>Tge x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------------------xGRYILREENSRTILRLPSDN SExxKGPQYLAAxx------------------------------------ -------------------------------------------------- -------------------------------------------------- -----------AxxxA---------------------FVAGTFMSWTSPA LPLLQANNSVPYITSEE--------------------------------- GSWIGSLLNLGAFIGAIPAGILADHIGRRTTLCGLAVPFFISWLMIAFCS SALELYVGRIVGGMAVGAVSVVAPMYISELADSKVRGALGTFFQLQITVG ILFGYLVGMVGDHRVLAFILSVLPVVYFVSFIWMPESPVYLLSKDKLNEA KRSLQWFRGSKYDIEDEMVRMVESSGDSQKRKGGLGELLSNPVTRKAFTI ALGLMTFQQLSGINAVIFYTGQIFDLAGSSIPSTTACIIIGVVQVIATYV STLLVDRAGRRILLLISDSVMALCLGVLGAYFHLLNNNYDTSDVSWVPIV SVATFIVVFSLGFGPIPWIMLGELFPANVKGIASAVAAAFSWILSFAVTK AFQNMTSSLGEDITFWVFTGICVIGTIFVFVMVPETKGKDLNKIQEELSG KPSNVELKMVESDDGLKTEKIIFHLPD >Tbi xxxxxxxxxxx--------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------------FMSWTSPA LPLLQANNSVPYITSEE--------------------------------- GSWIGSLLNLGAFIGAIPAGILADHIGRRTTLCGLAVPFFVSWLMIAFCS SALELYVGRIMGGMAVGAVSVVAPMYISELADSKVRGALGTFFQLQITLG ILCGYLVGMVGDHRVLAFILSVLPVVYFVSFIWMPESPVYLLSKDKLNEA KRSLQWFRGSNYDIEDEMVRMTESSGDSQKRKGGLGELLSNPVTRKALTI ALGLMTFQQLSGINAVIFYTGQIFDLAGSSIPSTTACIIIGVVQVIATYV STLLVDRAGRRILLLISDSVMALCLGVLGAYFHLLNNNYDTSDVSWVPIV SVATFIVVFSLGFGPIPWIMLGELFPANVKGIASAVAAAFSWILSFAVTK AFQNMTRSLGEDITFWVFTGICVIGTIFVFVMVPETKGKDLNEIQEELSG KPNNVELKMVESDDGIKTEKIIFRLPD >Tte x---------xxxxxxxxxxxxxxxxxxxxxx------------------ --------------------------------------------xxxxxx xxxxxxx------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------------------KMSGRYILREENSRTILRLPSDN SExx---------------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------xxxA---------------------FVAGTFMSWTSPA LPLLQANNSVPYITSEE--------------------------------- GSWIGSLLNLGAFIGAIPAGILADHIGRRTTLCGLAVPFFVSWLMIAFCS SALELYVGRIMGGMAVGAVSVVAPMYISELADSKVRGALGTFFQLQITLG ILCGYLVGMVGDHRVLAFILSVLPVVYFVSFIWMPESPVYLLSKDKLNEA KRSLQWFRGSNYDIEDEMVRMTESSGDSQKRKGGLGELLSNPVTRKALTI ALGLMTFQQLSGINAVIFYTGQIFDLAGSSIPSTTACIIIGVVQVIATYV STLLVDRAGRRILLLISDSVMALCLGVLGAYFHLLNNNYDTSDVSWVPIV SVATFIVVFSLGFGPIPWIMLGELFPANVKGIASAVAAAFSWILSFAVTK AFQNMTRSLGEDITFWVFTGICVIGTIFVFVMVPETKGKDLNEIQEELSG KPNNVELKMVESDDGIKTENIIFRLPD >Tpa