------- ---------KILTRE-------VGLILDTKKISPDEIVTHELIV------ -------------------------------------------------- ---ESETS------TVFSK---LDVKDDEVKL-----------FDGETLK DEGVSVSREISDFDTIEDK------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------x >Tms -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------SPTKDIFKILEAKHDPPIL GAIVIDS--ADKASVEPLLEKEPSPEVRFEEILMTPATEQVGESIIVESH EEGVSKEILEVSTVPLKEEEVSIVPPEKLQPVGAVDKLSDQEIIKKDDMV QLEDTLTERITPPELISVFETEDTDVIPKLME---VVSEVELIKALEEDI VVELKDDKTTTSEE---------------------EPTKEESEKHEQP-- --LSEKEVPPSDGKLVVKEIAKTLELIPVKEDTIEPKHVSVDV--RSEFD SKVSVEILK-------------------EDI-------SDSKLMDVGR-- ------VVLSDF------------------------------------VE VIDIAMKDEGA--------------------------------------- --LVEEVVSVV-------------ESTDE--------------------- ---------KILTRD-------VDLILDTKKISPDEKVPQELIV------ -------------------------------------------------- ---ESETS------TVFSK---LDVKDDEVKF-----------VDGETLK DEGVSESPEISELDTIEDKEE-----------LPQE-------------- SMKTGVTLEQVSPSVDAIISEEAESLSVVEAQI--SPDKDIIIDTKESSE AKFLVHDVKELPDVIVKLDQIKP-----------------------SVFE ESSTEEDGTKVTKE--------------TIQTIH----VMKEEKVGVDGG LIDEKFVAEDLVAAKIVESPTKT------KVSTAMEEKPSDIEFKVSDTI YEGDLIDVEKIKVSVPSPITSPTKDIFK---------------------- -------------------------------------------------- ---ILEAKHDPPILGAIVIDS--ADKA----------------------- ----SVEP------------------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------- >Tsi -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -AIVIDSSVADKASFEPSVEKDPSLEVRFEEILMTPTTEQVGESIIVESH EEGVSKEILKVSKVPLTEEEVSIVPPEILQPVGAVDKLSDQEIIKKEDRA QIEDTLPERITPPELIAVLETEDTYAIPTLIE---VVSEVELIKALEEDI VVELKDYKTTTSEE---------------------EPTKEESEKHEQQ-- --LSEKEVTPSDGKIVVKDIAKSLELIPVKEDTIEPKHVSVDV--RSEFD SKFAVEILK-------------------EDI-------SDSKLMDVGR-- ------VVLSDF------------------------------------VE AIDIAMKDEEA--------------------------------------- --LVEEVVSVV-------------ESTDE--------------------- ---------KILTRE-------VGLILDTKKISPDEIVTHELIV------ -------------------------------------------------- ---ESETS------TVFSK---LDVKDDEVKL-----------FDEETLK DEGVSVSREISDFDTVEDKEE-----------LPQE-------------- SMKTGVSLEQVSPSVVAIISEEAESLSVVEAQI--SPDKDIIIDTKESSE AKFLVHDVEELPDVIVKEDQIKP-----------------------SVFE ESSTEEDGTKVTKE--------------SIQSIH----VMEEEKLGVDGE LVDEKFVPEDFVAAKIVESPTKR------KVSTATEEKPSDIEFKVSDTA YEGDLIDVEKKKVSVPSPITSPTKDILK---------------------- -------------------------------------------------- ---ISEAKHDPPILGAIVIDSxVxDKA----------------------- ----SFEP--------SVEKDPSLEVRFEEILMTP--------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------T >Tcm -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------KVSTATEEKP SDIEFKVSDTAYEGDLIDVEKIKVSVPSPITSPTKDILKISEAKHDPPIL GAIVIDSSVADKASFEPSVEKDPSLEVRFEEILMTPTTEQVGESIIVESH EEGVSKEILKVSKVPLTEEEVSIVPPEILQPVGAVDKLSDQEIIKKEDRA QIEDTLPERITPPELIAVLETEDTYAIPTLIE---VVSEVELIKALEEDI VVELKDYKTTTSEE---------------------EPTKEESEKHEQQ-- --LSEKEVTPSDGKIVVKDIAKSLELIPVKEDTIEPKHVSVDV--RSEFD SKFAVEILK-------------------EDI-------SDSKLMDVGR-- ------VVLSDF------------------------------------VE AIDIAMKDEEA--------------------------------------- --LVEEVVSVV-------------ESTDE--------------------- ---------KILTRE-------VGLILDTKKISPDEIVTHELIV------ -------------------------------------------------- ---ESETS------TVFSK---LDVKDDEVKL-----------FDEETLK DEGVSVSREISDFDTVEDKEE-----------LPQE-------------- SMKTGVSLEQVSPSVVAIISEEAESLSVVEAQI--SPDKDIIIDTKESSE AKFLVHDVEELPDVIVKEDQIKP-----------------------SVFE ESSTEEDGTKVTKE--------------SIQSIH----VMEEEKLGVDGE LVDEKFVPEDFVAAKIVESPTKT------KVSTATEEKPSDIEFKVSDTA YEGDLI-------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------- >Tdi x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------EELPDVIVQEDQIKPSVFEDSSTEEDRTKVTKES IQSIHVMEEEKLGVDGELIDEKIVAEDFVAAKIVESPTKTKVSTATEEKP SDIEFKVSDTAYEGDLIDVEKIKGSVPSPITSPTKDIFKISEAKHDPPIL GAIVIDSSAADKASFEPSVEKEPSLEVRFEEILMTPTTEQVGESIIVESH EEGVSKEFLKVSKVPLTEEEVSIVPPEILQPVGAVDKLSDQEIIKKEDRA