x------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---------------xxxxxxxxxxxxxxxxxxxxxxFVAGTFMSWTSPA LPLLQANNSVPYITSEE--------------------------------- GSWIGSLLNLGAFIGAIPAGILADHIGRRTTLCGLAVPFFVSWLMIAFCS SALELYVGRIVGGMAVGAVSVVAPMYISELADSKVRGALGTFFQLQITVG ILFGYLVGMVGDHRVLAFILSVLPVVYFVSFIWMPESPVYLLSKDKLNEA KRSLQWFRGSKYDIEDEMVRMVESSGDSQKRKGGLGELLSNPVTRKAFTI ALGLMTFQQLSGINAVIFYTGQIFDLAGSSIPSTTACIIIGVVQVIATYV STLLVDRAGRRILLLISDSVMALCLGVLGAYFHLLNNNYDTSDVSWVPIV SVATFIVVFSLGFGPIPWIMLGELFPANVKGIASAVAAAFSWILSFAVTK AFQNMTSSLGEDITFWVFTGICVIGTIFVFFMVPETKGKDLNEIQEDLSG KPSNVELKMVESDDGLKTEKIIFHLPD >Tms x------------------------------xxx---------------- --------------------------xxxxxxxxxxxxxxxxxxxxx--- ------xxxxxxxxxxxxxx------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--- ----------xxxxxA---------------------FIAGTFMSWTSPA LPLLQANSSVPYITSEE--------------------------------- GSWIGSLLNLGAFIGAIPAGILADHIGRRTTLCGLAVPFFVSWLIIAFCS SALELYVGRIVGGMAVGAVSVVAPMYISELADSKVRGALGTFFQLQITLG ILCGYLVGMVGDHRILAFILSVLPVVYFVSFIWMPESPVYLLSKDKPNEA KRSLQWFRGSNYDIEDEMVRMTESSGDSQKRKGGLGELLSNPVMRKAFTI ALGLMTFQQLSGVNAVIFYTGQIFDLAGSSIPSITACIIIGVVQVIATYV STLLVDRAGRRILLLISDSVMALCLGVLGAYFHLLNNNYDTSDVSWVPIV SVAIFIVVFSLGFGPIPWIMLGELFPANVKGVASAVAAAFSWILSFAVTK AFQNMTSSLGEDITFWIFTGICVIGTIFVFVMVPETKGKDLNEIQEELSG KHSNVELKVVEYDEGIKAEKIIFHLPD >Tce x------------------------------x------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------PxxxA---------------------FIAGTFMSWTSPA LPLLQANSSVPYITSEE--------------------------------- GSWIGSLLNLGAFIGAIPAGILADHIGRRTTLCGLAVPFFVSWLIIAFCS SALELYVGRIVGGMAVGAVSVVAPMYISELADSKVRGALGTFFQLQITLG ILCGYLVGMVGDHRVLAFILSVLPVVYFVSFIWMPESPVYLLSKDKPNEA KRSLQWFRGSNYDIEDEMVRMTESSGDSQKRKGGLGELLSNPVMRKAFTI ALGLMTFQQLSGVNAVIFYTGQIFDLAGSSIPSITACIIIGVVQVIATYV STLLVDRAGRRILLLISDSVMALCLGVLGAYFHLLNNNYDTSDVSWVPIV SVAIFIVVFSLGFGPIPWIMLGELFPANVKGVASAVAAAFSWILSFAVTK AFQNMTSSLGEDITFWIFTGICVIGTIFVFVMVPETKGKDLNEIQEELSG KHSNVELKVVEYDEGIKAEKIIFHLPD >Tsi x------------------------------x------------------ -------------------------------------------------- -------------------xDSGETDIPASSGEQSWIGSLTPLGAVFSPF LAGYAADRWGRK-------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- xxxxxxxxxxxxxxxxxxxxxxxxx------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ---KVRGALGSLLQIMISFGLLSQYVVGPYVSYLVLTIFSVMVPFLFVAA MWFIPESPYQxIMVRKNQQALESLQWLRGTKSEAVKEELAVIExYARLGS ATAADRSAGILHHHNKSPSLRLSQENVRDMLANKATPRDLIATKATVTAL YLSMGLVSLQxxxxxNAILFYCQTIFESSGSGLDSSVATIIVGTVMLLAS TCTPFVVDSLGRRILLLFSAGGMAVSLAALGTFFHLQNNGSDTSSIGWLP VVSLVVYILVYSVGFGSLPWAVMGELFTPNVKSMASSVSASICWFFAFLI TKFFSTLSQELGSDYAIWIFGIFAVVAFVVGVLPPARDQGEVPARDTGHP RRIDAQCGWHVLDNVICCLVPNAIGDYKMSGRYILREENSRTILRLPSDN SExxKGPQYLAAxxDGVGGCHQLAEGLSARAAPDECGRAPEPLGYKLIIV YIQGVRNTWNLFQRNVELFNFIADEGLNQDPPRWRSWLNALVVLSSTAED GDIERQLSPSGVLSHxx--------------------------------- -----------AxxxA---------------------FVAGTFMSWTSPA LPLLQANSSVPYITSEE--------------------------------- GSWIGSLLNLGAFIGAIPAGILADHIGRRTTLCGLAVPFFVSWLMIAFCS SALELYVGRILGGMAVGAVSVVAPMYISELADSKVRGALGTFFQLQITLG ILCGYLVGMVGDHRVLAFILSVLPVVYFVSFIWMPESPVYLLSKDKQNEA RRSLQWFRGSNYDIEDEMVRMTESSGDSQKRKGGLGELLSNPVTRRALTI ALGLMMFQQLSGVNAVIFYTGQIFDLAGSSIPSVTACIIIGVVQVIATYV STLLVDRAGRRILLLISDSVMALCLGVLGAYFHLLNNHYDTSDVSWVPIV SVAIFIVVFSLGFGPIPWIMLGELFPANVKGVASAVAAAFSWILSFAVTK VFQNMTSSLGEDITFWVFTGICVVGTVFVFVMVPETKGKDLNEIQEELSG KHNNVELKVVESDVGVKTEKIIFHLPD >Tcm x------------------------------xxEMVKSVENQVEQNKVLP QYLAGLT------VGCALSWTSPTLLK----------------------- -------------------MDSGETDIPASSGEQSWIGSLTPLGAVFSPF LAGYAADRWGRKTTLIATACPVIVGWVLIACAEPARSIPLIYVGRIIHGL CVGVAFTVLPMYCGEIAEDK------------------------------ -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----VRGALGSLLQIMISFGLLSQYVVGPYVSYLVLTIFSVMVPFLFVAA MWFIPESPYQLIMVRKNQQALESLQWLRGTKSEAVKKELAVIETYARLGS ATAADRSAGILHHHNKSPSLRLSQENVRDMLANKATPRDLIATKATVTAL YLSMGLVSLQxxxxxNAILFYCQTIFESSGSGLDSSVATIIVGTVMLLAS TCTPFVVDSLGRRILLLFSAGGMAVSLAALGTFFHLQNNGSDTSSIGWLP VVSLVVYILVYSVGFGSLPWAVMGELFTPNVKSMASSVSASICWFFAFLI TKFFSTLSQELGSDYAIWIFGIFAVVAFVSCVLPPARDQGEVPxxxTGHP RxIDAQCxWHVLDNVICCLVPNAIGDxKMSGRYILREENSRxxxxxxSDN SExxKGPQYLAAxx------------------------------------ -------------------------------------------------- ----------------------------------------------ETIL NKTEGIVIVxxAxxxA---------------------FVAGTFMSWTSPA LPLLQANSSVPYITSEE--------------------------------- GSWIGSLLNLGAFIGAIPAGILADHIGRRTTLCGLAVPFFVSWLMIAFCS SALELYVGRILGGMAVGAVSVVAPMYISELADSKVRGALGTFFQLQITLG