QIEDTLPERITPPELTPVLETEDTYAIPTLIE---VVSEVELIKALEEDI VVELKDYKTTTSEE---------------------EPTKEESEKHEQQ-- --LSEKEVPPSDGKLVVKDIAKTLELIPVKEDTIEPKHVSVDV--RSEFD SKFAVEISK-------------------EDI-------SDSKLMDVGR-- ------VVLSDF------------------------------------VE AIDIAMKDEEA--------------------------------------- --LVEEVVSVV-------------ESTDE--------------------- ---------KILTRE-------VGLILDTKKISPDEIVTHELIV------ -------------------------------------------------- ---ESETS------TVFSK---LDVKDDEVKL-----------FDGETLK DEGVSVSREISDFDTIEDKEE-----------LPQE-------------- SMKTGVTLEQVSPSVVAIISEEAESLSVVEAQI--SPDKDIIIDTKESSE AKFLVHDVEELPDVIVQEDQIKP-----------------------SVFE DSSTEEDRTKVTKE--------------SIQSIH----VMEEEKLGVDGE LIDEKIVAEDFVAAKIVESPTKT------KVSTATEEKPSDIEFKVSDTA YEGDLID------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------- >Tce -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------VIPKLME---VVSEVELIKALEEDI VVELKDDKTTTSEE---------------------EPTKEESEKHEQP-- --LSEKEVPPSDGKLVVKEIAKTLELIPVKEDTIEPKHVSVDV--RSEFD SKVSVEILK-------------------EDI-------SDSKLMDVGR-- ------VVLSDF------------------------------------VE VIDIAMKDEGA--------------------------------------- --LVEEVVSVV-------------ESTDE--------------------- ---------KILTRD-------VDLILDTKKISPDEKVPQELIV------ -------------------------------------------------- ---ESETS------TVFSK---LDVKDDEVKF-----------VDGETLK DEGVSESPEISELDTIEDKEE-----------LPQE-------------- SMKTGVTLEQVSPSVDAIISEEAESLSVVEAQI--SPDKDIIIDTKESSE AKFLVHDVKELPDVIVKLDQIKP-----------------------SVFE ESSTEEDGTKVTKE--------------TIQTIH----VMKEEKVGVDGG LIDEKFVAEDLVAAKIVESPTKT------KVSTAMEEKPSDIEFKVSDTI YEGDLIDVEKIKVSVPSPITSPTKDIFK---------------------- -------------------------------------------------- ---ILEAKHEPPILGAIVIDS--ADKA----------------------- ----SVEP--------LLEKEPSPEVRFEEILMTPAx------------- ----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxKxxPxxx xxxxxxQExxxxDDMVQLE------------------------------- -----------xxxxx---------------------------------- -----------------------RIxx------xxxxxx----------- -------------------------------------------------- ---------xxxExxxxxx------------------------------- --xLMEVVSEVELI-----------------KALEEDIxxxxxx------ --------------------------DxxxxxxEEPTKEExxxxxxx--- -------------------------------------------------- ------------xxxxxxxxS-----------------DGKLV-----VK EITKx--------------------------------------------- ----------Lxx--------------xx >Tpa -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------------------------------xxxx------ ---------------LREEEVSIVPPEIYQPVGAVDKLLNKGIIKKENTA QFEDTLSVKVT-PELISILKPEQSDIIPEFLEVSKVIPEDEVVTALEKNI VGMPKYYKSDIEKExxxxxxxxxxxxxxxxxxFSITPLHYExxxxxxxxx VxxxEVKEATRQIKEEIKELKPDLTxxxxxxxxxxxxxxTIxxxxSSELD DIKSLQIVGxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxFCEDxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxNNxxxxxxxxxxxxxxxxxxYDINLGTRKIDDRASxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxx-xxxxxxxxxxxxxxxxxxxxxxxKKVMxxKLQSKxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxQKxxxxxxxxxKIxxxxxxxxxxxxxxxxx xxxLNGYVSKPEDVGISVERGxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxHPxxxxxxxxxxxxxxTVKQKYPNINTIHAPYYxxxxxxxxxxxS PLDPEICLPTPVANIPSPxxxxxxxxxxxxxxxxxxxxxxxxxxxxS--- ---------------PSPSASPVKSVARxxxxxxxxxxxxxxxxxxxxxx xVRGQQQSGVTQLLTSEVFTRTxxxxxxxxxxxxxxxxxxxxRRVAVASG TRSVLESVFVPxxxxxxxxxx--xxxxxxxxxxxxxxxxxxxxxxxxxxR VRGTSASPKHxxxxxxxxxxxxxSKxxxxxxxxxxxxxxxxxxxxSIxxx xxxxxxxSDSVAVxxxxxxxSPTKPSKQPSPLKSSQVS---EERLSPIxx xxAVTPPRVxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx AASVQSMxxxxxxxxxxxxxNMGIDSHWDxxxxxxxxxxxxxxxxxDLxx xxxxxxxxxxxxxxxxxFLTSSLRKTPRTVLPxxxxxxxxxxxxxxxFQH NVVRFSAAIDPxxxxxxxxxxxxxxGEDDIHTLSPSGSELDYAxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxYHHxxxxxxxxxxxxxxxxxxx xxxxKITPVLNSLVITxGELxxLTDTEYIHTSDEDDNYESSMxPKTPIPL DNLLDFQSTLEECVIINSPNKNDNILKSEISRSAQGPASANTFLGFSLPD TKEGLTDLEDFGLSGEDEPPDISEEIFEENDFLTGLICDGENVDIADRIK TIVQTSPSPPSTPERRQVKDKNVRIRRRKVSPKKSHAIENKYSQYLSPSP SSVLFSDNTDVESLPSDSEDEEKRDKRKT