ILCGYLVGMVGDHRVLAFILSVLPVVYFVSFIWMPESPVYLLSKDKQNEA RRSLQWFRGSNYDIEDEMVRMTESSGDSQKRKGGLGELLSNPVTRRALTI ALGLMMFQQLSGVNAVIFYTGQIFDLAGSSIPSVTACIIIGVVQVIATYV STLLVDRAGRRILLLISDSVMALCLGVLGAYFHLLNNHYDTSDVSWVPIV SVAIFIVVFSLGFGPIPWIMLGELFPANVKGVASAVAAAFSWILSFAVTK VFQNMTSSLGEDITFWVFTGICVVGTVFVFVMVPETKGKDLNEIQEELSG KHNNVELKVVESDVGVKTEKIIFHLPD >Tps -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -----------------MVRMTESSGDSQKRKGGLGELLSNPVTRKAFTI ALGLMMFQQLSGVNAVIFYTGQIFDLAGSSIPSVTACIIIGVVQ------ -----------------NSVMALCLGVLGAYFHLLNNHYDTSDVSWVPIV SVAIFIVVFSLGFGPIPWIMLGELFPANVKGVASAVAAAFSWILSFAVTK VFQNMTSSLGEDITFWVFTGICVVGTVFVFVMVPETKGKDLNEIQEELSG KHSNVELKVVESVVGIKTEKIIFHLPD >Tdi x------------------------------------------------- ------xxLLIASVGCAMSWTSPTLxx----------------------- -------------------MDSGETDIPASSSEKSWIGSLTPLGAVFSPF LAGYAADRWGRKxxxxxxxxxxxxxWVLIACAEPARSIPLIYVGRIIxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxxMENKSTPRDLISTKASVTALYLSMGLLALQILTGIDAILF Y---------------------CQDIFAASGGALDSSVATIIVGMLREKN SALDICRRHGSFFGFGPVPWAVTGELFAPNVKSMASSIATSFCWFLAFxx xNFFPTISQELGSDYAFWIFGIFAVVAFVSVFFLLPETKGKSLQEITGHP Rxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx xxxxxxxxxWVLIACAEPARSIPLIYVGRIIxxxxxxxxxxxxxxxxxxx xxxRVRGALGSLLQIMISVGLLSQYVVGPYVSYLVLTIFSVVVPFLFVAA MWFIPESPYQxIMARKNQQALESLQWLRGTKSEAVKEELAVIE------- --------------------------------------------ATATAL YLSVGLVSLQxxxxxNAILFYCQTIFESSGSGLDSSVATIIVGTVMLLAS TCTPFVVDSLGRRILLLFSAGGMAVSLAALGTFFHLQNNGSDTSSIGWLP VVSLVVYILVYSVGFGSLPWAVMGELFTPNVKSMAASVSASICWFFAFLI TKFFSTLSQELGSDYAIWIxxxxxxxxxx--------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- -------------------------------------------------- ----------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx GSWIGSLLNLGAFIGAIPAGILADHIGRRTTLCGLAVPFFVSWLMIAFCS SALELYVGRIVGGMAVGAVSVVAPMYISELADSKVRGALGTFFQLQITLG ILCGYLVGMVGDHRVLAFILSVLPVVYFVSFIWMPESPVYLLSKDKLNEA RR-------SNYDIEDEMVRMTESSGDSQKRKGGLGELLSNPVTRRALTI ALGLMMFQQLSGVNAVIFYTGQIFDLAGSSIPSATACIIIGVVQVIATYV STLLVDRAGRRILLLISDSVMALCLGVLGAYFHLLNNHYDTSDVSWVPIV SVAIFIVVFSLGFGPIPWIMLGELFPANVKGVASAVAAAFSWILSFAVTK VFQNMTSSLGEDITFWVFTGICVVGTVFVFVMVPETKGKDLNEIQEELSG KHSNVELKVVESVVGIKTEKIIFHLPD